Gabapentinoids related psychiatric disorders: an analysis based on the FAERS database from 2004 to 2023
Jingjing Li,
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Zhicheng Dai,
No information about this author
Zhengwei Zhang
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et al.
Expert Opinion on Drug Safety,
Journal Year:
2025,
Volume and Issue:
unknown, P. 1 - 9
Published: Jan. 3, 2025
Background
Gabapentinoids,
including
gabapentin
and
pregabalin,
are
commonly
used
for
neuropathic
pain
but
have
safety
concerns.
This
study
analyzed
U.S.
Food
Drug
Administration's
(FDA)
Adverse
Event
Reporting
System
(FAERS)
data
to
assess
risks
of
psychiatric
disorders
as
adverse
effects.
Language: Английский
Repurposing Antiepileptic Drugs for Cancer: A Promising Therapeutic Strategy
Noor Tarawneh,
No information about this author
S. A. Hussein,
No information about this author
Shtaywy Abdalla
No information about this author
et al.
Journal of Clinical Medicine,
Journal Year:
2025,
Volume and Issue:
14(8), P. 2673 - 2673
Published: April 14, 2025
Epilepsy
is
a
neurological
disorder
characterized
by
repeated
convulsions.
Antiepileptic
drugs
(AEDs)
are
the
main
course
of
therapy
for
epilepsy.
These
medications
given
according
to
each
patient’s
personal
medical
history
and
types
seizures
they
suffer.
They
have
been
employed
decades
manage
epilepsy,
thus
delivering
relief
from
through
numerous
mechanisms
action.
Aside
their
anticonvulsant
attributes,
current
evidence
suggests
that
certain
AEDs
may
display
potential
inhibitory
effects
against
cancer
invasion
metastasis.
This
review
explored
complicated
interactions
between
modes
action
pathways
causing
cancer,
impact
on
metastasis
various
forms
while
addressing
associated
side
effects.
For
example,
valproic
acid
inhibits
histone
deacetylase,
hyperacetylation
genes,
especially
those
regulating
cell
cycle,
culminating
in
cycle
arrest.
Topiramate
carbonic
anhydrase,
disrupting
acidic
microenvironment
needed
cells
thrive.
Lacosamide
increases
slow
inactivation
voltage
gated
Na+
channel,
inhibiting
growth,
proliferation,
many
cancers.
Although
drug
development
complex
task
due
regulatory,
intellectual
property,
economic
challenges,
researchers
exploring
repurposing
tactics
overcome
these
challenges
find
new
therapeutic
alternatives
diseases
like
cancer.
Thus,
considered
among
most
effective
ways
develop
candidates
using
novel
properties
characteristics,
this
also
discusses
issues.
Language: Английский
Formulation and characterization of cholesterol-based nanoparticles of gabapentin protecting from retinal injury
Frontiers in Chemistry,
Journal Year:
2024,
Volume and Issue:
12
Published: Oct. 21, 2024
Introduction
This
study
aimed
to
prepare
cholesterol
and
stearic
acid-based
solid
lipid
nanoparticles
of
gabapentin
(GAB-SLNs)
for
protection
against
streptozotocin
(STZ)-induced
retinal
injury
in
rats.
Methods
We
prepared
four
preparations
GAB-SLNs
using
a
hot
high-shear
homogenization
ultrasonication
process,
the
best
formulation
was
selected
tested
biological
activity.
The
brought
male
adult
albino
rats
while
doses
continued
6
weeks.
Six
groups
were
assigned
as
vehicle,
diabetic,
diabetic
+
(10–20
mg/kg),
mg/kg).
GAB-SLN#2
optimized
with
high
entrapment
efficacy
(EE%,
98.64%
±
1.97%),
small
particle
size
(185.65
2.41
nm),
negative
Zeta
potential
(−32.18
0.98
mV),
low
polydispersity
index
(0.28
0.02),
elevated
drug
release
(99.27%
3.48%).
TEM
image
revealed
smooth
surface
spherical
shape.
Results
provided
greater
than
free
indicated
by
histopathology
data
which
demonstrated
more
organization
layers
less
degeneration
ganglion
cell
layer
treated
GAB-SLN#2.
Further,
reduced
inflammatory
proteins
(IL-6/JAK2/STAT3)
vascular
endothelial
growth
factor
(VEGF).
Conclusion
preparation
enhanced
physical
properties
improved
its
activity
neuroprotectant.
Further
studies
are
warranted
validate
this
technique
use
oral
other
neurological
disorders.
Language: Английский
Gabapentin and loperamide co-administration effect on the neuropathic pain in alloxan diabetic female albino mice
Journal of Research in Pharmacy,
Journal Year:
2024,
Volume and Issue:
29(3), P. 1038 - 1044
Published: Aug. 7, 2024
The
present
study
aimed
to
evaluate
the
effect
of
gabapentin-loperamide
co-administration
on
induced
diabetic
neuropathic
pain
in
female
albino
mice.
involved
30
mice,
divided
into
six
groups:
Group
A
served
as
negative
group
and
received
distilled
water;
B
positive
(induced
pain);
for
14
days,
C
included
mice
that
solely
oral
gabapentin
(2.5
mg/kg);
D
2.5
mg/kg
days
orally
loperamide
0.05
orally.
E
includes
treated
with
1.8
orally,
F
1.2
(0.05
mg/kg)
Results
illustrated
showed
a
significant
decrease
levels
substance-p
interleukin-6
(10.92
±0.74
165.8
±8.53,
respectively)
comparison
those
(108.78
±4.46
1083.34
±76.35,
respectively),
which
may
be
attributed
increase
analgesic
due
reduction
its
elimination
from
body
by
decreasing
small
intestine
movement
increasing
absorption,
led
keeping
it
long
time.
Language: Английский