Features of the pathogenesis, diagnosis and treatment of myocardial ischemia with non-obstructive coronary arteries

Eurasian heart journal, Journal Year: 2025, Volume and Issue: 1, P. 50 - 57

Published: March 4, 2025

Among the most dangerous causes of mortality worldwide, coronary artery disease (CAD) remains leading cause. Despite fact that atherosclerosis arteries is main cause development disease, clinicians are increasingly identifying myocardial ischemia without obstruction. Myocardial with non-obstructive (INOCA) characterized by clinical signs infarction (MI) evidence stenosis on angiography less than 50%. In recent years, significant advances have been made in understanding pathophysiological changes underlie this condition, but predictors condition remain unclear. And a diagnosis INOCA difficult task for clinician to day. Determining mechanism and excluding other possible elevated cardiac troponin important secondary prevention measures aimed at improving prognosis patients after acute (AMI). A history use invasive noninvasive imaging should lead identification vasospastic or microvascular their differentiation from injury caused diseases. Compared AMI due obstructive (CAD), more often women tend fewer traditional cardiovascular (CVD) risk factors. The aim article was review literature evaluate features, ethiology, diagnosis, treatment, INOCA. This summarizes current knowledge areas epidemiology, pathophysiology an emphasis modern diagnostic tools disease.

Language: Английский

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Effects of trimetazidine on oxidant-antioxidant balance and angiogenesis; an in vivo experimental study

BMC Cardiovascular Disorders, Journal Year: 2025, Volume and Issue: 25(1)

Published: April 10, 2025

We evaluated the effects of trimetazidine (TMZ) on oxidative-antioxidative balance and angiogenesis in an vivo experimental model. This study aims to evaluate through histological analysis assess its impact biochemical measurements. In this study, Ross 308 breed chicken eggs (n = 40) were used, embryos divided into four distinct groups. On eighth day incubation, vascular density was examined. Following assessment development, 4-5 mL albumin collected via syringe measure oxidative stress markers. Each group consisted 10 embryos, with a total 40 used study. The groups organized as follows: Control Group (CG), Bevacizumab (BC), Trimetazidine 10⁻⁴ Group, 10⁻⁵ Group. When capacity (TOC) levels compared among groups, bevacizumab exhibited significantly higher values than control (p < 0.05). index (OSI) measurements, also showed contrast, when antioxidant (TAC) compared, both demonstrated Regarding scoring, significant anti-angiogenic effect group. However, no statistically difference observed between > activity Chorioallantoic Membrane (CAM) model at M concentrations. positive or negative detected. believe that real-time observation our provided value research.

Language: Английский

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Combined the Vitamin E and Trimetazidine Therapy Ameliorate Hepatic Injury from Doxorubicin Administration in Mice

International Journal of Cancer Management, Journal Year: 2025, Volume and Issue: 18(1)

Published: May 6, 2025

Background: Chemotherapy-related hepatotoxicity may weaken the patient so much that desired course of treatment is not achieved. Therefore, it better to combine antioxidant therapy with doxorubicin (DOX). Vitamin E (Vit E) or trimetazidine (TMZ) were administered as antioxidants in this study. Objectives: In study, reparative effects Vit and TMZ administration on DOX-induced investigated. Methods: Animals included 25 male BALB/c mice divided into five groups (n = 5). The sham: No administration; DOX: An accumulative dose mg/kg/i.p. days 12, 13 14 experiment; E: Twice 200 IU/kg PO for 10 followed by DOX therapy; TMZ: Ten mg/kg/day E-TMZ: Administration therapy. On day 15, blood liver tissue samples collected after euthanasia. Aspartate aminotransferase (AST), alanine (ALT), gamma-glutamyl transferase (GGT) levels measured assess severity lesions. Half was examined histopathology. other half total capacity (TAC) malondialdehyde measurements, well examining expression TNFα (inflammation) Bax (apoptosis) genes. Histopathological scoring necrosis, vacuolar degeneration, inflammation from 0 3 based Results: group had most problems. some areas, vacuolation, seen. Liver-related enzymes such GGT, ALT AST increased compared others (P < 0.0001). TAC level only significant between E-TMZ 0.01). MDA highest sham 0.0001), 0.05) 0.01) groups. addition, TNF-α genes appeared higher 0.0001) than normal. Regarding groups, should be noted group, amount damage, liver-related enzymes, but lower group. hand, showed best results terms significance reducing levels, apoptosis. Conclusions: simultaneous use reduces microscopic induced This combination effective inflammatory factor TNF-alpha number apoptotic cells administration.

