International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(24), P. 13398 - 13398
Published: Dec. 13, 2024
The
Na,
K–ATPase
generates
an
asymmetric
ion
gradient
that
supports
multiple
cellular
functions,
including
the
control
of
volume,
neuronal
excitability,
secondary
ionic
transport,
and
movement
molecules
like
amino
acids
glucose.
intracellular
extracellular
levels
Na+
K+
ions
are
classical
local
regulators
enzyme’s
activity.
Additionally,
regulation
is
a
complex
process
occurs
at
levels,
encompassing
its
total
content,
subcellular
distribution,
intrinsic
In
this
context,
enzyme
serves
as
regulatory
target
for
hormones,
either
through
direct
actions
or
via
signaling
cascades
triggered
by
hormone
receptors.
Notably,
FXYDs
small
transmembrane
proteins
serve
intermediaries
linking
hormonal
to
enzymatic
various
levels.
Specifically,
members
FXYD
family,
particularly
FXYD1
FXYD2,
undergo
phosphorylation
kinases
activated
receptor
signaling,
which
subsequently
influences
their
modulation
This
review
describes
effects
cardiotonic
steroid
hormones
such
angiotensin
II,
dopamine,
insulin,
catecholamines
on
K–ATPase.
Furthermore,
highlights
implications
in
diseases
hypertension,
renal
hypomagnesemia,
cancer.
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(22), P. 11873 - 11873
Published: Nov. 5, 2024
Alzheimer's
disease
(AD)
is
a
kind
of
neurodegenerative
diseases
characterized
by
beta-amyloid
deposition
and
neurofibrillary
tangles
also
the
main
cause
dementia.
According
to
statistics,
incidence
AD
constantly
increasing,
bringing
great
burden
individuals
society.
Nonetheless,
there
no
cure
for
AD,
available
drugs
are
very
limited
apart
from
cholinesterase
inhibitors
N-Methyl-D-aspartic
acid
(NMDA)
antagonists,
which
merely
alleviate
symptoms
without
delaying
progression
disease.
Therefore,
an
urgent
need
develop
medicine
that
can
delay
or
it.
In
recent
years,
increasing
evidence
suggests
metal
complexes
have
enormous
potential
treat
through
inhibiting
aggregation
cytotoxicity
Aβ,
interfering
with
congregation
hyperphosphorylation
tau,
regulating
dysfunctional
synaptic
unbalanced
neurotransmitters,
etc.
this
review,
we
summarize
current
their
mechanisms
action
treating
including
ruthenium,
platinum,
zinc,
vanadium,
copper,
magnesium,
other
complexes.
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(22), P. 12441 - 12441
Published: Nov. 19, 2024
Cancer
ranks
among
the
primary
contributors
to
global
mortality.
In
2022,
incidence
of
new
cancer
cases
reached
about
20
million,
while
number
cancer-related
fatalities
9.7
million.
Saudi
Arabia,
there
were
13,399
deaths
caused
by
and
28,113
newly
diagnosed
cancer.
Drug
repurposing
is
a
drug
discovery
strategy
that
has
gained
special
attention
implementation
enhance
process
development
due
its
time-
money-saving
effect.
It
involves
repositioning
existing
medications
clinical
applications.
treatment
therapeutic
area
where
shown
most
prominent
impact.
This
review
presents
compilation
have
been
repurposed
for
various
types
cancers.
describes
initial
pharmacological
classes
drugs
their
applications
mechanisms
action
in
treatment.
The
reports
on
from
successfully
treatment,
including
approved
ones
those
trials
preclinical
development.
stratifies
based
anticancer
repurpose
as
multi-type,
type-specific,
mechanism-directed,
according
classes.
also
reflects
future
potential
novel
therapies.
Future Pharmacology,
Journal Year:
2024,
Volume and Issue:
4(4), P. 743 - 774
Published: Oct. 24, 2024
Metallodrugs
represent
a
critical
area
of
medicinal
chemistry
with
the
potential
to
address
wide
range
diseases.
Their
design
requires
multidisciplinary
approach,
combining
principles
inorganic
chemistry,
pharmacology,
and
molecular
biology
create
effective
safe
therapeutic
agents.
Vanadium,
element
fifth
group
first
transition
series
(3d
metals),
has
been
already
detected
as
crucial
species
in
biological
action
some
enzymes,
e.g.,
nitrogenases
chloroperoxidase;
furthermore,
vanadium-based
compounds
have
recently
described
physiologically
stable
behavior,
having
anticancer,
antidiabetic
(insulin-mimicking),
antiprotozoal,
antibacterial,
antiviral,
inhibition
neurodegenerative
disease
properties.
Since
binding
metallodrugs
serum
albumin
influences
distribution,
stability,
toxicity
(intended
off-target
interactions),
overall
pharmacological
properties,
biophysical
characterization
between
is
one
hot
topics
pharmacology.
Overall,
since
vanadium
complexes
offer
new
possibilities
for
novel
metallodrugs,
this
review
summarized
up-to-date
aspects,
highlighting
proteins
main
targets
based
on
metal.
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(24), P. 13398 - 13398
Published: Dec. 13, 2024
The
Na,
K–ATPase
generates
an
asymmetric
ion
gradient
that
supports
multiple
cellular
functions,
including
the
control
of
volume,
neuronal
excitability,
secondary
ionic
transport,
and
movement
molecules
like
amino
acids
glucose.
intracellular
extracellular
levels
Na+
K+
ions
are
classical
local
regulators
enzyme’s
activity.
Additionally,
regulation
is
a
complex
process
occurs
at
levels,
encompassing
its
total
content,
subcellular
distribution,
intrinsic
In
this
context,
enzyme
serves
as
regulatory
target
for
hormones,
either
through
direct
actions
or
via
signaling
cascades
triggered
by
hormone
receptors.
Notably,
FXYDs
small
transmembrane
proteins
serve
intermediaries
linking
hormonal
to
enzymatic
various
levels.
Specifically,
members
FXYD
family,
particularly
FXYD1
FXYD2,
undergo
phosphorylation
kinases
activated
receptor
signaling,
which
subsequently
influences
their
modulation
This
review
describes
effects
cardiotonic
steroid
hormones
such
angiotensin
II,
dopamine,
insulin,
catecholamines
on
K–ATPase.
Furthermore,
highlights
implications
in
diseases
hypertension,
renal
hypomagnesemia,
cancer.
