Exploring the antiproliferative and proapoptotic activities of new pyridopyrimidine derivatives and their analogs DOI

Hadeer M. Ali,

Mohamed A. Said, Shady Allam

et al.

Bioorganic & Medicinal Chemistry, Journal Year: 2024, Volume and Issue: 118, P. 118053 - 118053

Published: Dec. 28, 2024

Language: Английский

A novel approach utilizing spirocyclic thiopyrimidinone compounds against herpes simplex virus with underlying antiviral mechanisms of action DOI Creative Commons

Esraa A. Manie,

Emad M. Elzayat,

Sherif S. Ragab

et al.

Virology Journal, Journal Year: 2025, Volume and Issue: 22(1)

Published: April 11, 2025

Abstract In recent decades, viral outbreaks have significantly threatened global health, with herpes simplex virus type 2 (HSV-2) being one of the most prevalent infections. This study evaluated novel spiropyrimidine derivatives as potential antiviral agents against HSV-2, building on previous research that examined spirocyclic thiopyrimidinone human coronavirus 229E (hCoV-229E). Among eleven synthesized compounds, spiropyrimidinone derivative 3 demonstrated promising activity, a selectivity index 11.2. The drug mechanism infection studies indicated compound primarily inhibits HSV-2 at adsorption stage, achieving approximately 83% inhibition and reducing multiplication by 34%. Its efficacy is linked to its diketone moiety, which known for ability enhance effects. Furthermore, effect reflected in level caspase-3 protein expression, revealing apoptotic pathway modulated. Docking revealed multiple interactions entry mediator (HVEM), indicating an inhibitor. These findings confirm could be candidate further development therapy. Graphical

Language: Английский

Citations

0
Facile and Novel Synthetic Approach, Molecular Docking, Molecular Dynamics, and Drug‐Likeness Evaluation of 9‐Substituted Acridine Derivatives as Dual Anticancer and Antimicrobial Agents DOI

Mohamed G. Abouelenein,

Mahmoud Basseem I. Mohamed, Mohamed M. Elsenety

et al.

Chemistry & Biodiversity, Journal Year: 2024, Volume and Issue: 21(5)

Published: March 13, 2024

Abstract In the present study, numerous acridine derivatives A1 – A20 were synthesized via aromatic nucleophilic substitution (S NAr ) reaction of 9‐chloroacridine with carbonyl hydrazides, amines, or phenolic depending upon facile, novel, and eco‐friendly approaches (Microwave ultrasonication assisted synthesis). The structures new compounds elucidated using spectroscopic methods. title products assessed for their antimicrobial, antioxidant, antiproliferative activities assays. Promisingly, investigated mainstream revealed promising antibacterial anticancer activities. Thereafter, compounds’ expected mode action was debated by an array in silico studies. Compounds A2 A3 most antimicrobial agents, while , A5 A7 cytotoxic Accordingly, RMSD, RMSF, Rg, SASA analyses performed, MMPBSA calculated. Lastly, ADMET (absorption, distribution, metabolism, excretion, toxicity) novel investigated. tested existing screening results afford inspiring basis leading to developing compelling agents based on scaffold.

Language: Английский

Citations

3
Aqueous TPGS-750-M-mediated synthesis of pyrano[2,3-c]-pyrazoles: a sustainable and efficient approach DOI Creative Commons
Adnan Çetin,

Mehmet Yasin Bayden

Research on Chemical Intermediates, Journal Year: 2024, Volume and Issue: 50(6), P. 2827 - 2840

Published: April 23, 2024

Abstract The article describes a green and efficient synthesis method for pyrano[2,3-c]-pyrazoles, employing DL-alpha-tocopherol methoxypolyethylene glycol succinate solution (TPGS-750-M) as biodegradable surfactant in water. utilization of water reaction medium TPGS-750-M obviates the necessity organic solvents, thereby enhancing environmental sustainability synthesis. compounds synthesized using this novel was characterized various spectroscopic techniques, including 1 H-NMR, 13 C-NMR, mass spectrometry. Graphical abstract

Language: Английский

Citations

3
Molecular Investigations of Novel Pyrano[2,3-c]Pyrazole Congeners as Potential HCoV-229E Inhibitors: synthesis, Molecular Modeling, 3D QSAR, and ADMET Screening DOI

Mohamed G. Abouelenein,

Aliaa H. El-boghdady,

Hadeer M. Ali

et al.

Polycyclic aromatic compounds, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 18

Published: Sept. 11, 2024

Language: Английский

Citations

2
Recent Highlights in the Synthesis and Biological Significance of Pyrazole Derivatives DOI Creative Commons
Ziad Moussa, Mani Ramanathan,

Shaikha Mohammad Alharmoozi

et al.

Heliyon, Journal Year: 2024, Volume and Issue: 10(20), P. e38894 - e38894

Published: Oct. 1, 2024

Language: Английский

Citations

1
Exploring the antiproliferative and proapoptotic activities of new pyridopyrimidine derivatives and their analogs DOI

Hadeer M. Ali,

Mohamed A. Said, Shady Allam

et al.

Bioorganic & Medicinal Chemistry, Journal Year: 2024, Volume and Issue: 118, P. 118053 - 118053

Published: Dec. 28, 2024

Language: Английский

Citations

0