Acute Quetiapine Intoxication: Relationship Between Ingested Dose, Serum Concentration and Clinical Presentation—Structured Literature Review and Analysis DOI Creative Commons
Matej Dobravc Verbič, Iztok Grabnar, Florian Eyer

et al.

Journal of Xenobiotics, Journal Year: 2024, Volume and Issue: 14(4), P. 1570 - 1594

Published: Oct. 18, 2024

Over the past decade, quetiapine has become one of most commonly used psychotropic drugs in acute intoxication events worldwide. A structured literature review and analysis were conducted to assess relationship between kinetic dynamic profiles intoxication. The correlation dose peak serum concentration (cmax) was determined using Pearson’s coefficient. Binary logistic regression evaluate cmax as predictors common clinical events, signs symptoms. One hundred thirty-four cases ingestion included analysis, with a median ingested 10 g 4 mg/L. typical half-life estimated be 16.5 h, significantly longer than at therapeutic doses. For immediate-release formulation, biphasic disposition could not excluded. Dose demonstrated weak but significant (r = 0.256; N 63; p 0.043). Central nervous system depression tachycardia signs. Higher doses concentrations increased risk severe good intubation, tachycardia, hypotension, QTc prolongation seizures, QRS prolongation, arrhythmia, heart block, hypokalaemia or acidosis. thresholds for that individual symptoms varied widely. However, > 3 2 mg/L can considered alert levels represent high course

Language: Английский

National Real-Time Surveillance System for Suicide Attempts in Uruguay: Results from the First Year of Implementation DOI Creative Commons

Karina Rando,

Laura de Álava, Denisse Dogmanas

et al.

Psychiatry International, Journal Year: 2025, Volume and Issue: 6(1), P. 33 - 33

Published: March 12, 2025

Suicide is a major public health concern, and Uruguay has one of the highest suicide mortality rates in Americas. In 2022, Ministry Public Health implemented real-time digital surveillance system for attempts as part National Prevention Strategy. This study presents findings from its first year, analysing 4723 emergency department presentations nationwide. The age-standardised attempt rate was 140.44 per 100,000 inhabitants, with women accounting 71.6% cases. Self-poisoning most common method, followed by hanging suffocation men self-cutting women. Nearly half all involved individuals aged 15–29, highlighting need youth-focused gender-sensitive interventions. demonstrates value systems identifying at-risk groups, informing prevention efforts, supporting timely While some challenges implementation remain, future efforts should focus on strengthening data integration, leveraging artificial intelligence risk assessment, improving follow-up care to reduce repeated overall mortality.

Language: Английский

Citations

0
Development and internal validation of a predictive model for prolonged intensive care unit stays in patients with psychotropic drug poisoning DOI
Qifang Shi,

Huishui Dai,

Gen Ba

et al.

Heart & Lung, Journal Year: 2024, Volume and Issue: 68, P. 350 - 358

Published: Sept. 10, 2024

Language: Английский

Citations

0
Acute Quetiapine Intoxication: Relationship Between Ingested Dose, Serum Concentration and Clinical Presentation—Structured Literature Review and Analysis DOI Creative Commons
Matej Dobravc Verbič, Iztok Grabnar, Florian Eyer

et al.

Journal of Xenobiotics, Journal Year: 2024, Volume and Issue: 14(4), P. 1570 - 1594

Published: Oct. 18, 2024

Over the past decade, quetiapine has become one of most commonly used psychotropic drugs in acute intoxication events worldwide. A structured literature review and analysis were conducted to assess relationship between kinetic dynamic profiles intoxication. The correlation dose peak serum concentration (cmax) was determined using Pearson’s coefficient. Binary logistic regression evaluate cmax as predictors common clinical events, signs symptoms. One hundred thirty-four cases ingestion included analysis, with a median ingested 10 g 4 mg/L. typical half-life estimated be 16.5 h, significantly longer than at therapeutic doses. For immediate-release formulation, biphasic disposition could not excluded. Dose demonstrated weak but significant (r = 0.256; N 63; p 0.043). Central nervous system depression tachycardia signs. Higher doses concentrations increased risk severe good intubation, tachycardia, hypotension, QTc prolongation seizures, QRS prolongation, arrhythmia, heart block, hypokalaemia or acidosis. thresholds for that individual symptoms varied widely. However, > 3 2 mg/L can considered alert levels represent high course

Language: Английский

Citations

0