The Role of Elderberry Hydrolate as a Therapeutic Agent in Palliative Care

Antioxidants, Journal Year: 2025, Volume and Issue: 14(2), P. 233 - 233

Published: Feb. 18, 2025

Elderberry hydrolate, derived from the berries of Sambucus nigra, has gained attention for its therapeutic properties, particularly in skincare. This review explores potential applications palliative care, where patients often experience compromised skin health due to illness or treatment. The bioactive compounds elderberry including phenylacetaldehyde, 2-acetyl-pyrrole, n-hexanal, furfural, and (E)-beta-damascenone, contribute anti-inflammatory, antioxidant, antimicrobial, skin-healing effects. These properties make it a promising option addressing common dermatological issues such as irritation, dryness, pruritus, inflammation. For example, phenylacetaldehyde's antimicrobial anti-inflammatory actions help soothe irritated skin, while 2-acetyl-pyrrole's antioxidant effects protect sensitive oxidative stress. Additionally, n-hexanal's reduce infection risks furfural aids regeneration. (E)-beta-damascenone's maintain prevent further damage. Despite these effects, barriers widespread implementation hydrolate care exist, cost, accessibility, patient sensitivities, regulatory challenges. Future research focusing on standardized chemical profiling, clinical trials, practical concerns will be crucial integrating into regimens. highlights natural, supportive therapy enhancing comfort quality life settings.

Language: Английский

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Optimized Sambucus nigra L., Epilobium hirsutum L., and Lythrum salicaria L. Extracts: Biological Effects Supporting Their Potential in Wound Care

Antioxidants, Journal Year: 2025, Volume and Issue: 14(5), P. 521 - 521

Published: April 27, 2025

This study aimed to optimize the extraction of phytocompounds intended for wound care applications from three plant species, Sambucus nigra L. flowers and Epilobium hirsutum Lythrum salicaria aerial parts, by using a Quality Design approach. The effects different methods (ultra-turrax ultrasonic-assisted extraction), ethanol concentrations (30%, 50%, 70%), times (3, 5, 10 min) were studied, during optimization step, polyphenol flavonoid contents maximized. phytochemical profiles optimized HEs (herbal extracts) assessed LC-MS/MS methods. antioxidant capacity was determined DPPH (2,2-diphenyl-1-picrylhydrazyl radical scavenging capacity) TEAC (Trolox equivalent capacity), FRAP (ferric reducing power) assays, while antibacterial activity evaluated against Escherichia coli, Pseudomonas aeruginosa, MSSA—methicillin-sensitive Staphylococcus aureus MRSA—methicillin-resistant aureus). Cell viability healing potential on keratinocytes fibroblasts. anti-inflammatory effect fibroblasts measuring levels interleukins IL-6 IL-8 production nitric oxide RAW 264.7 cells. major compounds rutin chlorogenic acid. HE showed strongest activity, demonstrated high cell viability. increased capacities. All extracts displayed effects, exhibited best in vitro wound-healing effect.

Language: Английский

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Halochromic Bacterial Cellulose/Anthocyanins Hybrid Polymer Film with Wound-Healing Potential

Polymers, Journal Year: 2024, Volume and Issue: 16(16), P. 2327 - 2327

Published: Aug. 16, 2024

Polymer-based dressings deriving from natural biomaterials have advantages such as nontoxicity, biocompatibility, and mechanical stability, which are essential for efficient wound healing microbial infection diagnostics. Here, we designed a prototype of an intelligent hydrogel dressing on the base bacterial cellulose (BC) monitoring due to uploaded pH dye-sensor, anthocyanins (ANC) elderberry fruit (Sambucus nigra L.). The highest sensor responses metabolites ANC immobilized BC were observed at 5.0 6.0. detection limit signals was 3.45 A.U., it evaluated with smartphone-installed application. FTIR spectral analysis hybrid BC/ANC films has proved presence within matrix. Hybrid differed control ones by thicker microfibrils larger pores, detected scanning electron microscopy. Halochromic exhibited antimicrobial activities mainly against gram-positive bacteria yeast. They showed no cytotoxicity in vitro human cell lines mouse fibroblasts selected range anthocyanin concentrations released film/dressing prototype. Compared control, test overgrowth primary after applying 0.024-2.4 µg/mL ANC.

Language: Английский

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Hibiscus schizopetalus boosts wound healing via restoring redox balance and hindering inflammatory responses in rats: Insights on metabolome profiling and molecular docking

Archiv der Pharmazie, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 6, 2024

Abstract Hibiscus species (Malvaceae) possess a plethora of appealing pharmacological activities with an extended history customary use in diverse medical conditions. The present study aimed at comparing the metabolomic analyses three native to Egypt, namely H. tiliaceus , schizopetalus extract (HSE), and rosa‐sinensis alongside identifying promising natural wound healing candidate. Chemical profiling leaf extracts was achieved via UPLC‐ESI/MS/MS‐guided analysis that resulted tentative identification total 48 secondary metabolites pertaining phenolic acids, flavonoids, anthocyanins, fatty amides. Remarkably, vitro studies revealed HSE exhibited topmost activity. Subsequently, formulated into hydro‐ nanogel (1% w/v) formulations for further assessing its efficacy excision model. HSE‐nanogel demonstrated significant vivo contraction activity improving histopathological abnormalities. Mechanistically, upregulated antioxidant status through increasing levels reduced glutathione (GSH) catalase Moreover, suppressed inflammatory responses by diminishing expressions NF‐ĸB, TNF‐α, IL‐6. Molecular docking were performed on HSE's major constituents using CDOCKER, which supported findings. Collectively, exhibits notable aptitude as wound‐healing agent, warranting clinical appraisal.

Language: Английский

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Antidiabetic Potential of Black Elderberry Cultivars Flower Extracts: Phytochemical Profile and Enzyme Inhibition

Molecules, Journal Year: 2024, Volume and Issue: 29(23), P. 5775 - 5775

Published: Dec. 6, 2024

Black elderberry (

Language: Английский

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