Development, Optimization, and Stability Study of a Yataprasen Film-Forming Spray for Musculoskeletal Pain Management

Gels, Journal Year: 2025, Volume and Issue: 11(1), P. 64 - 64

Published: Jan. 15, 2025

Yataprasen (YTPS) remedy ethanolic spray, one of the National Thai Traditional Medicine Formulary, is extensively employed in traditional healthcare to manage musculoskeletal pain and inflammation. Despite its widespread use, quality stability YTPS formulation, critical efficacy, safety, patient adherence, have not been comprehensively studied. This research developed optimized a film-forming spray (FFS) formulation extract conducted 6-month evaluation. The FFS shares similarities with gel formulations, particularly ability form cohesive, semi-solid film upon application, enhancing localized drug delivery prolonged contact time. Key physicochemical properties, including density (0.8450–0.9086 g/cm3), pH (4.72–4.95), angle (55.58–60.10°), evaporation time (1.04–1.27 min), theoretical thickness (7.72–13.97 µm), were analyzed across varying storage conditions. Active components β-amyrin stigmasterol demonstrated retention rates 96.78% 68.22%, respectively, under refrigerated conditions, degradation accelerating at higher temperatures. Significant variations density, angle, thickness, concentration observed. Additionally, RP-HPLC method was validated for accurate precise quantification bioactive compounds such as stigmasterol, demonstrating excellent linearity within 10–100 µg/mL range both R2 > 0.999. results confirmed that YTPS-FFS exhibits good HPLC reliable routine control. These findings supported potential standardized effective dosage managing advancing role modernized medicine.

Language: Английский

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Investigation of a Thermoresponsive In Situ Hydrogel Loaded with Nanotriphala: Implications for Antioxidant, Anti-Inflammatory, and Antimicrobial Therapy in Nasal Disorders

Gels, Journal Year: 2025, Volume and Issue: 11(2), P. 106 - 106

Published: Feb. 2, 2025

Oxidative stress plays a crucial role in chronic nasal disorders, contributing to inflammation, tissue damage, and impaired mucosal function, highlighting the need for targeted therapies. Recent advancements drug delivery systems have expanded their applications treating respiratory inflammatory conditions. Among these, hydrogel-based offer prolonged release of active pharmaceutical ingredients (APIs), enhancing therapeutic efficacy reducing dosing frequency. This study initially evaluates antioxidant, anti-inflammatory, antimicrobial, cytotoxic properties Nanotriphala, followed by its incorporation into thermoresponsive situ hydrogel system, which was subsequently developed characterized as novel formulation. Nanotriphala exhibited >90% cell viability significantly reduced nitric oxide (NO) levels 40.55 µg/mL at 250 µg/mL. The key parameters, including viscosity, gelling time, pH, temperature, texture analysis, ex vivo spreadability. Stability assessed under various conditions, mutagenicity antimutagenicity were evaluated using Ames test. Results showed that gelled 34 °C, good spreadability (10.25 ± 0.28 cm), viscosity 227 22 cP, maintained pH 5.75 0.01, with optimal hardness adhesiveness suitable application. It demonstrated antimicrobial activity against E. coli, P. aeruginosa, S. aureus, epidermidis minimal bactericidal concentrations (MBCs) 32, 2, 4, 8 µg/mL, respectively, low (mutagenic index < 2) strong antimutagenic (>60%). gallic acid content 0.5796 0.0218 µg/100 mL. studies confirmed storage 4 °C. These findings suggest loaded is promising system managing oxidative related

Language: Английский

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Post-operative Wound Healing Efficacy of Eucalyptus Camaldulensis Phenolic-rich Extracts Incorporated Hydrogel With Enhanced Antioxidant, Antibacterial, and Anti-inflammatory Activities

Journal of Polymers and the Environment, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 7, 2024

Language: Английский

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Research Progress on the Therapeutic Mechanisms of Stigmasterol for Multiple Diseases

Molecules, Journal Year: 2025, Volume and Issue: 30(9), P. 1874 - 1874

Published: April 23, 2025

Stigmasterol is a plant-derived phytosterol that has attracted considerable attention because of its diverse biological activities and potential therapeutic applications. In this review, the chemical properties, biosynthesis, effects stigmasterol are exhaustively summarized. Furthermore, anti-inflammatory, antioxidant, anticancer, neuroprotective, hypolipidemic have been discussed. Findings from various in vitro vivo studies revealed treating diseases, including cancer, diabetes, neurological disorders, inflammatory conditions. The mechanisms underlying these also discussed, particularly emphasizing regulation key signaling pathways molecular targets, to further clarify role stigmasterol. This review would provide reference for exploring utility as agent, thereby contributing improvement human health.

Language: Английский

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Unveiling the molecular mechanisms of stigmasterol on diabetic retinopathy: BNM framework construction and experimental validation

Frontiers in Medicine, Journal Year: 2025, Volume and Issue: 12

Published: May 9, 2025

Background Diabetic retinopathy (DR), one of the most common complications diabetes, severely impacts patients’ quality life. The combined use traditional Chinese medicines Astragalus, Fructus ligustris, and Cornus officinalis has yielded considerable therapeutic effects in clinical DR treatment. Methods In this study, a multimodule framework (BNM) encompassing bioinformatics, network pharmacology, machine learning (ML) based on molecular fingerprints was innovatively developed to thoroughly investigate mechanisms medicine treating DR. Results A total 40 active components 12 core targets were identified. Enrichment analysis identified key pathways such as VEGF signaling pathway, TNF pathway HIF-1 pathway. Prediction models using targets, PPARG, constructed from GEO database validated via immune infiltration docking, revealing that PPARG may be potential target for Moreover, component medicine, stigmasterol, ML model fingerprints. vivo experiments demonstrated stigmasterol can regulate glucose lipid metabolism, improve systemic inflammatory levels, ameliorate ocular vascular changes by modulating expression PPARG. Conclusion BNM suggests an important treatment DR, with its mechanism potentially related VEGF/VEGFR

Language: Английский

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Phyto-pharmaceuticals as a safe and potential alternative in management of psoriasis: a review

Zeitschrift für Naturforschung C, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 12, 2024

Abstract Psoriasis is a chronic autoimmune skin disease with worldwide prevalence of 1–3 % results from uncontrolled proliferation keratinocytes and affects millions people. While there are various treatment options available, some them may come potential side effects limitations. Recent research has shown that using bioactive compounds originate natural sources lower risk relatively useful in safe management psoriasis. Bioactive molecules naturally available therapeutic efficacy. Some have promising the psoriasis include curcumin, resveratrol, quercetin, epigallocatechin-3-gallate, etc., possess anti-inflammatory, antioxidant, immunomodulatory, anti-proliferative properties, capabilities to suppress overall pathogenesis Moreover, these generally considered as well-tolerated, making for long-term use conditions linked In addition, products also offer more holistic approach treat disease, which appealing many patients. This review explores mitigation either native or incorporated within novel drug delivery. recent clinical findings relation product usage been explored.

Language: Английский

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