Traditional Chinese medicine combined with chemotherapy in the treatment of advanced non-small cell lung cancer: Key drug screening and mechanism analysis DOI
Qian Tang,

Xuefang Zheng,

Yu Tang

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: July 19, 2024

Abstract In the course of clinical treatment for anti-tumor, combination traditional Chinese medicine (TCM) and other schemes can reduce toxicity increase efficiency. The purpose this paper is to find out key TCM effective components non-small cell lung cancer (NSCLC) analyze its therapeutic mechanism by analyzing prescription combined with chemotherapy NSCLC. Firstly, prescriptions in randomized controlled trials NSCLC were collected, core was screened frequency statistics, association rule analysis cluster analysis. Then, intersection targets potential effects PPI enrichment performed on screen targets, pathways, verified molecular docking experiments. study, 269 among which medication Astragalus membranaceus (HQ, Chinese), Wolfiporia cocos (FL, Atractylodes macrocephala (BZ, Chinese) over 100. Association showed that they highly correlated clustered into same category Their Quercetin, Kaempferol Isorhamnetin. results AKT1 EGFR obtained network could bind stably. KEGG 110 pathways including PI3K-Akt; CCK-8 Isorhamnetin effectively inhibit proliferation A549 cells, had best inhibitory effect. migration invasion induce apoptosis, G1 phase arrest, decrease expression P-PI3K P-AKT cells. a word, include HQ, FL, BZ, etc. Kaempferol, have according research results.

Language: Английский

Natural polysaccharide-small molecule smart responsive nanogels: Design, synthesis, and synergistic chemoimmunotherapy for tumors DOI
Sibei Wang, Fan Nie, Zhen Lin

et al.

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 140930 - 140930

Published: Feb. 1, 2025

Language: Английский

Citations

1
Astragalus Polysaccharide Regulates Epithelial-mesenchymal Transition in HepG2 Liver Cancer Cells by Inhibiting NLRP3 Inflammasome Activation DOI Creative Commons
Hongtao Sui, Xiangliang Yang, Zongyuan Huang

et al.

Pharmacognosy Magazine, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 13, 2025

Background Epithelial-mesenchymal transition (EMT) is crucial in liver cancer progression. Developing novel medicines to disrupt the progression of EMT might be a approach managing cancer. Purpose This study investigates protective role Astragalus polysaccharide (APS), bioactive compound derived from membranaceus, modulating HepG2 cells. Methods The effects APS on were evaluated by assessing cell viability, proliferation, invasion, migration, cycle, and apoptosis Furthermore, involvement NOD-like receptor protein 3 (NLRP3) inflammasome this process was explored. Results Results: treatment significantly inhibited migration cells while promoting cycle arrest apoptosis. Notably, reduced expression NLRP3 components, including NLRP3, apoptosis-associated speck-like protein, caspase-1, decreasing levels inflammatory cytokines. In addition, activator Nigericin dampened effect partially rescuing activity NLRP3. Specifically, promoted development exacerbated malignant transformation improved APS. Conclusion Our findings demonstrated function which inhibits activation protect results showed that targeting application appears viable tactic for preventing

Language: Английский

Citations

0
Mechanism of Qingjie Fuzheng Granules in inhibiting colitis associated colorectal cancer by regulating TLR4 and IL-4R mediated macrophage polarization DOI
Haiqin Liu,

Ruiming Yang,

Hangyan Zhong

et al.

Journal of Ethnopharmacology, Journal Year: 2025, Volume and Issue: unknown, P. 119511 - 119511

Published: Feb. 1, 2025

Language: Английский

Citations

0
Polysaccharides as therapeutic vehicles in pancreatic cancer DOI
Seema Kumari, Sujatha Peela,

Ganji Purnachandra Nagaraju

et al.

Drug Discovery Today, Journal Year: 2025, Volume and Issue: unknown, P. 104320 - 104320

Published: Feb. 1, 2025

Language: Английский

Citations

0
Evaluating the role of astragalus polysaccharide in modulating immune infiltration and enhancing prognostic biomarkers in pediatric acute myeloid leukemia DOI Creative Commons

Minhui He,

Xianhui Zhang,

Jihong Zhang

et al.

Frontiers in Pharmacology, Journal Year: 2025, Volume and Issue: 16

Published: April 7, 2025

Background Childhood acute myeloid leukemia (AML) constitutes a significant proportion of pediatric malignancies, with current treatment options remaining limited. This study aimed to investigate the role Astragalus polysaccharide (APS) in immune infiltration and prognosis AML. Methods Differentially expressed genes (DEGs) were identified from GEO database (dataset GSE2191), APS-related (APSRGs) obtained Swiss Target Prediction platform. DEGs |logFC| > 1 p < 0.05 intersected APSRGs identify differentially (APSRDEGs), visualized using Venn diagram. A protein-protein interaction (PPI) network analysis was conducted hub genes. Gene Ontology (GO) KEGG enrichment analyses performed determine biological processes (BP), cellular components (CC), molecular functions (MF), relevant pathways associated Correlation analysis, receiver operating characteristic (ROC) curve assess relationship between Results The GSE2191 dataset divided into AML (PAML) control groups. total 1,881 identified, which 20 APSRDEGs. PPI revealed that 13 APSRDEGs interconnected, nine identified: CASP3 , PTPRC ELANE HMOX1 CHUK FLT1 JAK3 CTSL AURKA . GO indicated these significantly key processes, components, functions, involved ROC expression levels differed PAML Immune demonstrated strong correlation several cells, showing strongest positive neutrophils. Conclusion related APS These findings suggest may affect AML, highlighting its potential as therapeutic modulator for disease.

