Biomedical Reports, Journal Year: 2024, Volume and Issue: 22(2)

Published: Dec. 19, 2024

Silver nanoparticles (AgNPs) are spherical particles with a number of specific and unique physical (such as surface plasmon resonance, high electrical conductivity thermal stability) well chemical (including antimicrobial activity, catalytic efficiency the ability to form conjugates biomolecules) properties. These properties allow AgNPs exhibit desired interactions biological system make them prospective candidates for use in antibacterial anticancer activities. have quenching capacity, which produces reactive oxygen species disrupts cellular processes reducing function mitochondria, damaging cell membrane, inhibiting DNA replication altering protein synthesis). In addition, sponge extracts contain biologically active substances therapeutic effects. Therefore, concurrent these agents may present potential development novel antitumor drugs. The study investigated cytotoxic effects combined from species, Stylissa carteri or Amphimedon chloros, against various cancer lines pathogenic bacterial strains. was it provided further understanding cytotoxicity underlying mechanisms AgNPs. Alterations properties, such size, charge polydispersity index, were demonstrated after lyophilization. Scanning electron microscopy revealed submicron‑sized particles. across lung, colorectal, breast pancreatic lines, demonstrated, especially when extracts, suggested synergistic effect. Analysis using liquid chromatography‑mass spectrometry key components molecular docking simulations indicated inhibition between extract epidermal growth factor receptor tyrosine kinase A. Synergistic several Staphylococcus xylosus, Klebsiella oxytoca, Enterobacter aerogenes, Micrococcus spp. Escherichia coli, observed ethyl acetate extracts. results application marine‑derived compounds nanotechnology combating infections. Future research should elucidate mechanistic pathways investigate in vivo efficacy.

Language: Английский