Methylene Blue Has Strong Extracellular Virucidal Activity Against a SARS-CoV-2-Related Pangolin Coronavirus with No Intracellular or In Vivo Efficacy DOI Creative Commons

Lai Wei,

Yu Ma, Yuhao Ren

et al.

Pathogens, Journal Year: 2024, Volume and Issue: 13(11), P. 958 - 958

Published: Nov. 4, 2024

Studies have demonstrated that methylene blue exhibits significant antiviral activity against SARS-CoV-2 or related coronaviruses at the cellular level, suggesting its potential as an anti-SARS-CoV-2 drug. Herein, we report does not exhibit noticeable in a lethal model involving SARS-CoV-2-related pangolin coronavirus GX_P2V (short_3UTR) infection CAG-hACE2 transgenic mice. We employed plaque reduction assays and cell experiments to compare extracellular virucidal of compound ability inhibit viral replication cells those nirmatrelvir. Methylene strong but did cells. The control nirmatrelvir lacked exhibited abilities replication. was further tested mouse plasma. Incubation plasma increased EC

Language: Английский

Photodynamic therapy: An emerging therapeutic modality in dentistry DOI Creative Commons

Nandita Suresh,

Betsy Joseph, Pradeesh Sathyan

et al.

Bioorganic & Medicinal Chemistry, Journal Year: 2024, Volume and Issue: 114, P. 117962 - 117962

Published: Oct. 19, 2024

Language: Английский

Citations

6
Photosensitizer of phthalocyanine-conjugated chitosan-doped nano-silver for inactivation against bacteria and promote wound healing DOI
Wenqing Lai, Huanliang Liu,

Jun Yan

et al.

Biomedical Engineering Advances, Journal Year: 2025, Volume and Issue: 9, P. 100147 - 100147

Published: Feb. 20, 2025

Language: Английский

Citations

0
Illuminating oral health: AIEgens for phototheranostics DOI Creative Commons
Jingyuan Chen, Wenhao Yan, Xinyu Wang

et al.

Published: March 1, 2025

Language: Английский

Citations

0
Natural Photosensitizers DOI
Tomasz Kubrak, David Aebisher

Springer eBooks, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 29

Published: Jan. 1, 2025

Language: Английский

Citations

0
Evaluation of antimicrobial photodynamic activity of CuminUP60®- A commercially-available high-soluble curcumin DOI Creative Commons

Fang Xu,

Jiamiao Hu, Natthida Sriboonvorakul

et al.

LWT, Journal Year: 2024, Volume and Issue: 205, P. 116490 - 116490

Published: July 14, 2024

Curcumin, a polyphenol extracted from Curcuma longa L. with variety of biological and pharmacological activities, has been identified as promising photosensitizer for food sterilization. However, its low aqueous solubility bioavailability greatly restrict the practical application curcumin. In last decades, number approaches have proposed to address this challenge, several having already attained notable commercial viability. CuminUP60®, patented curcumin complex consisting extract Poloxam407, gathered attention in realms enhanced solubility, therapeutic potential. antimicrobial photodynamic activity novel not investigated. current study, we found that CuminUP60® showed maximum absorption intensity at 434 nm capability produce Reactive Oxygen Species (ROS) upon blue light excitation. Furthermore, desirable bactericidal against range typical foodborne bacteria including Staphylococcus aureus, Listeria monocytogenes Vibrio parahaemolyticus, Shewanella putrefaciens, Pseudomonas fluorescens (MIC = 83.33 μM) Escherichia coli 166.66 (5.3 mW/cm2) illumination 30 min. Taken together, results demonstrated possess antibacterial activity, which could provide crucial support development industrially applicable sterilization systems within industry.

Language: Английский

Citations

3
Phytochemical-based nanosystems: recent advances and emerging application in antiviral photodynamic therapy DOI
Yan Shan Loo,

Nur Aininie Yusoh,

Wai Feng Lim

et al.

