Antibacterial and Antitumoral Potentials of Phytosynthesized Silver/Silver Oxide Nanoparticles Using Tomato Flower Waste

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(18), P. 9871 - 9871

Published: Sept. 12, 2024

This study presents the phytosynthesis of silver-based nanoparticles using tomato flower waste extracts for first time in literature. The determination total polyphenolic and flavonoid contents showed high gallic acid equivalents (6436-8802 mg GAE/kg dm) quercetin (378-633 QE/kg dm), respectively, dependent on extraction method. By Ultra Performance Liquid Chromatography technique, 14 compounds were identified quantified extracts. abundant phenolic caffeic (36,902-32,217 mg/kg) chlorogenic (1640-1728 mg/kg), catechin (292-251 luteolin (246-108 mg/kg). Transmission electron microscopy revealed a particle size range 14-40 nm. Fourier Transform infrared spectroscopy X-ray diffraction studies confirmed silver/silver oxide nanoparticles. These findings hold significant results antibacterial antitumoral potential applications obtained nanoparticles, opening new areas research development inspiring further exploration. impact this field metallic nanoparticle is substantial, as it introduces novel approach could lead to advancements field.

Language: Английский

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Synthesis, Characterization, and Evaluation of the Antimicrobial and Anticancer Activities of Zinc Oxide and Aluminum-Doped Zinc Oxide Nanocomposites

Pharmaceuticals, Journal Year: 2024, Volume and Issue: 17(9), P. 1216 - 1216

Published: Sept. 16, 2024

In this research, we developed undoped and aluminum-doped zinc oxide for antimicrobial anticancer activities. This study focuses on the synthesis, characterization, biological activities of nanoparticles (ZnO NPs) nanocomposites (Zn1−xAlxO NCs) at varying concentrations (x = 0, 0.25, 0.5, 0.75 wt%) using coprecipitation method. Various characterization techniques such as XRD, UV-Vis, FTIR, EDX, SEM were performed to analyze crystal structure, optical properties, functional group identification, elemental composition, surface morphology. The activity test showed that Zn0.75Al0.25O NCs exhibited strongest inhibition zone against Bacillus cereus compared Staphylococcus aureus > Pasteurella multocida Escherichia coli. Moreover, cytotoxicity cell viability liver cancer (HepG-2), breast (MCF-7), ovarian (SKOV3), normal lines) evaluated MTT assay, demonstrating not only enhance destruction but also show low high biocompatibility concentrations. These results suggest could be a promising candidate in vivo applications should further investigated.

Language: Английский

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Synergistic response of PEG coated manganese dioxide nanoparticles conjugated with doxorubicin for breast cancer treatment and MRI application

Arabian Journal of Chemistry, Journal Year: 2024, Volume and Issue: 17(10), P. 105958 - 105958

Published: Aug. 20, 2024

In this research work, we designed a smart biodegradable PEG-coated MnO2 nanoparticles conjugated with doxorubicin (PMnO2-Dox NPs) for dual chemo-photodynamic therapy and magnetic resonance imaging (MRI) application. This highly sensitive pH-responsive PMnO2-Dox NPs causes effective drug release under acidic pH environment. not only improves the efficacy of due to synergistic response as well improved MRI via boosting T1 contrast. Manifold characterization techniques have been employed materials investigation. Crystallography were performed by using XRD analysis, which confirmed tetragonal crystal structure an approximate crystallite size 20–30 nm. Surface morphology was SEM results indicated spherical asymmetric agglomerated nanocluster NPs. in vitro bioassay, anticancer activity tested against breast cancer (MCF-7) cell line MTT test. Moreover, it can also inhibit growth primary secondary cancers without light exposure. Results suggested that convenient treatment combined but address way towards comprehensive strategy application bright contrast agent after overcoming problem multidrug resistance (MDR) therapeutic analysis.

Language: Английский

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Thermoluminescence response of Ce doped CaTiO₃ nanophosphor synthesized by hydrothermal method for gamma dosimetry

Radiochimica Acta, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 19, 2024

Abstract Nanocrystalline calcium titanate (CaTiO 3 ) doped with cerium ions (0.02 mol%) was synthesized via hydrothermal method and its luminescent properties were studied for gamma dosimetry. For the samples, best response achieved after annealing at 700 °C 8 h. The synthesis confirmed XRD technique yielding cyrstallite size of 22 nm most intense peak (121). surface morphology scanning electron microscopy (SEM) grain 12 µm. strong IR absorptions appeared cm−1 712 cm −1 attributed to bending mode vibrations changing angle between Ti–O–Ti CaTiO :Ce respectively, as Fourier-Transform Infrared (FTIR) Spectroscopy. Thermoluminescent (TL) undoped samples by Mikrolab RA94 TLD Reader-Analyzer having heating rate 10 °C/s, absorbed doses 0–20 mGy from 137 Cs γ-source a dose 100 mSv/h. found values 662 keV photon-sensing parameters, i.e., mass attenuation coefficients ( μ / ρ ), mass-energy coefficient en effective atomic number photon interaction Z eff,PI total energy absorption eff,PEA 0.07030882 2 /g, 0.0280245 13.9 13.4 respectively. Thus, nanophosphor has shown excellent thermoluminescent dosimetric radiation sensing in selected range.

Language: Английский

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Recent advances of mesoporous silica-based nanocomposites for photodynamic therapy: A review

Process Biochemistry, Journal Year: 2024, Volume and Issue: 148, P. 79 - 103

Published: Nov. 16, 2024

Language: Английский

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