Language: Английский

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“Emerging clinical approaches in diabetic cardiomyopathy: insights from clinical trials and future directions”

Acta Diabetologica, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 10, 2024

Language: Английский

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Особливості перебігу стенокардії та ведення пацієнтів зі стабільною ішемічною хворобою серця залежно від статі, віку та супутніх клінічних станів у реальній амбулаторній практиці кардіологів України

Ukrainian Journal of Cardiology, Journal Year: 2024, Volume and Issue: 31(4)

Published: Aug. 31, 2024

Objective – to evaluate the features of angina and management outpatients with stable coronary artery disease (CAD) depending on gender, age concomitant arterial hypertension (AH), type 2 diabetes mellitus (T2DM), previous myocardial infarction (postMI) revascularization procedures (CRP) determine further measures optimize such patients.Materials methods. Subanalysis subgroups patients (by sex; AH; T2DM; postMI history CRP) a non-interventional, observational, multicenter prospective study in real outpatient practice cardiologists Ukraine (GO-OD) participation 1529 patients. At inclusion visit (V1) during follow-up visits within 3 months, characteristics patient were analyzed. Results. The analysis included 1448 In women under 55 years age, almost times less often, at 65 older (65+) more often than men, CAD was diagnosed, as well abdominal overweight/obesity (Ov/Ob). Women likely men have typical symptoms angina, emotional stress be provoking factor for attacks. Beta-blockers (BBs), statins, angiotensin-converting enzyme inhibitors (ACEIs) commonly prescribed women, calcium channel blockers (CCBs) prescribed. There 39.6% 64.1% had CRP V1. performed frequently without MI (p < 0.001). PostMI younger 0.001); they active smokers/ former smokers, prediabetes = 0.017) / T2DM 0.030). V1, cholesterol low-density lipoprotein levels exceeded target levels. frequent attacks morning (p=0.007), CCS III pectoris, used short-acting nitrates (SAN). CRP, provoked by physical activity, typical, required SAN (p=0.03). significantly receive BB long-acting nitrates, - CCBs. Approximately 30% both groups received trimetazidine (TMZ). MI, ACEIs/sartans statins frequently. Correction therapy, regardless associated decrease number episodes limitations daily activity. decreased, but group final there three many patients.13.8% They (p=0.055), twice rarely young (p<0.001); 8 renal dysfunction (p<0.001), Ov/Ob (p=0.01). T2DM, 0.038) overeating (p=0.037), occurred 0.001), reached III, p=0.025, limited activity more, p<0.001.71.8% AH hypertensive patients, compared those hypertension, pulse pressure (PP) higher, p<0.001. A significant relationship found between level PP. non-target BP levels, form equivalents (shortness breath), p=0.017. Almost did not statin therapy. Conclusions. diagnosis gender- age-dependent risk factors clinical course should taken into account. insufficient control through lifestyle modification incomplete drug Concomitant common aged 65+ years, Ov/Ob, accompanied dysfunction, morning, after overeating, pectoris. pathomorphological atherosclerosis peculiarities ischemic mechanisms justify feasibility combined antianginal therapy use antiischemic drugs (TMZ).There 2/3 study, 36.3% high PP, which severe angina. BP, breath). AH, additional ischemia hypertrophy considered: reduced threshold due higher oxygen demand, impaired vasomotor endothelial function vessels, capillary bed density wall remodeling. Pathophysiologically, TMZ anti-ischemic effects cardiomyocyte all is justified. visit, vast majority complex TMZ, may component effectiveness control.The improvement emphasizes importance routine monitoring

Language: Английский

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Targeting angiogenic and proliferative mediators by montelukast & trimetazidine Ameliorates thioacetamide-induced liver fibrosis in rats

Toxicology and Applied Pharmacology, Journal Year: 2024, Volume and Issue: unknown, P. 117208 - 117208

Published: Dec. 1, 2024

Language: Английский

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