Role of enzyme replacement therapy for exocrine and nutritional insufficiency in patients with malignancies: A review DOI Open Access
I. E. Khatkov, И. В. Маев, Д.С. Бордин

et al.

Journal of Modern Oncology, Journal Year: 2024, Volume and Issue: 26(3), P. 380 - 389

Published: Nov. 11, 2024

Exocrine pancreatic insufficiency (EPI) is a condition in which the amount of secreted enzymes insufficient to maintain normal digestion. EPI frequent complication or other malignancies. The presence cancer patient may be suggested by symptoms maldigestion, malabsorption, and alteration nutritional markers; however, it important note that subtle. In early stages, latent manifested malnutrition. However, even later similar those masked after chemoradiation therapy. Antitumor therapy itself also cause EPI. Enzyme replacement (ERT) standard care for EPI, but rarely prescribed patients. supportive plays an essential role treating patients because quality life expectancy largely depend on adequacy complex treatment. review discusses possible causes its diagnosis treatment Special attention paid ERT regimens, including improving digestion drug's dosage form. It shown pancreatin minimicrospheres drug choice ERT, since minimum particle size facilitates most physiological process.

Language: Английский

Microbiome Integrity Enhances the Efficacy and Safety of Anticancer Drug DOI Creative Commons
Alice Njolke Mafe, Dietrich Büsselberg

Biomedicines, Journal Year: 2025, Volume and Issue: 13(2), P. 422 - 422

Published: Feb. 10, 2025

The intricate relationship between anticancer drugs and the gut microbiome influences cancer treatment outcomes. This review paper focuses on role of integrity in enhancing efficacy safety drug therapy, emphasizing pharmacokinetic interactions microbiota. It explores how disruptions to composition, or dysbiosis, can alter metabolism, immune responses, side effects. By examining mechanisms disruption caused by drugs, this highlights specific case studies like cyclophosphamide, 5-fluorouracil, irinotecan, their impact microbial diversity clinical also discusses microbiome-targeted strategies, including prebiotics, probiotics, postbiotics, fecal microbiota transplantation (FMT), as promising interventions enhance treatment. Furthermore, potential profiling personalizing therapy integrating these into practice is explored. Finally, proposes future research directions, developing novel biomarkers a deeper comprehension drug-microbiome interactions, respond current gaps knowledge improve patient outcomes care.

Language: Английский

Citations

4
Microbiota and Cytokine Modulation: Innovations in Enhancing Anticancer Immunity and Personalized Cancer Therapies DOI Creative Commons

Hamidreza Farhadi Rad,

Hamed Tahmasebi,

Samaneh Javani

et al.

Biomedicines, Journal Year: 2024, Volume and Issue: 12(12), P. 2776 - 2776

Published: Dec. 6, 2024

The gut microbiota plays a crucial role in modulating anticancer immunity, significantly impacting the effectiveness of various cancer therapies, including immunotherapy, chemotherapy, and radiotherapy. Its impact on development is complex; certain bacteria, like

Language: Английский

Citations

4
Unveiling the Interplay Between the Human Microbiome and Gastric Cancer: A Review of the Complex Relationships and Therapeutic Avenues DOI Open Access
Jenan Al‐Matouq,

Hawra Al-Ghafli,

Noura N. Alibrahim

et al.

Cancers, Journal Year: 2025, Volume and Issue: 17(2), P. 226 - 226

Published: Jan. 12, 2025

The human microbiota plays a crucial role in maintaining overall health and well-being. gut has been implicated developing progressing various diseases, including cancer. This review highlights the related mechanisms compositions that influence cancer pathogenesis with highlight on gastric We provide comprehensive overview of by which microbiome influences development, progression, response to treatment, focus identifying potential biomarkers for early detection, prevention strategies, novel therapeutic interventions leverage modulation. can guide future research clinical practices understanding harnessing optimize therapies.

Language: Английский

Citations

0
Influence of gut microbiota on systemic immune responses and cancer immunotherapy DOI

Swathi P. Murakonda,

Sriram Balusu,

Haritha Chava

et al.

