Antiviral Activity of Ecklonia cava Extracts and Dieckol Against Zika Virus DOI Open Access
Eun‐A Kim,

Nalae Kang,

Jun‐Ho Heo

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(24), P. 13694 - 13694

Published: Dec. 21, 2024

Ecklonia cava and its major compound dieckol, both natural marine products, possess antioxidant, anti-inflammatory, metabolic-regulating effects. Zika virus (ZIKV), an arbovirus from the Flaviviridae family, is transmitted by mosquitoes causes serious illnesses in humans. This study aimed to evaluate anti-ZIKV potential of dieckol. The antiviral activity extract (ECE), prepared with 80% ethanol, was assessed ZIKV-infected Vero E6 cells through MTT assay, plaque quantitative polymerase chain reaction (qPCR), demonstrating no cytotoxicity a significant reduction viral titers ZIKV mRNA levels. In addition, ECE decreased expression tumor necrosis factor-α interferon-induced protein tetratricopeptide repeats cells. Dieckol, primary active ECE, exhibited potent activity, half maximal inhibitory concentration (IC50), value 4.8 µM. silico molecular docking analysis revealed that dieckol forms stable complexes key proteins, including envelope, NS2B/NS3, RNA-dependent RNA (RdRp) protein, exhibiting high binding energies -438.09 kcal/mol, -1040.51 -1043.40 respectively. Overall, our findings suggest are promising candidates for development agents.

Language: Английский

Glucoregulatory Properties of a Protein Hydrolysate from Atlantic Salmon (Salmo salar): Preliminary Characterization and Evaluation of DPP-IV Inhibition and Direct Glucose Uptake In Vitro DOI Creative Commons

Christian Bjerknes,

Sileshi Gizachew Wubshet, Sissel Beate Rønning

et al.

Marine Drugs, Journal Year: 2024, Volume and Issue: 22(4), P. 151 - 151

Published: March 28, 2024

Metabolic disorders are increasingly prevalent conditions that manifest pathophysiologically along a continuum. Among reported metabolic risk factors, elevated fasting serum glucose (FSG) levels have shown the most substantial increase in exposure. Ultimately leading to insulin resistance (IR), this condition is associated with notable deteriorations prognostic outlook for major diseases, including neurodegenerative cancer risk, and mortality related cardiovascular disease. Tackling dysfunction, focus on prevention, critically important aspect human health. In study, an investigation into potential antidiabetic properties of salmon protein hydrolysate (SPH) was conducted, focusing its dipeptidyl peptidase-IV (DPP-IV) inhibition direct uptake vitro. Characterization SPH utilized bioassay-guided fractionation approach identify potent glucoregulatory peptide fractions. Low-molecular-weight (MW) fractions prepared by membrane filtration (MWCO = 3 kDa) showed significant DPP-IV (IC50 1.01 ± 0.12 mg/mL) vitro (p ≤ 0.0001 at 1 mg/mL). Further lowest MW (<3 derived from permeate resulted three subfractions. The subfraction molecular weight demonstrated activity 0.0001), maintaining potency even dilution 1:500 0.01).

Language: Английский

Citations

7
Recent advances of edible marine algae-derived sulfated polysaccharides in antiviral treatments: challenges vs. opportunities DOI Creative Commons
Xiaoying Dong, Yufan Qiu, Nan Jia

et al.

Frontiers in Nutrition, Journal Year: 2025, Volume and Issue: 12

Published: March 26, 2025

Marine polysaccharides, particularly those derived from red, brown, and green algae, have shown promising antiviral activity. Among them, sulfated polysaccharides are notable due to their broad-spectrum properties. These include direct viral destruction, inhibition of virus adsorption, disruption transcription replication, the stimulation host’s immunity. With low toxicity, minimal drug resistance, excellent biocompatibility, these represent candidates for development medications. For instance, carrageenan, a polysaccharide red fucoidan, polymer brown both been proven effectively inhibit infections. Sulfated such as found in Ulva species, also exhibit properties, including activity against Japanese encephalitis virus. function by blocking attachment viruses host cells or interfering with various stages life cycle. Moreover, marine enhance immune responses, thereby aiding clearance. Although findings highlight potential most studies conducted vitro animal models. Further clinical trials necessary validate effectiveness safety therapeutic use.

Language: Английский

Citations

0
Exploring the Capabilities of Marine Metabolites DOI
Kankan Majumdar, Awadhesh Kumar Verma,

Karishma Vivek Kathpalia

et al.

Advances in medical technologies and clinical practice book series, Journal Year: 2024, Volume and Issue: unknown, P. 117 - 146

Published: Sept. 25, 2024

Cancer is a pathological condition characterized by the uncontrolled growth and dissemination of certain cells inside body. Currently, cancer poses significant global challenge. The marine ecosystem bountiful reservoir biologically potent compounds that carry enormous promise for treatment various ailments, particularly cancer. anticancer properties natural have been previously demonstrated in both laboratory animal investigations. field marine-based pharmaceuticals has begun to an influence on current pharmacology. Various anti-cancer therapies are developed from components officially approved clinical usage. This book chapter specifically examines bioactive obtained habitats properties. It also explores therapeutic applications these molecules wide range innovative sources species purposes.

Language: Английский

Citations

0
Oceanic Breakthroughs: Marine-Derived Innovations in Vaccination, Therapy, and Immune Health DOI Creative Commons
Chiara Gamberi,

Chad L. Leverette,

Aubrey K. Davis

et al.

Vaccines, Journal Year: 2024, Volume and Issue: 12(11), P. 1263 - 1263

Published: Nov. 8, 2024

The vast, untapped potential of the world's oceans is revealing groundbreaking advancements in human health and vaccination. Microalgae such as

Language: Английский

Citations

0
Antiviral Activity of Ecklonia cava Extracts and Dieckol Against Zika Virus DOI Open Access
Eun‐A Kim,

Nalae Kang,

Jun‐Ho Heo

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(24), P. 13694 - 13694

Published: Dec. 21, 2024

Ecklonia cava and its major compound dieckol, both natural marine products, possess antioxidant, anti-inflammatory, metabolic-regulating effects. Zika virus (ZIKV), an arbovirus from the Flaviviridae family, is transmitted by mosquitoes causes serious illnesses in humans. This study aimed to evaluate anti-ZIKV potential of dieckol. The antiviral activity extract (ECE), prepared with 80% ethanol, was assessed ZIKV-infected Vero E6 cells through MTT assay, plaque quantitative polymerase chain reaction (qPCR), demonstrating no cytotoxicity a significant reduction viral titers ZIKV mRNA levels. In addition, ECE decreased expression tumor necrosis factor-α interferon-induced protein tetratricopeptide repeats cells. Dieckol, primary active ECE, exhibited potent activity, half maximal inhibitory concentration (IC50), value 4.8 µM. silico molecular docking analysis revealed that dieckol forms stable complexes key proteins, including envelope, NS2B/NS3, RNA-dependent RNA (RdRp) protein, exhibiting high binding energies -438.09 kcal/mol, -1040.51 -1043.40 respectively. Overall, our findings suggest are promising candidates for development agents.

Language: Английский

Citations

0