ChemistrySelect,
Journal Year:
2024,
Volume and Issue:
9(40)
Published: Oct. 23, 2024
Abstract
Transforming
growth
factor
β1
(TGF‐β)
is
a
cytokine
with
pleiotropic
biological
functions.
Recently,
its
signaling
pathway
has
been
highlighted
for
implicative
paradoxical
roles
in
prostate
cancer
(PCa).
Suppressing
downstream
effects
of
this
by
interfering
receptor
complex
formation
through
inhibition
the
TGF‐β1
leads
to
antitumor
effects,
illuminating
as
viable
therapeutic
target
PCa.
Our
compound
library—established
literature‐based
approach
that
identified
phytochemicals
published
evidence
against
TGF‐β1—was
screened
employing
molecular
docking,
density
functional
theory
(DFT),
and
dynamic
(MD)
simulations
identify
inhibitors.
Eight
24
docked
from
our
library
had
good
binding
affinity
(ranging
−11.7
−10
kcal/mol)
(PDB:
1PY5).
The
displayed
stability
reactivity
revealed
DFT
analysis
desirable
pharmacokinetic
profile.
top
four
phytochemical
complexes
high
energies
maintained
throughout
100
ns
simulation.
Qualitative
studies
on
drug
repurposing
attributes
bisindolylmaleimide,
flavopiridol,
baicalin,
gefitinib
inhibitors
are
recommended;
most
importantly,
suggest
further
wet‐lab
corroborate
these
phytochemicals—SB
202190,
SB
203580,
silymarin,
cryptotanshinone—in
targeted
development.
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(17), P. 9302 - 9302
Published: Aug. 27, 2024
Insulin-like
Growth
Factor-1
(IGF-1)
is
a
crucial
mitogenic
factor
with
important
functions
in
the
mammary
gland,
mainly
through
its
interaction
IGF-1
receptor
(IGF-1R).
This
activates
complex
signaling
network
that
promotes
cell
proliferation,
epithelial
to
mesenchymal
transition
(EMT)
and
inhibits
apoptosis.
Despite
extensive
research,
precise
molecular
pathways
intracellular
mechanisms
activated
by
IGF-1,
cancer,
remain
poorly
understood.
Recent
evidence
highlights
essential
roles
of
isoforms
breast
cancer
(BC)
development,
progression,
metastasis.
The
peptides
define
isoforms—IGF-1Ea,
IGF-1Eb,
IGF-1Ec—act
as
key
points
convergence
for
various
influence
growth,
metastasis
survival
BC
cells.
aim
this
review
provide
detailed
exami-nation
role
mature
biology
their
potential
use
possible
therapeutical
targets.
iScience,
Journal Year:
2025,
Volume and Issue:
28(2), P. 111827 - 111827
Published: Jan. 18, 2025
In
colorectal
cancer
(CRC),
increased
numbers
of
tumor-infiltrating
CD4+
regulatory
T
(Treg)
cells
correlate
with
tumor
development,
immunotherapy
failure,
and
poor
prognosis.
To
assess
how
CRC
tumors
directly
modulate
Treg
cell
differentiation,
we
developed
an
in
vitro
co-culture
system
using
from
Foxp3eGFP
mice
tumor-derived
organoids.
Co-culture
resulted
a
significant
increase
numbers.
RNA-sequencing
identified
distinct
transcriptional
profile
organoid-induced
cells,
upregulation
genes
associated
vivo.
High
expression
upregulated
correlates
shorter
progression-free
intervals
overall
survival
patients.
Human
organoids
similarly
induced
enhanced
suppressive
capacity
linked
to
This
model
provides
insights
into
differentiation
can
identify
approaches
disrupt
stimulate
anti-tumor
immunity.
Viruses,
Journal Year:
2025,
Volume and Issue:
17(2), P. 221 - 221
Published: Feb. 3, 2025
The
number
of
new
cancer
cases
is
soaring,
and
currently,
there
are
440.5
per
100,000
reported
every
year.
A
quarter
these
related
to
human
papillomavirus
(HPV)
infections,
particularly
types
16
18.
These
include
oropharyngeal,
anal,
vaginal,
penile
cancers.
critical
aspect
their
oncogenic
potential
lies
in
ability
manipulate
host
immune
responses,
facilitating
evasion
carcinogenesis.
High-risk
HPVs
target
key
components
like
granzymes
B
MHC-I,
which
crucial
for
the
elimination
virus-infected
transformed
cells,
thereby
weakening
surveillance.
Evidence
suggests
that
high-risk
downregulate
expression
tumor
suppressors,
such
as
p53
pRB,
activity
components,
CTL
NK
cell
thus
enabling
persistent
infection
We
discuss
implications
granzyme
MHC-I
dysregulation
evasion,
progression,
therapeutic
strategies.
This
review
further
explores
regulation
A,
B,
by
HPVs,
focusing
on
how
viral
oncoproteins,
E6
E7,
interfere
with
granzyme-mediated
cytotoxicity
antigen
presentation.
complex
interplay
between
may
provide
insights
into
novel
approaches
targeting
HPV-associated
International Journal of Molecular Sciences,
Journal Year:
2025,
Volume and Issue:
26(6), P. 2763 - 2763
Published: March 19, 2025
Glioblastomas
(GBMs),
among
the
most
aggressive
and
resilient
brain
tumors,
characteristically
exhibit
high
angiogenic
potential,
leading
to
formation
of
a
dense
yet
aberrant
vasculature,
both
morphologically
functionally.
With
these
premises,
numerous
expectations
were
initially
placed
on
anti-angiogenic
therapies,
soon
dashed
by
their
limited
efficacy
in
concretely
improving
patient
outcomes.
Neovascularization
GBM
emerged
as
complex,
dynamic,
heterogeneous
process,
hard
manage
with
classical
standard
care.
Growing
evidence
has
revealed
existence
non-canonical
strategies
angiogenesis,
variously
exploited
meet
its
ever-increasing
metabolic
demand
differently
involved
tumor
progression,
recurrence,
escape
from
treatments.
In
this
review,
we
provide
an
accurate
description
each
neovascularization
mode
encountered
tumors
date,
highlighting
molecular
players
signaling
cascades
primarily
involved.
We
also
detail
key
architectural
functional
aspects
characteristic
vascular
compartment
because
intricate
crosstalk
between
different
networks.
Additionally,
explore
repertoire
emerging
therapies
against
that
are
currently
under
study,
concluding
question:
faced
such
challenging
scenario,
could
combined
tailored
patient’s
genetic
signatures,
represent
effective
game
changer?
Pharmaceuticals,
Journal Year:
2025,
Volume and Issue:
18(4), P. 507 - 507
Published: March 31, 2025
Hepatic
stellate
cells
(HSC)
are
the
major
source
of
myofibroblasts
(MFB)
in
fibrosis
and
cancer-
associated
fibroblasts
(CAF)
both
primary
metastatic
liver
cancer.
Over
past
few
decades,
there
has
been
significant
progress
understanding
cellular
molecular
mechanisms
by
which
HCC
occur,
as
well
key
roles
HSC
their
pathogenesis.
HSC-targeted
approaches
using
specific
surface
markers
receptors
may
enable
selective
delivery
drugs,
oligonucleotides,
therapeutic
peptides
that
exert
optimized
anti-fibrotic
anti-HCC
effects.
Recent
advances
omics,
particularly
single-cell
sequencing
spatial
transcriptomics,
hold
promise
for
identifying
new
targets
diagnosing
treating
fibrosis/cirrhosis
