Exploring
innovations
in
geriatric
oncology,
this
article
focuses
on
recent
developments
palliative
care
for
elderly
cancer
patients.It
highlights
the
importance
of
personalized
approaches
and
integration
innovative
practices
such
as
telemedicine
complementary
therapies,
aimed
at
improving
patients'
quality
life.Current
challenges,
including
equitable
access
effective
implementation
care,
are
discussed,
concluding
with
need
ongoing
adaptation
enhancement
oncology.
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(9), P. 4769 - 4769
Published: April 27, 2024
Contemporary
living
is
continuously
leading
to
poor
everyday
choices
resulting
in
the
manifestation
of
various
diseases.
The
benefits
plant-based
nutrition
are
undeniable
and
research
on
topic
rising.
Modern
man
now
aware
possibilities
that
plant
can
provide
seeking
ways
benefit
from
it.
Dietary
phenolic
compounds
among
easily
accessible
beneficial
substances
exhibit
antioxidant,
anti-inflammatory,
antitumor,
antibacterial,
antiviral,
antifungal,
antiparasitic,
analgesic,
anti-diabetic,
anti-atherogenic,
antiproliferative,
as
well
cardio-and
neuroprotective
activities.
Several
industries
exploring
incorporate
biologically
active
their
produce.
This
review
concentrated
presenting
current
information
about
dietary
contribution
maintaining
good
health.
Additionally,
this
content
will
demonstrate
importance
prosperity
natural
for
fields,
i.e.,
food
industry,
cosmetology,
biotechnology,
others.
International Journal of Molecular Sciences,
Journal Year:
2025,
Volume and Issue:
26(3), P. 1002 - 1002
Published: Jan. 24, 2025
Scientific
research
on
stilbenes
is
conducted
for
their
chemopreventive
and
therapeutic
properties.
In
experimental
studies,
natural
synthetic
trans-stilbenes
exhibit
antioxidant,
anti-inflammatory,
cardioprotective,
anticancer
effects.
The
antitumor
activity
of
some
associated
with
interaction
cytochrome
P450
family
1,
which
leads
to
the
inhibition
procarcinogen
activation.
present
study,
three-dimensional
quantitative
structure–activity
relationship
analysis
(3D-QSAR)
was
performed
a
series
forty-one
trans-stilbene
derivatives
identify
most
significant
features
molecules
responsible
CYP1B1
inhibitory
activity.
developed
3D-QSAR
model
presented
cross-validated
correlation
coefficient
Q2
0.554.
model’s
predictive
ability
confirmed
by
external
validation
(r2
=
0.808).
information
provided
expected
be
valuable
rational
design
novel
inhibitors.
Antioxidants,
Journal Year:
2025,
Volume and Issue:
14(2), P. 181 - 181
Published: Feb. 4, 2025
The
interest
in
new
sources
of
bioactive
compounds
has
been
driven
by
the
search
for
natural
antioxidants
capable
attenuating
toxicity
reactive
oxygen
species,
as
well
emergence
pathogens
resistant
to
antimicrobials.
In
this
sense,
we
explored
potential
macaúba
epicarp.
Compounds
such
piceatannol,
3,4,5,3′,5′-penta-hydroxy-trans-stilbene
(PHS),
and
lower
amounts,
resveratrol
were
identified
extracts
through
techniques
medium-pressure
liquid
chromatography,
HPLC-MS,
imaging
mass
spectrometry
(IMS),
which
confirmed
exclusive
localization
PHS
piceatannol
outer
Extraction
with
aqueous
acetone
(Me2CO:H2O)
its
EtOAC
fraction
showed
highest
yields
stilbenes
and,
moreover,
it
efficiently
increased
tolerance
Saccharomyces
cerevisiae
oxidative
stress.
Additionally,
Me2CO:H2O
extract
presented
antibacterial
anti-cryptococcal
activity,
increasing
survival
rates
Galleria
mellonella
subjected
fungal
infection.
silico
ADMET
(absorption,
distribution,
metabolism,
excretion
toxicity)
analysis
indicates
low
PHS,
resveratrol,
addition
pharmacokinetic
parameters
that
allow
their
use.
These
findings
indicate
use
epicarp
a
source
valuable
food,
cosmetic,
pharmaceutical
industries.
Molecules,
Journal Year:
2025,
Volume and Issue:
30(9), P. 1982 - 1982
Published: April 29, 2025
This
review
covers
preclinical
studies
of
stilbene
derivative
compounds
(both
natural
and
synthetic)
with
potential
preventive
therapeutic
effects
against
Alzheimer’s
disease
(AD).
AD
is
a
worldwide
neurodegenerative
characterized
by
the
destruction
nerve
cells
in
brain
loss
cognitive
function
due
to
aging.
Stilbenes
are
unique
class
phenolic
distinguished
C6-C2-C6
(1,2-diphenylethylene)
structure
two
aromatic
rings
connected
an
ethylene
bridge.
Stilbenes’
distinct
features
make
them
intriguing
subject
for
pharmacological
research
development.
Several
have
suggested
that
stilbenes
may
neuroprotective
reducing
Aβ
generation
oligomerization,
enhancing
clearance,
regulating
tau
neuropathology
through
prevention
aberrant
phosphorylation
aggregation,
as
well
scavenging
reactive
oxygen
species.
Synthetic
derivatives
also
target
multiple
pathways
involved
neuroprotection
demonstrated
promising
biological
activity
vitro.
However,
some
properties
stilbenes,
such
sensitivity
physiological
conditions,
low
solubility,
poor
permeability,
instability,
bioavailability,
limit
their
usefulness
clinical
applications.
To
address
this
issue,
current
investigations
developed
new
drug
delivery
systems
based
on
molecules.
aims
shed
light
development
next-generation
treatment
strategies
examining
detail
role
pathophysiology
potential.
Plants,
Journal Year:
2025,
Volume and Issue:
14(10), P. 1459 - 1459
Published: May 14, 2025
Stilbenes
are
plant
secondary
metabolites
with
remarkable
antidiabetic,
anti-inflammatory,
antimicrobial,
antioxidant,
antitumor,
and
neuroprotective
properties.
As
these
compounds
valuable
constituents
in
healthcare
products
promising
drug
candidates,
exploring
new
sources
of
stilbenes
is
essential
for
therapeutic
advancement.
The
present
study
reports
the
isolation
two
stilbene
glycosides,
resveratroloside
pinostilbenoside,
from
Pinus
cembra
L.
bark.
Their
antioxidant
activity
cytotoxic
effects
against
HeLa
cells
were
evaluated
comparison
to
raw
bark
extract.
structures
pinostilbenoside
confirmed
by
nuclear
magnetic
resonance
(NMR)
mass
spectrometry
(MS)
data
analyses.
Antioxidant
was
assessed
2,2-diphenyl-1-picrylhydrazyl
(DPPH)
radical
scavenging
reducing
power
assays.
Cell
viability,
apoptosis,
cell
proliferation,
cycle
assays
used
evaluate
potential
cells.
Resveratroloside
exhibited
lower
as
free
scavengers
agents.
However,
they
showed
greater
efficacy
viability
suppressing
proliferation
human
cervical
carcinoma
Given
findings
our
study,
should
be
further
investigated.
