Plasma and Visceral Organ Kynurenine Metabolites Correlate in the Multiple Sclerosis Cuprizone Animal Model DOI Open Access
Helga Polyák, Zsolt Galla, Cecília Rajda

et al.

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(3), P. 976 - 976

Published: Jan. 24, 2025

The cuprizone (CPZ) model of multiple sclerosis (MS) is excellent for studying the molecular differences behind damage caused by poisoning. Metabolic in kynurenine pathway (KP) tryptophan (TRP) degradation are observed both MS and a CPZ mouse model. Our goal was to analyze kynurenine, serotonin, indole pathways TRP on periphery, neurodegenerative processes inflammation. In our study, mice were fed with 0.2% toxin 5 weeks. We examined metabolites three breakdown urine, plasma, relevant visceral organs bioanalytical measurements. analyses, we found significant increase plasma TRP, 5-hydroxytryptophan (5-HTP), indole-3-acetic acid (IAA) levels, while decrease concentrations 3-hydroxy-L-kynurenine (3-HK), xanthurenic (XA), kynurenic (KYNA), quinaldic toxin-treated group found. A marked levels 3-HK, XA, KYNA, acid, indole-3-lactic also end Furthermore, noticed urinary XA metabolites, an serotonin 5-hydroxyindoleacetic noticed. treatment resulted elevated tryptamine indoxyl sulfate reduced IAA concentration. Moreover, para-cresyl concentration increased treated group. present showed main metabolic confirmed relationship correlation between content tissues organs. emphasized suppression KP activity particular regard involvement microbiome pathway. Consequently, this first study detail distribution periphery.

Language: Английский

Application of Network Pharmacology in the Treatment of Neurodegenerative Diseases with Traditional Chinese Medicine DOI Creative Commons
Qiang Chen, Guanghui Chen,

Qianyan Wang

et al.

Planta Medica, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 8, 2025

In recent years, the incidence of neurodegenerative diseases, such as Alzheimer’s disease, Parkinson’s Huntington’s and amyotrophic lateral sclerosis, has shown a steadily rising trend, which posed major challenge to global public health. Traditional Chinese Medicine (TCM), with its multi-component multi-target characteristics, offers promising approach for treatment diseases. However, it is difficult comprehensively elucidate complex mechanisms underlying TCM formulations. As an emerging systems biology approach, network pharmacology provided crucial tool uncovering through high-throughput technologies, molecular docking, analysis. This paper reviews advancements in application treating diseases TCM, analyzes current status relevant databases technological methods, discusses limitations research, proposes future directions promote modernization development precision medicine. Keywords: Neurodegenerative Medicine, Network pharmacology, Therapeutic targets

Language: Английский

Citations

0
Plasma and Visceral Organ Kynurenine Metabolites Correlate in the Multiple Sclerosis Cuprizone Animal Model DOI Open Access
Helga Polyák, Zsolt Galla, Cecília Rajda

et al.

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(3), P. 976 - 976

Published: Jan. 24, 2025

The cuprizone (CPZ) model of multiple sclerosis (MS) is excellent for studying the molecular differences behind damage caused by poisoning. Metabolic in kynurenine pathway (KP) tryptophan (TRP) degradation are observed both MS and a CPZ mouse model. Our goal was to analyze kynurenine, serotonin, indole pathways TRP on periphery, neurodegenerative processes inflammation. In our study, mice were fed with 0.2% toxin 5 weeks. We examined metabolites three breakdown urine, plasma, relevant visceral organs bioanalytical measurements. analyses, we found significant increase plasma TRP, 5-hydroxytryptophan (5-HTP), indole-3-acetic acid (IAA) levels, while decrease concentrations 3-hydroxy-L-kynurenine (3-HK), xanthurenic (XA), kynurenic (KYNA), quinaldic toxin-treated group found. A marked levels 3-HK, XA, KYNA, acid, indole-3-lactic also end Furthermore, noticed urinary XA metabolites, an serotonin 5-hydroxyindoleacetic noticed. treatment resulted elevated tryptamine indoxyl sulfate reduced IAA concentration. Moreover, para-cresyl concentration increased treated group. present showed main metabolic confirmed relationship correlation between content tissues organs. emphasized suppression KP activity particular regard involvement microbiome pathway. Consequently, this first study detail distribution periphery.

Language: Английский

Citations

0