Perioperative Care in Periampullary Tumours DOI
H.S. Raju,

Marcos Raúl,

Namitha Shaji

et al.

Indian Journal of Continuing Nursing Education, Journal Year: 2024, Volume and Issue: 25(2), P. 102 - 117

Published: July 1, 2024

The incidence of periampullary tumours has been on the rise in India. Although significant advances have made diagnostic and treatment modalities, they remain one which eludes early diagnosis owing to lack screening tests. This is compounded by a complex surgical procedure only modality with curative intent. Focussed perioperative care can effect improving positive patient outcomes. article outlines disease, options such as biliary drainage, surgery clinical guidelines period, would enable nurses provide competent comprehensive care.

Language: Английский

Systemic therapy with pemigatinib and sintilimab followed by resection for recurrent FGFR-2-positive intrahepatic cholangiocarcinoma: a case report DOI Creative Commons
Yuchen Yang, Jingfeng Li, Di Ma

et al.

Frontiers in Oncology, Journal Year: 2025, Volume and Issue: 15

Published: April 4, 2025

Background Fibroblast growth factor receptor-2 (FGFR-2) mutations are frequently observed in intrahepatic cholangiocarcinoma (ICC). While FGFR2-targeted therapies primarily studied advanced ICC, this report presents a rare case of locally recurrent ICC treated with systemic therapy, leading to significant tumor regression and successful R0 resection. Case presentation A 51-year-old female underwent right posterior hepatectomy cholecystectomy 2018 for ICC. In August 2022, postoperative MRI revealed recurrence near the hepatic vein, accompanied by bile duct dilation thrombus. Given tumor’s proximity critical structures confirmed FGFR-2 fusion, therapy pemigatinib sintilimab was initiated. After four cycles, showed partial remission, reduction May 2023, patient hemi-hepatectomy. Postoperatively, she continued combination without or metastasis 19 months. Conclusion This highlights efficacy pemigatinib-based achieving enabling curative resection FGFR-2-positive The outcome underscores potential targeted managing warranting further investigation.

Language: Английский

Citations

0
Focal Update on Immunotherapy and Liver Transplantation in the Era of Transplant Oncology DOI Creative Commons
Maen Abdelrahim, Abdullah Esmail, Taizo Hibi

et al.

Current Oncology, Journal Year: 2024, Volume and Issue: 31(9), P. 5021 - 5026

Published: Aug. 28, 2024

Transplant oncology is an expanding area of cancer therapy that specifically emphasizes the use liver transplantation (LT) as preferred treatment for patients with manageable, but unresectable, tumors. The management and optimization overall survival strategies, accompanied by arguably decent quality life, have been at forefront treatment, a plurality all primary cancers are identified either hepatocellular carcinoma (HCC) or cholangiocarcinoma (CCA), which classified highly aggressive malignancies frequently remain asymptomatic until they progress to advanced stages, rendering curative procedures, such resection, impractical. This has led increase in utilization neoadjuvant interventions conducted prior surgery, yielded favorable outcomes. Though this modality prompted further investigations into efficacy immune checkpoint inhibitors (ICPIs) standalone treatments combination locoregional (LRTs) bridge more eligibility. multidisciplinary methodology planning seen multiple successful trials immunotherapy regimes combinate treatments, setting groundwork increasing eligibility through downstaging "bridging" previously ineligible within stringent LT criteria. Surveillance after crucial component transplant oncology. emergence circulating tumor DNA (ctDNA) provided novel approach identifying recurrence its early stages. Recent research focused on liquid biopsy, technique effectively identifies dynamics cancer. another innovation demonstrate rate rapidly advancing, making focus care feel disorienting. Modalities constantly evolving, when field changing one, it imperative reorient data needs patients. In commentary, we reflect update's ICPIs settings well updates biopsy post-LT follow-up surveillance.

Language: Английский

Citations

1
Splicing, Signaling, and Survival: The Role of RBM39 in Cholangiocarcinoma Progression DOI Creative Commons

Meng Xu,

Diego F. Calvisi, Xin Chen

et al.

Cellular and Molecular Gastroenterology and Hepatology, Journal Year: 2024, Volume and Issue: unknown, P. 101419 - 101419

Published: Oct. 1, 2024

Language: Английский

Citations

0
Perioperative Care in Periampullary Tumours DOI
H.S. Raju,

Marcos Raúl,

Namitha Shaji

et al.

Indian Journal of Continuing Nursing Education, Journal Year: 2024, Volume and Issue: 25(2), P. 102 - 117

Published: July 1, 2024

The incidence of periampullary tumours has been on the rise in India. Although significant advances have made diagnostic and treatment modalities, they remain one which eludes early diagnosis owing to lack screening tests. This is compounded by a complex surgical procedure only modality with curative intent. Focussed perioperative care can effect improving positive patient outcomes. article outlines disease, options such as biliary drainage, surgery clinical guidelines period, would enable nurses provide competent comprehensive care.

Language: Английский

Citations

0