Cells,
Journal Year:
2024,
Volume and Issue:
13(24), P. 2139 - 2139
Published: Dec. 23, 2024
Laser-induced
photothermal
therapy
using
gold
nanoparticles
(AuNPs)
has
emerged
as
a
promising
approach
to
cancer
therapy.
However,
optimizing
various
laser
parameters
is
critical
for
enhancing
the
conversion
efficacy
of
plasmonic
nanomaterials.
In
this
regard,
present
study
investigates
effects
dodecanethiol-stabilized
hydrophobic
ultrasmall
spherical
AuNPs
(TEM
size
2.2
±
1.1
nm),
induced
by
343
nm
wavelength
ultrafast
femtosecond-pulse
with
low
intensity
(0.1
W/cm2)
5
and
10
min,
on
cell
morphology
viability
human
hepatocellular
carcinoma
(HepG2)
cells
treated
in
vitro.
The
optical
microscopy
images
showed
considerable
alteration
overall
irradiated
light.
Infrared
thermometer
measurements
that
temperature
medium
exposed
increased
steadily
from
22
°C
46
48.5
after
respectively.
WST-1
assay
results
significant
reduction
viability,
demonstrating
synergistic
therapeutic
effect
femtosecond
HepG2
cells.
obtained
pave
way
design
less
expensive,
effective,
minimally
invasive
treat
cancers
reduced
side
effects.
Polymers,
Journal Year:
2025,
Volume and Issue:
17(7), P. 833 - 833
Published: March 21, 2025
Polymeric
nanoparticles
(PNPs)
represent
a
groundbreaking
advancement
in
targeted
drug
delivery,
offering
significant
benefits
over
conventional
systems.
This
includes
their
versatility,
biocompatibility,
and
ability
to
encapsulate
diverse
therapeutic
agents
provide
controlled
release,
improving
efficacy
while
minimizing
side
effects.
The
polymers
used
PNP
formulations
are
critical,
as
they
influence
the
nanoparticles'
physicochemical
properties
such
size,
shape,
surface
charge,
drug-loading
capacity.
Recent
developments
polymer
chemistry
nanotechnology
have
led
creation
of
smart
PNPs
that
can
respond
specific
stimuli,
enabling
precise
release
environments.
review
explores
mechanisms
innovations
polymeric
formulations,
fabrication
characterization
techniques
enhance
delivery
Additionally,
it
discusses
challenges
future
directions
field,
highlighting
potential
for
personalized
medicine
role
artificial
intelligence
optimizing
nanoparticle
design.
By
examining
relationship
between
characteristics
performance,
aims
promote
innovative
strategies
modern
medicine.
Despite
promise
polymer-based
systems,
toxicity,
stability,
scalability,
regulatory
compliance
must
be
addressed.
Future
research
should
focus
on
rigorous
testing,
clear
risk
communication,
sustainable
practices
support
clinical
translation
commercial
viability.
Overall,
integration
these
elements
is
crucial
advancing
applications.
PeerJ,
Journal Year:
2025,
Volume and Issue:
13, P. e19332 - e19332
Published: April 24, 2025
Tumors
pose
a
serious
threat
to
global
public
health
and
are
usually
treated
from
two
aspects:
tumor
cells
microenvironment.
Compared
with
traditional
chemotherapy
drugs,
Chinese
medicine
(TCM)
monomers
have
advantages
in
treatment,
such
as
multiple
targets,
levels
synergistic
intervention.
However,
most
TCM
active
ingredients
disadvantages
poor
water
solubility
stability,
which
restrict
their
clinical
application.
Nano
drug
delivery
systems
the
functions
of
improving
bioavailability
anti-tumor
ingredients,
enhancing
tissue
targeting,
achieving
controlled
release,
inhibiting
multidrug
resistance.
free
monomers,
they
higher
therapeutic
effects
fewer
side
effects.
This
article
summarizes
five
commonly
used
monomer
nanocarriers,
including
lipid
nanomaterials,
exosomes,
polymer
micelles,
carbon
nanotubes,
dendrimers,
explains
mechanisms
after
combining
TCM,
cell
proliferation
metastasis,
regulating
microenvironment,
etc
.
At
same
time,
potential
nano
combined
radiotherapy
immunotherapy
is
discussed,
well
current
problems
toxicity,
long-term
complex
amplification
process,
future
development
directions,
aiming
provide
reference
for
promoting
application
ingredients.
