Bioactive Hydrogel Formulation Based on Ferulic Acid-Grafted Nano-Chitosan and Bacterial Nanocellulose Enriched with Selenium Nanoparticles from Kombucha Fermentation DOI Creative Commons
Naomi Tritean,

Luminița Dimitriu,

Ştefan‐Ovidiu Dima

et al.

Journal of Functional Biomaterials, Journal Year: 2024, Volume and Issue: 15(7), P. 202 - 202

Published: July 22, 2024

Selenium nanoparticles (SeNPs) have specific properties that result from their biosynthesis particularities. Chitosan can prevent pathogenic biofilm development. A wide palette of bacterial nanocellulose (BNC) biological and physical-chemical are known. The aim this study was to develop a hydrogel formulation (SeBNCSFa) based on ferulic acid-grafted chitosan enriched with SeNPs Kombucha fermentation (SeNPsK), which could be used as an adjuvant for oral implant integration other applications. grafted SeBNCSFa were characterized by biochemical methods. cell viability proliferation HGF-1 gingival fibroblasts investigated, well in vitro antioxidant activity. inflammatory response determined enzyme-linked immunosorbent assay (ELISA) the proinflammatory mediators (IL-6, TNF-α, IL-1β) culture medium. Likewise, amount nitric oxide released measured Griess reaction. antimicrobial activity also investigated. grafting degree acid approximately 1.780 ± 0.07% total monomeric units, assuming single-site per monomer. Fourier-transform infrared spectroscopy evidenced convolution BNC spectra, X-ray diffraction analysis highlighted amorphous rearrangement patterns, suggesting multiple interactions. showed high cytocompatibility, enhanced antioxidant, anti-inflammatory, potentials.

Language: Английский

Unveiling Green Synthesis and Biomedical Theranostic paradigms of Selenium Nanoparticles (SeNPs) - A state-of-the-art comprehensive update DOI Creative Commons
Sagnik Nag,

Shinjini Kar,

Shatakshi Mishra

et al.

International Journal of Pharmaceutics, Journal Year: 2024, Volume and Issue: 662, P. 124535 - 124535

Published: Aug. 1, 2024

The advancements in nanotechnology, pharmaceutical sciences, and healthcare are propelling the field of theranostics, which combines therapy diagnostics, to new heights; emphasizing emergence selenium nanoparticles (SeNPs) as versatile theranostic agents. This comprehensive update offers a holistic perspective on recent developments synthesis applications SeNPs, underscoring their growing importance nanotechnology healthcare. SeNPs have shown significant potential multiple domains, including antioxidant, anti-inflammatory, anticancer, antimicrobial, antidiabetic, wound healing, cytoprotective therapies. review highlights adaptability biocompatibility crucial for advanced disease detection, monitoring, personalized treatment. Special emphasis is placed green techniques, eco-friendly cost-effective benefits biosensing, imaging therapeutic applications. Additionally, appraisal scrutinizes progressive trends smart stimuli-responsive conferring role innovative solutions management diagnostics. Despite promising prophylactic potential, also present several challenges, particularly regarding toxicity concerns. These challenges implications clinical translation thoroughly explored, providing balanced view current state prospects

Language: Английский

Citations

15
Phytochemical profile, anti-inflammatory analysis and cytotoxic activity of SmE-SeNPs against breast (MCF-7) cancer cells DOI

Sara Chetehouna,

Samir Derouiche, Islam Boulaares

et al.

Biocatalysis and Agricultural Biotechnology, Journal Year: 2024, Volume and Issue: 57, P. 103122 - 103122

Published: March 20, 2024

Language: Английский

Citations

6
The Clothes Matter—Exploiting Agronomical Functions of Trichogenic Selenium Nanoparticles Sharing Activities with Biological Systems Wherein (Were) Formed DOI Creative Commons

Livia Teodora Ciobanu,

Victoria Bînzari,

Ştefan‐Ovidiu Dima

et al.

Agronomy, Journal Year: 2024, Volume and Issue: 14(1), P. 190 - 190

Published: Jan. 15, 2024

The formation of biogenic selenium nanoparticles (SeNPs) through microbial activities is a promising technique that can contribute to the development reliable, non-toxic and environmentally friendly synthesis methods. Among these, under optimal conditions, myconanotechnology confers particular characteristics due generation bioactive fungal metabolites with various bioactivities. formed SeNPs are known be stabilized by biomolecules microorganism, forming so-called bio-corona or capping structure. composition this greatly impacts activity, but investigations have been limited date. produced Trichoderma sp. potential applications in crops environmental management, as both benefit cultivated plants phytoremediation. This review summarizes biosynthesis contextualizes possible correlations between Trichoderma; it also provides missing analysis could help understand optimize process. Biosynthesis methods probable mechanisms briefly discussed well role trichogenic plant protectants, biostimulants, safe biofortifying agents. knowledge gaps related biosynthesis, control desired for specific agricultural function, technology scale-up connection needed future research directions.

Language: Английский

Citations

5
Kombucha Versus Vegetal Cellulose for Affordable Mucoadhesive (nano)Formulations DOI Creative Commons
Ioana Popa‐Tudor, Naomi Tritean, Ştefan‐Ovidiu Dima

et al.