Language: Английский

Citations

0
Astragalus polysaccharide alleviates benzene-induced DNA damage and hematopoietic toxicity by inhibiting oxidative stress DOI

Jinxiu Feng,

Xulei Zuo,

Xingxing Gao

et al.

Food Bioscience, Journal Year: 2025, Volume and Issue: unknown, P. 106593 - 106593

Published: April 1, 2025

Language: Английский

Citations

0
The Potential of Plant Polysaccharides and Chemotherapeutic Drug Combinations in the Suppression of Breast Cancer DOI Open Access
Omowumi Oyeronke Adewale, Patrycja Wińska, Adrianna Maria Piasek

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(22), P. 12202 - 12202

Published: Nov. 13, 2024

Breast cancer is the most common affecting women worldwide. The associated morbidity and mortality have been on increase while available therapies for its treatment not totally effective. treatment, chemotherapy, sometimes has dangerous side effects because of non-specific targeting, in addition to poor therapeutic indices, high dose requirements. Consequently, agents with anticancer are being sought that can reduce induced by chemotherapy increasing cytotoxicity cells. This possible using natural compounds safe biologically active. There many reports plant polysaccharides due their bioactive properties. use polysaccharide together a conventional cytotoxic drug may offer wide benefits therapy, producing synergistic effects, thereby reducing and, so, effects. In this review, we highlight an overview chemotherapeutic drugs breast preclinical studies, including mechanisms activities. findings emphasize potential improve outcomes cancer, paving way more effective safer strategies.

Language: Английский

Citations

3
Arabinogalacturonan in functional food “Astragalus membranaceus root”: Structure and immunomodulatory activity DOI

Zhili Sheng,

Hui Liu,

Bailin Li

et al.

Food Hydrocolloids, Journal Year: 2024, Volume and Issue: 159, P. 110725 - 110725

Published: Oct. 10, 2024

Language: Английский

Citations

1
Phytochemical and Biological Investigations of Crude Extracts of Astragalus pisidicus DOI Creative Commons
Esra Aydemir, Elif Odabaş Köse, Serap Özkaya Gül

et al.

Pharmaceuticals, Journal Year: 2024, Volume and Issue: 18(1), P. 10 - 10

Published: Dec. 25, 2024

Background/Objectives: Astragalus L. is a genus of the Fabaceae family, encompassing over 3000 species globally, with 380 found in Turkey. This inaugural examination phytochemical, antioxidant, antibacterial, and cytotoxic properties pisidicus. Methods: The water methanolic fractions four parts (stems, flowers, leaves, root) as well whole plant were quantified identified by Liquid Chromatography Electrospray Ionization Tandem Mass Spectrometry (LC-ESI-MS/MS) analysis. Cell death was assessed using WST-1 assay, while apoptosis colorimetric protease assay for caspase 2, -3, -6, -8, -9, cellular DNA fragmentation assay. Antioxidant activity A. pisidicus extracts investigated eight different assays. Antimicrobial activities evaluated against 16 bacterial strains disc diffusion broth microdilution methods. Results: A total 13 phytochemicals detected at various concentrations. Hesperidin (147-40,174 µg/g extract) hyperoside (363-2677 comprised principal constituents among extracts. Fm (IC50 = 9.57 µg/mL), Rm 14.89 Sm µg/mL) active crude on H1299, HT-29, Panc-1 cells, 32.057 64.25 moderately MCF-7 22RV1 respectively. elevation 3, 6, 8, 9 enzyme activities, along fragmentation, signifies that mode cell apoptosis. According to test results, Fm, Lm, Sm, WPm exhibited antimicrobial gram (+) bacteria. Conclusions: elicited apoptotic cancer cells selectively activation caspases subsequent may serve novel source an apoptosis-inducing anticancer drug.

Language: Английский

Citations

1
Traditional Chinese medicine combined with chemotherapy in the treatment of advanced non-small cell lung cancer: Key drug screening and mechanism analysis DOI
Qian Tang,

Xuefang Zheng,

Yu Tang

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: July 19, 2024

Abstract In the course of clinical treatment for anti-tumor, combination traditional Chinese medicine (TCM) and other schemes can reduce toxicity increase efficiency. The purpose this paper is to find out key TCM effective components non-small cell lung cancer (NSCLC) analyze its therapeutic mechanism by analyzing prescription combined with chemotherapy NSCLC. Firstly, prescriptions in randomized controlled trials NSCLC were collected, core was screened frequency statistics, association rule analysis cluster analysis. Then, intersection targets potential effects PPI enrichment performed on screen targets, pathways, verified molecular docking experiments. study, 269 among which medication Astragalus membranaceus (HQ, Chinese), Wolfiporia cocos (FL, Atractylodes macrocephala (BZ, Chinese) over 100. Association showed that they highly correlated clustered into same category Their Quercetin, Kaempferol Isorhamnetin. results AKT1 EGFR obtained network could bind stably. KEGG 110 pathways including PI3K-Akt; CCK-8 Isorhamnetin effectively inhibit proliferation A549 cells, had best inhibitory effect. migration invasion induce apoptosis, G1 phase arrest, decrease expression P-PI3K P-AKT cells. a word, include HQ, FL, BZ, etc. Kaempferol, have according research results.

Language: Английский

Citations

0