Inflammopharmacology, Journal Year: 2024, Volume and Issue: unknown
Published: Oct. 29, 2024
Language: Английский
Abdominal Radiology, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 3, 2025
Language: Английский
Citations
1
Biomedicines, Journal Year: 2025, Volume and Issue: 13(4), P. 775 - 775
Published: March 22, 2025
Immune-mediated inflammatory diseases (IMIDs) are characterized by chronic systemic inflammation and multi-organ involvement. Fibrosis formation in IMIDs can cause tissue destruction subsequently organ malfunction. Fibroblast activation protein inhibitor positron emission tomography/computed tomography (FAPi PET/CT) represents a novel imaging technique that holds great potential to visualize vivo fibrosis. We here provide an overview of available evidence on FAPi PET/CT fibrosis various IMIDs, including interstitial lung diseases, immunoglobulin G4-related cardiovascular kidney gastrointestinal diseases. demonstrates high sensitivity detecting early fibrosis, correlating with disease severity, across different showing superiority compared conventional modalities. Although might be useful tool assess formation, thereby aiding grading severity staging, future studies should include larger sample sizes broad variety emphasis the optimization protocols further validate its diagnostic value.
Language: Английский
Citations
0
Pharmaceuticals, Journal Year: 2025, Volume and Issue: 18(4), P. 522 - 522
Published: April 3, 2025
Fibroblast activation protein (FAP) is a serine protease selectively expressed in cancer-associated fibroblasts (CAFs), fibrotic tissues, and areas of active tissue remodeling, making it an attractive target for diagnostic imaging across spectrum disease. FAP inhibitors (FAPIs) labeled with PET tracers have rapidly advanced as novel modality broad clinical applications that offers several advantages, including rapid tumor accumulation, low background uptake, high tumor-to-background ratios. In oncology, FAPI has demonstrated excellent performance visualizing wide range malignancies, those glycolytic activity, such pancreatic cancer, cholangiocarcinoma, certain sarcomas. Its sensitivity specificity the stromal component enables improved delineation, staging, response assessment. Additionally, potential to guide theranostic approaches, where same tracer can be therapeutic radionuclides, positions key player precision oncology. Beyond shown promise conditions characterized by inflammatory processes. cardiovascular field, being investigated its ability detect myocardial fibrosis cardiac crucial like heart failure, post-myocardial infarction hypertrophic cardiomyopathy. This review highlights expanding FAPI-based inflammation, While current data are promising, further large-scale studies multicenter trials essential validate these findings establish standardized protocols. The versatility applicability underscore transformative tool medicine.
Language: Английский
Citations
0
Clinical Nuclear Medicine, Journal Year: 2025, Volume and Issue: unknown
Published: May 14, 2025
Fibroblast activation protein (FAP) is a type II transmembrane protease expressed in cancer-associated fibroblasts (CAF) that constitute part of the tumor stroma and influence microenvironment. Although FAP not expected to be physiologically noncancer-associated cells, it can observed wound healing, arthritis, atherosclerotic plaques, fibrosis. In this case, we would like present early-stage 68 Ga FAPI-46 PET/CT inflammation findings at trocar entry site mimicking Sister Mary Joseph’s nodule patient diagnosed with gastric signet ring cell carcinoma.
Language: Английский
Citations
0
Inflammopharmacology, Journal Year: 2024, Volume and Issue: unknown
Published: Oct. 29, 2024
Language: Английский
Citations
2