International review of cell and molecular biology, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Language: Английский

Citations

0
Exploring the role of oral bacteria in oral cancer: a narrative review DOI Creative Commons

Hassan Mivehchi,

Aisan Eskandari-Yaghbastlo,

Parnian Pour Bahrami

et al.

Discover Oncology, Journal Year: 2025, Volume and Issue: 16(1)

Published: Feb. 26, 2025

A growing body of research indicates that a wide range cancer types may correlate with human microbiome components. On the other hand, little is known about potential contribution oral microbiota to cancer. However, some components can stimulate different tumorigenic processes associated development In this line, two prevalent infections, Porphyromonas gingivalis, and Fusobacterium nucleatum increase tumor growth. The impact course illness through direct interactions major modifications toxicity responsiveness kinds therapy. Recent has demonstrated relationship between specific phylogenetic groupings results immunotherapy treatment for particular types. Conversely, there been recent upsurge in interest possibility using microbes treat At moment, species, such as Salmonella typhimurium Clostridium spp., are being explored possible vectors. Thus, understanding these microbial highlights importance maintaining healthy preventing cancers. From perspective, review will discuss role on cancers their application treatment/improvement.

Language: Английский

Citations

0
Therapeutic potential of microbiome modulation in reproductive cancers DOI
Mega O. Oyovwi, Benneth Ben‐Azu,

Kehinde Henrietta Babawale

et al.

Medical Oncology, Journal Year: 2025, Volume and Issue: 42(5)

Published: April 6, 2025

Language: Английский

Citations

0
Safety and feasibility of laparoscopic stomach-partitioning gastrojejunostomy combined with neoadjuvant chemotherapy followed by minimally invasive gastrectomy for resectable gastric cancer with gastric outlet obstruction DOI

Tsuyoshi Tanaka,

Koichi Suda,

Masaya Nakauchi

et al.

Surgical Endoscopy, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 2, 2024

Language: Английский

Citations

1
Nanotherapeutics DOI
Abhiram Kumar,

Chhavi Dhiman,

Kumar Pranav Narayan

et al.

Advances in medical diagnosis, treatment, and care (AMDTC) book series, Journal Year: 2024, Volume and Issue: unknown, P. 177 - 204

Published: Dec. 17, 2024

The human gut microbiome played a major key role towards contributing essential functions to its host of an ecosystem. It refers the entire community microorganisms that colonize in specific locations including other microbes such as fungi, archaea, viruses, protozoans, and bacteria. scientific well understood healthy flora is majorly responsible for overall health host. This chapter aims explore innovative application nanotherapeutics addressing two critical challenges- dysbiosis cancer apoptosis. By leveraging nanotechnology, we delve into targeted drug delivery systems can selectively restore microbial balance induce apoptosis cells. Through comprehensive review current research advancements, this will highlight potential revolutionizing treatment strategies complex diseases at intersection microbiology oncology.

Language: Английский

Citations

1
Role of enzyme replacement therapy for exocrine and nutritional insufficiency in patients with malignancies: A review DOI Open Access
I. E. Khatkov, И. В. Маев, Д.С. Бордин

et al.

Journal of Modern Oncology, Journal Year: 2024, Volume and Issue: 26(3), P. 380 - 389

Published: Nov. 11, 2024

Exocrine pancreatic insufficiency (EPI) is a condition in which the amount of secreted enzymes insufficient to maintain normal digestion. EPI frequent complication or other malignancies. The presence cancer patient may be suggested by symptoms maldigestion, malabsorption, and alteration nutritional markers; however, it important note that subtle. In early stages, latent manifested malnutrition. However, even later similar those masked after chemoradiation therapy. Antitumor therapy itself also cause EPI. Enzyme replacement (ERT) standard care for EPI, but rarely prescribed patients. supportive plays an essential role treating patients because quality life expectancy largely depend on adequacy complex treatment. review discusses possible causes its diagnosis treatment Special attention paid ERT regimens, including improving digestion drug's dosage form. It shown pancreatin minimicrospheres drug choice ERT, since minimum particle size facilitates most physiological process.

Language: Английский

Citations

0