Microbiome Integrity Enhances the Efficacy and Safety of Anticancer Drug
Biomedicines,
Journal Year:
2025,
Volume and Issue:
13(2), P. 422 - 422
Published: Feb. 10, 2025
The
intricate
relationship
between
anticancer
drugs
and
the
gut
microbiome
influences
cancer
treatment
outcomes.
This
review
paper
focuses
on
role
of
integrity
in
enhancing
efficacy
safety
drug
therapy,
emphasizing
pharmacokinetic
interactions
microbiota.
It
explores
how
disruptions
to
composition,
or
dysbiosis,
can
alter
metabolism,
immune
responses,
side
effects.
By
examining
mechanisms
disruption
caused
by
drugs,
this
highlights
specific
case
studies
like
cyclophosphamide,
5-fluorouracil,
irinotecan,
their
impact
microbial
diversity
clinical
also
discusses
microbiome-targeted
strategies,
including
prebiotics,
probiotics,
postbiotics,
fecal
microbiota
transplantation
(FMT),
as
promising
interventions
enhance
treatment.
Furthermore,
potential
profiling
personalizing
therapy
integrating
these
into
practice
is
explored.
Finally,
proposes
future
research
directions,
developing
novel
biomarkers
a
deeper
comprehension
drug-microbiome
interactions,
respond
current
gaps
knowledge
improve
patient
outcomes
care.
Language: Английский
Unveiling the Interplay Between the Human Microbiome and Gastric Cancer: A Review of the Complex Relationships and Therapeutic Avenues
Cancers,
Journal Year:
2025,
Volume and Issue:
17(2), P. 226 - 226
Published: Jan. 12, 2025
The
human
microbiota
plays
a
crucial
role
in
maintaining
overall
health
and
well-being.
gut
has
been
implicated
developing
progressing
various
diseases,
including
cancer.
This
review
highlights
the
related
mechanisms
compositions
that
influence
cancer
pathogenesis
with
highlight
on
gastric
We
provide
comprehensive
overview
of
by
which
microbiome
influences
development,
progression,
response
to
treatment,
focus
identifying
potential
biomarkers
for
early
detection,
prevention
strategies,
novel
therapeutic
interventions
leverage
modulation.
can
guide
future
research
clinical
practices
understanding
harnessing
optimize
therapies.
Language: Английский
Influence of gut microbiota on systemic immune responses and cancer immunotherapy
Swathi P. Murakonda,
No information about this author
Sriram Balusu,
No information about this author
Haritha Chava
No information about this author
et al.
International review of cell and molecular biology,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 1, 2025
Language: Английский
Exploring the role of oral bacteria in oral cancer: a narrative review
Hassan Mivehchi,
No information about this author
Aisan Eskandari-Yaghbastlo,
No information about this author
Parnian Pour Bahrami
No information about this author
et al.
Discover Oncology,
Journal Year:
2025,
Volume and Issue:
16(1)
Published: Feb. 26, 2025
A
growing
body
of
research
indicates
that
a
wide
range
cancer
types
may
correlate
with
human
microbiome
components.
On
the
other
hand,
little
is
known
about
potential
contribution
oral
microbiota
to
cancer.
However,
some
components
can
stimulate
different
tumorigenic
processes
associated
development
In
this
line,
two
prevalent
infections,
Porphyromonas
gingivalis,
and
Fusobacterium
nucleatum
increase
tumor
growth.
The
impact
course
illness
through
direct
interactions
major
modifications
toxicity
responsiveness
kinds
therapy.
Recent
has
demonstrated
relationship
between
specific
phylogenetic
groupings
results
immunotherapy
treatment
for
particular
types.
Conversely,
there
been
recent
upsurge
in
interest
possibility
using
microbes
treat
At
moment,
species,
such
as
Salmonella
typhimurium
Clostridium
spp.,
are
being
explored
possible
vectors.
Thus,
understanding
these
microbial
highlights
importance
maintaining
healthy
preventing
cancers.