Journal of the Egyptian National Cancer Institute,
Journal Year:
2024,
Volume and Issue:
36(1)
Published: Dec. 28, 2024
Abstract
Background
Green
synthesis
techniques
have
drawn
a
lot
of
interest
lately
since
they
are
beneficial
to
the
environment
and
potential
uses
in
variety
industries,
including
biomedicine.
Because
their
special
physicochemical
characteristics,
copper
nanoparticles
(CuNPs)
become
one
most
interesting
options
for
use
biological
applications
among
nanomaterials.
An
overview
green
methods
CuNPs
is
given
this
review,
along
with
discussion
cancer
therapeutics.
The
benefits
drawbacks
certain
techniques,
such
as
plant-mediated,
microorganism-mediated,
other
environmentally
friendly
processes,
discussed.
Moreover,
thorough
CuNPs’
uses,
antibacterial
activity,
anticancer
potential,
drug
transport,
bioimaging
capabilities.
Furthermore,
difficulties
prospects
application
green-synthesised
biomedicine
Advances in medical technologies and clinical practice book series,
Journal Year:
2024,
Volume and Issue:
unknown, P. 117 - 146
Published: Sept. 25, 2024
Cancer
is
a
pathological
condition
characterized
by
the
uncontrolled
growth
and
dissemination
of
certain
cells
inside
body.
Currently,
cancer
poses
significant
global
challenge.
The
marine
ecosystem
bountiful
reservoir
biologically
potent
compounds
that
carry
enormous
promise
for
treatment
various
ailments,
particularly
cancer.
anticancer
properties
natural
have
been
previously
demonstrated
in
both
laboratory
animal
investigations.
field
marine-based
pharmaceuticals
has
begun
to
an
influence
on
current
pharmacology.
Various
anti-cancer
therapies
are
developed
from
components
officially
approved
clinical
usage.
This
book
chapter
specifically
examines
bioactive
obtained
habitats
properties.
It
also
explores
therapeutic
applications
these
molecules
wide
range
innovative
sources
species
purposes.
Frontiers in Cell and Developmental Biology,
Journal Year:
2024,
Volume and Issue:
12
Published: Dec. 5, 2024
Tumor,
as
the
second
leading
cause
of
death
globally,
following
closely
behind
cardiovascular
diseases,
remains
a
significant
health
challenge
worldwide.
Despite
existence
various
cancer
treatment
methods,
their
efficacy
is
still
suboptimal,
necessitating
development
safer
and
more
efficient
strategies.
Additionally,
advancement
personalized
therapy
offers
further
possibilities
in
treatment.
Nanomedicine,
promising
interdisciplinary
field,
has
shown
tremendous
potential
prospects
diagnosis
cancer.
As
an
emerging
approach
oncology,
application
nanomedicine
primarily
focuses
on
targeted
drug
delivery
systems
such
passive
targeting
delivery,
active
environmentally
responsive
well
imaging
diagnostics
tumor
biomarker
detection,
cell
vivo
imaging.
However,
it
faces
challenges
regarding
safety,
biocompatibility,
other
issues.
This
review
aims
to
explore
advances
use
nanomaterials
field
investigate
developing
therapies
care,
providing
direction
for
clinical
translation
application.
Cells,
Journal Year:
2024,
Volume and Issue:
13(24), P. 2139 - 2139
Published: Dec. 23, 2024
Laser-induced
photothermal
therapy
using
gold
nanoparticles
(AuNPs)
has
emerged
as
a
promising
approach
to
cancer
therapy.
However,
optimizing
various
laser
parameters
is
critical
for
enhancing
the
conversion
efficacy
of
plasmonic
nanomaterials.
In
this
regard,
present
study
investigates
effects
dodecanethiol-stabilized
hydrophobic
ultrasmall
spherical
AuNPs
(TEM
size
2.2
±
1.1
nm),
induced
by
343
nm
wavelength
ultrafast
femtosecond-pulse
with
low
intensity
(0.1
W/cm2)
5
and
10
min,
on
cell
morphology
viability
human
hepatocellular
carcinoma
(HepG2)
cells
treated
in
vitro.
The
optical
microscopy
images
showed
considerable
alteration
overall
irradiated
light.
Infrared
thermometer
measurements
that
temperature
medium
exposed
increased
steadily
from
22
°C
46
48.5
after
respectively.
WST-1
assay
results
significant
reduction
viability,
demonstrating
synergistic
therapeutic
effect
femtosecond
HepG2
cells.
obtained
pave
way
design
less
expensive,
effective,
minimally
invasive
treat
cancers
reduced
side
effects.