Gels, Journal Year: 2025, Volume and Issue: 11(1), P. 37 - 37

Published: Jan. 4, 2025

Cellulose nanofibers gained increasing interest in the production of medical devices such as mucoadhesive nanohydrogels due to their ability retain moisture (high hydrophilicity), flexibility, superior porosity and durability, biodegradability, non-toxicity, biocompatibility. In this work, we aimed compare suitability selected bacterial vegetal nanocellulose form hydrogels for biomedical applications. The cellulose were synthesized from brewer's spent grains (BSG) kombucha membranes, respectively. Two prepared, one based on other (VNC BNC, respectively). VNC was less opaque more fluid than BNC. cytocompatibility vitro antioxidant activity nanocellulose-based investigated using human gingival fibroblasts (HGF-1, ATCC CRL-2014). investigation hydrogel-mucin interaction revealed that BNC hydrogel had an approx. 2× higher mucin binding efficiency at a hydrogel/mucin ratio (mg/mg) = 4. exhibited highest potential increase number metabolically active viable cells (107.60 ± 0.98% cytotoxicity negative control) among all culture conditions. reduced amount reactive oxygen species (ROS) by about 23% (105.5 2.2% C-) comparison with positive control, whereas ROS level slightly (120.2 3.9% following treatment. Neither two showed antibacterial when assessed diffusion method. data suggest fermentation could be better candidate cytocompatible nanoformulations grains. both VNC, respectively, should improved.

Language: Английский

Citations

0
Synergistic Role of Vitamins and Bioactive Compounds in Sea Buckthorn DOI Creative Commons

Maria-Zinaida Dobre,

Bogdana Vîrgolici,

Daciana Costina Andrada Stefan

et al.

IntechOpen eBooks, Journal Year: 2025, Volume and Issue: unknown

Published: March 4, 2025

Sea buckthorn (SB) offers remarkable health benefits through the synergistic actions of its bioactive compounds. High levels vitamin C, carotenoids and flavonoids enhance neurogenesis, reduce neuroinflammation support collagen synthesis. This synergy extends to gut health, fostering beneficial bacteria reducing oxidative stress. SB’s balanced profile essential fatty acids further amplifies bioavailability effectiveness fat-soluble vitamins. Omega-7, for example, works in concert with E promote skin regeneration damage, while omega-3 omega-6 modulate inflammatory responses antioxidant functions vitamins A E. Rich antioxidants like polyphenols lycopene, SB combats damage supports cardiovascular solidifying status as a functional superfood.

Language: Английский

Citations

0
67th International Open Readings Conference for students of Physics and Natural Sciences. Annual Abstract Book 2024 DOI Open Access

Martynas Keršys,

Rimantas Naina,

V. A. Adomaitis

et al.

Vilnius University Proceedings, Journal Year: 2024, Volume and Issue: 46, P. 1 - 410

Published: May 31, 2024

“Open Readings 2024” is an international academic platform for students and young researchers worldwide to present their ongoing research results practices in physics natural sciences. The 67th International Scientific Conference Students of Physics Natural Sciences brings together participants discuss, learn, exchange, share scientific experiences, meet key experts, enjoy exciting program. conference features lectures by well-known, leading, accomplished scientists, as well presentations students’ research. offers BSc, MSc, PhD opportunity a larger audience receive constructive criticism helpful advice. This book provides overview all the at Open 2024 conference.

Language: Английский

Citations

1
Bioactive Hydrogel Formulation Based on Ferulic Acid-Grafted Nano-Chitosan and Bacterial Nanocellulose Enriched with Selenium Nanoparticles from Kombucha Fermentation DOI Creative Commons
Naomi Tritean,

Luminița Dimitriu,

Ştefan‐Ovidiu Dima

et al.

Journal of Functional Biomaterials, Journal Year: 2024, Volume and Issue: 15(7), P. 202 - 202

Published: July 22, 2024

Selenium nanoparticles (SeNPs) have specific properties that result from their biosynthesis particularities. Chitosan can prevent pathogenic biofilm development. A wide palette of bacterial nanocellulose (BNC) biological and physical-chemical are known. The aim this study was to develop a hydrogel formulation (SeBNCSFa) based on ferulic acid-grafted chitosan enriched with SeNPs Kombucha fermentation (SeNPsK), which could be used as an adjuvant for oral implant integration other applications. grafted SeBNCSFa were characterized by biochemical methods. cell viability proliferation HGF-1 gingival fibroblasts investigated, well in vitro antioxidant activity. inflammatory response determined enzyme-linked immunosorbent assay (ELISA) the proinflammatory mediators (IL-6, TNF-α, IL-1β) culture medium. Likewise, amount nitric oxide released measured Griess reaction. antimicrobial activity also investigated. grafting degree acid approximately 1.780 ± 0.07% total monomeric units, assuming single-site per monomer. Fourier-transform infrared spectroscopy evidenced convolution BNC spectra, X-ray diffraction analysis highlighted amorphous rearrangement patterns, suggesting multiple interactions. showed high cytocompatibility, enhanced antioxidant, anti-inflammatory, potentials.

Language: Английский

Citations

1