Preparation of bee venom-loaded chitosan nanoparticles for treatment of streptozotocin-induced diabetes in male Sprague Dawley rats

Beni-Suef University Journal of Basic and Applied Sciences, Journal Year: 2024, Volume and Issue: 13(1)

Published: Sept. 30, 2024

Abstract Background Diabetes mellitus (DM) can be defined as an increase in the blood sugar level and a disturbance protein, fat carbohydrate metabolism. Bee venom (BV) is useful for treating preventing diabetic rats’ histological biochemical problems. Although medical advantages of BV have been identified, its safety has remained substantial barrier application. Consequently, goal our work was to prepare bee venom-loaded chitosan (BV-CS) nanoparticles (NPs), which would then physically characterized. This followed by examining effect synthetized BV-CS NPs on oxidation, inflammation coagulation vitro. In model [induced streptozotocin (STZ)], produced were tested anti-diabetic medication. Results vivo testing pancreatic tissue homogenates showed that antioxidant anti-inflammatory properties. The results used safe efficient therapy diabetes. Up concentration 250 µg/ml, generated demonstrated potential antioxidant, membrane stabilizing, non-cytotoxic capabilities. Our findings indicated administration significantly controlled glucose levels metabolic abnormalities accompanied diabetes induction. Conclusions successful STZ-induced rats, stimulated insulin secretion vivo. Graphical abstract

Language: Английский

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Synthetic approaches, emerging applications, and challenges of indole-based five-membered heterocycles in medicinal chemistry

Deleted Journal, Journal Year: 2025, Volume and Issue: 7(3)

Published: March 7, 2025

Abstract Scientists are fascinated by the indole structure due to its diverse biological activities, encompassing both itself and numerous substituted derivatives. Heterocycles, particularly those containing indoles, play pivotal roles in domains of medicinal chemistry, drug designing discovery, agrochemicals, photochemistry, dyes, other applications, which has led their prominence chemistry field. This review highlights applications indole-based five-membered heterocycles as versatile scaffolds for development, emphasizing therapeutic potential antidiabetic, anti-inflammatory, anticancer, antimicrobial, antioxidant agents, antialzheimer anticonvulsant agents. A comprehensive literature search was carried out explore chemical, biological, structural activity correlations hybrids. Studies published between 2017 2024 were chosen from databases such PubMed, Scopus Google Scholar, synthesis, application chemistry. Unique this is exploration structure–activity relationships (SAR), synthetic approaches emerging challenges development drugs. Key insights include innovative strategies enhance efficacy through modifications various derivatives areas. These findings hold great improving design more effective pharmaceuticals. Graphical abstract

Language: Английский

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Enhancing Survival Following High-Risk Surgery by Modulating Actionable Items within the Pathobiome

IntechOpen eBooks, Journal Year: 2025, Volume and Issue: unknown

Published: May 15, 2025

Infection-related complications are common among surgical patients and result in morbidity mortality. Despite the use of antibiotics, infection-related continue to occur. While main sources postoperative infections have been assumed be due some types perioperative external contamination, an increasing number studies suggested endogenous source when intestinal pathogens disseminate cause syndrome “gut-origin sepsis.” In this context, composition function microbiome appear play a crucial role. Patients at increased risk for these shifts pathobiome becomes predominated by pathogenic organisms instead usual beneficial organisms. It is important note that may manifest its most aggressive form conditions such host experiences significant physiological stress (i.e., stress) which often involves long periods inanition, injury antibiotic exposure. review, pathobiomes will defined compared microbiomes incorporate mechanisms virulence activation opportunistic within emerge over course injury. We define physiologic context associated with as well suppression defense can occur abnormally functioning pathobiomes. Along line reasoning, there several possible strategies preventing improving microbiota suppressing thereby mitigating impact factors on pathogen expression.

Language: Английский

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Bisindole Compounds—Synthesis and Medicinal Properties

Antibiotics, Journal Year: 2024, Volume and Issue: 13(12), P. 1212 - 1212

Published: Dec. 13, 2024

The indole nucleus stands out as a pharmacophore, among other aromatic heterocyclic compounds with remarkable therapeutic properties, such benzimidazole, pyridine, quinoline, benzothiazole, and others. Moreover, series of recent studies refer to strategies for the synthesis bisindole derivatives, various medicinal antimicrobial, antiviral, anticancer, anti-Alzheimer, anti-inflammatory, antioxidant, antidiabetic, etc. Also, natural are mentioned in literature their biological properties starting point related bisindoles. Drawing from these data, we have proposed this review provide an overview techniques qualities bisindolic that been 2010 2024 well numerous uses chemistry materials, nanomaterials, dyes, polymers, corrosion inhibitors.

Language: Английский

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