Jundishapur Journal of Natural Pharmaceutical Products,
Journal Year:
2024,
Volume and Issue:
19(4)
Published: Nov. 10, 2024
Background:
Limitations
in
drug
penetration
are
overcome
by
nanotechnology,
particularly
liposomes,
which
enhance
targeted
administration
of
ocular
medications.
Liposomes
can
augment
the
therapeutic
effects
curcumin,
a
natural
compound
with
positive
impacts
on
retina.
Treatments
for
eye
diseases
also
benefit
from
antibacterial
properties
ozonated
oil
liposomes.
Objectives:
This
study
aims
to
develop
and
evaluate
liposomes
loaded
curcumin
delivery
applications,
specifically
targeting
diabetic
retinopathy
(DR).
Methods:
Liposomal
nanoparticles
were
prepared
using
thin-film
hydration,
incorporating
phospholipids,
lecithin,
cholesterol,
oil,
curcumin.
We
assessed
physicochemical
including
particle
size,
zeta
potential,
encapsulation
efficiency
(EE),
morphology.
Drug
release
profiles
stability
studies
conducted.
Results:
The
optimized
showed
size
84.77
nm,
potential
-16.8
mV,
an
EE
94.73%.
formulation
exhibited
sustained
over
24
hours,
reaching
82.09%
cumulative
release.
Stability
indicated
minimal
changes
key
parameters
three
months
at
room
temperature.
Conclusions:
developed
liposomal
demonstrates
promising
characteristics
delivery,
potentially
enhancing
its
efficacy
DR.
Molecules,
Journal Year:
2025,
Volume and Issue:
30(3), P. 457 - 457
Published: Jan. 21, 2025
Ocular
diseases
affecting
the
anterior
and
posterior
segments
of
eye
are
major
causes
global
vision
impairment.
Curcumin,
a
natural
polyphenol,
exhibits
anti-inflammatory,
antioxidant,
antibacterial,
neuroprotective
properties,
making
it
promising
candidate
for
ocular
therapy.
However,
its
clinical
use
is
hindered
by
low
aqueous
solubility,
poor
bioavailability,
rapid
systemic
elimination.
This
review
comprehensively
highlights
advances
in
curcumin
delivery
systems
aimed
at
overcoming
these
challenges.
Emerging
platforms,
including
proniosomal
gels,
transferosomes,
cyclodextrin
complexes,
have
improved
permeability,
retention.
Nanoparticle-based
carriers,
such
as
hybrid
hydrogels
biodegradable
nanoparticles,
enable
sustained
release
targeted
delivery,
supporting
treatments
segment
like
diabetic
retinopathy
age-related
macular
degeneration.
For
conditions,
keratitis
dry
syndrome,
cyclodextrin-based
complexes
mucoadhesive
enhance
corneal
permeability
drug
Mechanistically,
modulates
key
pathways,
NF-κB
TLR4,
reducing
oxidative
stress,
angiogenesis,
apoptosis.
strategies
photodynamic
therapy
approaches
broaden
their
application
to
eyelid
conditions
neuroinflammatory
diseases.
These
advancements
address
curcumin’s
pharmacokinetic
limitations,
translation
into
ophthalmic
therapies.
work
underscores
potential
disease
management
advocates
trials
validate
safety,
efficacy,
therapeutic
relevance.
Pharmaceutical Development and Technology,
Journal Year:
2025,
Volume and Issue:
unknown, P. 1 - 26
Published: March 7, 2025
Transnovasomes
is
a
new
and
exciting
class
of
lipid-based
nanovesicles.
Colchicine
(COL)
hydrophilic
natural
alkaloid
with
anti-inflammatory
anti-mitotic
features
having
oral
administration
permeation
defects.
Recurrent
Aphthous
Ulcer
(RAU)
the
most
prevalent
disease
mucosa
suffering
from
lack
particular
final
preventative
therapy.
So,
designing
prolonged
effective
specialized
delivery
system
for
ulcer
treatment
important.
transnovasomes
(COL-TNs)
were
prepared
using
surfactants
(Span
60
&
Span
80),
free
fatty
acids
(Oleic
acid
Stearic
acid),
Cholesterol
Brij
58.
The
COL-TNs
evaluated
their
vesicle
size
(VS),
polydispersity
index
(PDI),
zeta
potential
(ZP),
entrapment
efficiency
(EE%),
ex-vivo
after
12
hours
(Q12h).
Values
VS,
PDI,
ZP,
EE%
Q12h
optimized
formulation
256.74
±
11.2
nm,
0.322
0.08,
-43.3
0.62,
85.35
3.7%
72.69
5.84%
respectively.
Drug
accumulation
was
ninefold
greater
than
drug
solution
8
hours.
In-vivo,
formulation,
alone
or
in
combination
platelet-rich
plasma
(PRP),
achieved
complete
healing
acetic-acid
induced
RAU
restoring
normal
levels
assayed
biomarkers
(TNF-
α,
NF-κβ,
IL-6,
MMP9,
VEGF)
histological
mucosa.