From
perspective,
review
will
discuss
role
on
cancers
their
application
treatment/improvement.
Language: Английский
Therapeutic potential of microbiome modulation in reproductive cancers
Medical Oncology,
Journal Year:
2025,
Volume and Issue:
42(5)
Published: April 6, 2025
Language: Английский
Microbiota and Cytokine Modulation: Innovations in Enhancing Anticancer Immunity and Personalized Cancer Therapies
Hamidreza Farhadi Rad,
No information about this author
Hamed Tahmasebi,
No information about this author
Samaneh Javani
No information about this author
et al.
Biomedicines,
Journal Year:
2024,
Volume and Issue:
12(12), P. 2776 - 2776
Published: Dec. 6, 2024
The
gut
microbiota
plays
a
crucial
role
in
modulating
anticancer
immunity,
significantly
impacting
the
effectiveness
of
various
cancer
therapies,
including
immunotherapy,
chemotherapy,
and
radiotherapy.
Its
impact
on
development
is
complex;
certain
bacteria,
like
Language: Английский
Safety and feasibility of laparoscopic stomach-partitioning gastrojejunostomy combined with neoadjuvant chemotherapy followed by minimally invasive gastrectomy for resectable gastric cancer with gastric outlet obstruction
Tsuyoshi Tanaka,
No information about this author
Koichi Suda,
No information about this author
Masaya Nakauchi
No information about this author
et al.
Surgical Endoscopy,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Dec. 2, 2024
Language: Английский
Nanotherapeutics
Advances in medical diagnosis, treatment, and care (AMDTC) book series,
Journal Year:
2024,
Volume and Issue:
unknown, P. 177 - 204
Published: Dec. 17, 2024
The
human
gut
microbiome
played
a
major
key
role
towards
contributing
essential
functions
to
its
host
of
an
ecosystem.
It
refers
the
entire
community
microorganisms
that
colonize
in
specific
locations
including
other
microbes
such
as
fungi,
archaea,
viruses,
protozoans,
and
bacteria.
scientific
well
understood
healthy
flora
is
majorly
responsible
for
overall
health
host.
This
chapter
aims
explore
innovative
application
nanotherapeutics
addressing
two
critical
challenges-
dysbiosis
cancer
apoptosis.
By
leveraging
nanotechnology,
we
delve
into
targeted
drug
delivery
systems
can
selectively
restore
microbial
balance
induce
apoptosis
cells.
Through
comprehensive
review
current
research
advancements,
this
will
highlight
potential
revolutionizing
treatment
strategies
complex
diseases
at
intersection
microbiology
oncology.
Language: Английский
Role of enzyme replacement therapy for exocrine and nutritional insufficiency in patients with malignancies: A review
Journal of Modern Oncology,
Journal Year:
2024,
Volume and Issue:
26(3), P. 380 - 389
Published: Nov. 11, 2024
Exocrine
pancreatic
insufficiency
(EPI)
is
a
condition
in
which
the
amount
of
secreted
enzymes
insufficient
to
maintain
normal
digestion.
EPI
frequent
complication
or
other
malignancies.
The
presence
cancer
patient
may
be
suggested
by
symptoms
maldigestion,
malabsorption,
and
alteration
nutritional
markers;
however,
it
important
note
that
subtle.
In
early
stages,
latent
manifested
malnutrition.
However,
even
later
similar
those
masked
after
chemoradiation
therapy.
Antitumor
therapy
itself
also
cause
EPI.
Enzyme
replacement
(ERT)
standard
care
for
EPI,
but
rarely
prescribed
patients.
supportive
plays
an
essential
role
treating
patients
because
quality
life
expectancy
largely
depend
on
adequacy
complex
treatment.
review
discusses
possible
causes
its
diagnosis
treatment
Special
attention
paid
ERT
regimens,
including
improving
digestion
drug's
dosage
form.
It
shown
pancreatin
minimicrospheres
drug
choice
ERT,
since
minimum
particle
size
facilitates
most
physiological
process.
Language: Английский