Nanomedicine, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 16

Published: Jan. 23, 2025

Phytochemicals are typically natural bioactive compounds or metabolites produced by plants. Phytochemical-loaded nanocarrier systems, designed to overcome bioavailability limitations and enhance therapeutic effects, have garnered significant attention in recent years. The coronavirus disease 2019 (COVID-19) pandemic has intensified interest the application of phytochemicals combat viral infections. This review explores nanoparticle-based treatment strategies incorporating for antiviral application, highlighting their demonstrated mechanisms. It specifically examines activities phytochemical-loaded nanosystems against (i) influenza virus (IAV), respiratory syncytial (RSV), severe acute syndrome 2 (SARS-CoV-2); (ii) mosquito-borne viruses [dengue (DENV), Zika (ZIKV), Chikungunya (CHIKV)]; (iii) sexually transmitted/blood borne [e.g. herpes simplex (HSV), human papillomavirus (HPV), immunodeficiency (HIV)]. Furthermore, this highlights emerging role these photodynamic therapy (PDT)-mediated attenuation proliferation, offers a perspective on future directions research promising area multimodal approach.

Language: Английский

Citations

0
Natural Photosensitizers in Clinical Trials DOI Creative Commons
David Aebisher,

Agnieszka Przygórzewska,

Dorota Bartusik‐Aebisher

et al.

Applied Sciences, Journal Year: 2024, Volume and Issue: 14(18), P. 8436 - 8436

Published: Sept. 19, 2024

Photodynamic therapy (PDT) is a minimally invasive therapeutic method with high selectivity of action. It has gained great popularity in recent years as new for the treatment cancer, but also used dermatology, ophthalmology, and antimicrobial treatment, among others. The regimen involves administration photosensitizer (PS) that selectively accumulates tumor cells or present blood vessels prior to irradiation light at wavelength corresponding absorbance photosensitizer, leading generation reactive oxygen species (ROS). Choosing right PS one most important steps PDT crucial effectiveness therapy. Despite many compounds discovered, search molecules could fulfill functions an optimal improve efficiency still ongoing. Compounds natural origin contribute achieving this goal. A number photoactive substances effective synthetic photosensitizers have been described various plant fungal species. With increasing identification products, are expected emerge. Some already clinically tested promising results. In our work, we provide insights into research molecules, analyze their advantages disadvantages, point out gaps current knowledge future directions development. We not yet clinical trials potential

Language: Английский

Citations

2
Comparison of the Effect of Photodynamic Therapy with Curcumin and Methylene Blue Staining on the Lactobacillus Bacteria Colonies DOI

Hanieh Jadidi,

Haleh Molaahmadi,

Arash Rahimi

et al.

Published: Jan. 1, 2024

Language: Английский

Citations

0
Methylene Blue Has Strong Extracellular Virucidal Activity Against a SARS-CoV-2-Related Pangolin Coronavirus with No Intracellular or In Vivo Efficacy DOI Creative Commons

Lai Wei,

Yu Ma, Yuhao Ren

et al.

Pathogens, Journal Year: 2024, Volume and Issue: 13(11), P. 958 - 958

Published: Nov. 4, 2024

Studies have demonstrated that methylene blue exhibits significant antiviral activity against SARS-CoV-2 or related coronaviruses at the cellular level, suggesting its potential as an anti-SARS-CoV-2 drug. Herein, we report does not exhibit noticeable in a lethal model involving SARS-CoV-2-related pangolin coronavirus GX_P2V (short_3UTR) infection CAG-hACE2 transgenic mice. We employed plaque reduction assays and cell experiments to compare extracellular virucidal of compound ability inhibit viral replication cells those nirmatrelvir. Methylene strong but did cells. The control nirmatrelvir lacked exhibited abilities replication. was further tested mouse plasma. Incubation plasma increased EC

Language: Английский

Citations

0