In
conclusion,
can
be
used
as
promising,
safe,
efficient
RAU,
monotherapy
therapy
PRP.
Drug Delivery,
Journal Year:
2025,
Volume and Issue:
32(1)
Published: April 7, 2025
Age-related
macular
degeneration
is
a
degenerative
eye
condition
that
affects
the
macula
and
results
in
central
vision
loss.
Phytoconstituents
show
great
promise
treatment
of
AMD.
AMD
therapy
can
benefit
from
advantages
phytoconstituents
loaded
nanofibers.
There
are
opportunities
to
improve
effectiveness
age-related
(AMD)
through
use
nanofiber-based
delivery
methods.
These
novel
platforms
encapsulate
distribute
plant-derived
bioactives
by
making
special
qualities
include
their
high
surface
area-to-volume
ratio,
variable
porosity,
biocompatibility.
Exploring
methods
provide
choice
for
enhancing
patient
adherence,
safety,
efficacy
managing
this
condition.
This
article
explores
potential
revolutionize
treatment,
providing
an
innovative
effective
approach
treat
Journal of drug targeting,
Journal Year:
2025,
Volume and Issue:
unknown, P. 1 - 36
Published: Feb. 18, 2025
Breast
cancer
remains
one
of
the
significant
health
issues
across
globe,
being
diagnosed
in
millions
women
worldwide
annually.
Conventional
therapeutic
options
have
substantial
adverse
effects
due
to
their
non-specificity
and
limited
drug
bioavailability.
Niosomes,
novel
delivery
systems
formed
from
non-ionic
surfactants,
with
or
without
cholesterol
charge-inducing
agents,
are
used
as
treating
BC.
Their
formulation
by
various
methods
enhances
efficacy
bioavailability
minimizes
side
effects.
Niosomal
tamoxifen
exhibits
target
enhanced
stability,
whereas
docetaxel
methotrexate
show
sustained
controlled
release,
respectively.5-Fluorouracil,
doxorubicin,
paclitaxel,
cyclophosphamide,
epirubicin
improved
cytotoxic
against
BC
when
combined
other
agents.
Furthermore,
repurposed
niosomal
formulations
anti-cancer
drugs
penetration,
reduced
tumor
volume,
significantly
anti-tumor
effect.
This
review
article
focuses
on
composition
niosomes
application
treatment
then
examines
how
could
contribute
research.
Pharmaceutical Development and Technology,
Journal Year:
2025,
Volume and Issue:
unknown, P. 1 - 20
Published: May 6, 2025
Transfersomes
(TFS)
are
deformable
vesicles,
known
for
their
ability
to
enhance
transdermal
drug
penetration.
This
study
aimed
develop
and
optimize
TFS
evaluate
whether
they
can
also
ocular
delivery
of
tonabersat,
a
poorly
soluble
inflammasome
inhibitor.
were
prepared
using
Phospholipon®
90G
with
Tween®
80
as
the
edge
activator.
The
effect
formulation
parameters
(edge
activator
cryoprotectant
concentrations)
on
characteristics
evaluated
full
factorial
experimental
design.
optimized
eyedrop
was
further
characterized
particle
size,
zeta
potential,
deformability,
entrapment
efficiency
(EE),
content,
pH,
osmolarity.
Further,
stability
over
3
months
at
different
storage
conditions.
Finally,
penetration
into
cornea,
conjunctiva,
eyelid
sclera-choroid
after
topical
application
studied
ex
vivo
tonabersat
solution
in
medium
chain
triglycerides
control.
formed
spherical
unilamellar
vesicles
mean
diameter
less
than
130
nm,
EE
greater
80%
stable
-20
°C
5
±
up
months.
resulted
significantly
control
without
affecting
barrier
properties
tested
tissue.
Drug
between
tissues
compared,
shedding
light
mechanism
eye.
Overall,
this
demonstrates
that
provide
promising
alternative
tonabersat.
The
novel
drug
delivery
system
‘spanlastics’
has
received
prominence
for
its
potential
to
enhance
stability,
targeted
delivery,
and
bioavailability.
Unlike
traditional
carriers,
these
surfactant-based
nanovesicles
have
nonionic
surfactants
(Spans)
incorporated
with
edge
activators,
giving
them
high
permeability
deformability.
Moreover,
spanlastic
formulations
overcome
some
of
the
most
important
limitations
systems,
offering
higher
chemical
stability
biocompatibility.
Their
ability
encapsulate
hydrophilic
lipophilic
drugs
increases
spanlastics'
use
various
administration
routes
like
oral,
ocular,
transdermal,
nasal
delivery.
Furthermore,
spanlastics
enable
controlled
sustained
release,
decreasing
frequency
dosage
improving
patient
compliance.
This
review
comprehensively
analyzes
technology
covering
composition,
preparation
methods,
mechanisms
penetration,
characterization,
as
well
major
pharmaceutical
applications,
highlighting
technology's
prospects
in
contemporary
nanomedicine.
