Retinal Protective Effect of Mono-Ethyl Fumarate in Experimental Age-Related Macular Degeneration via Anti-Oxidative and Anti-Apoptotic Alterations DOI Open Access

Hara Lee,

Siqi Zhang,

Hong Ryul Ahn

et al.

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(4), P. 1413 - 1413

Published: Feb. 7, 2025

Age-related macular degeneration (AMD) is a leading cause of vision impairment in people over the age 60. Currently, FDA-approved drugs for AMD have various side effects, and there notable lack drug development dry AMD. This study aimed to explore therapeutic effects mono-ethyl fumarate (MEF) on MEF effectively protected ARPE-19 cells from cell death induced by combination A2E blue light exposure. In C57BL/6J mouse model retinal caused sodium iodate, played role preserving thickness maintaining layered structure retina. It was assessed via fundus imaging, optical coherence tomography, hematoxylin eosin staining. Treatment with significantly increased expression antioxidant proteins such as HO-1, NQO1, SOD1 cells. Additionally, treatment levels GPX4 Concurrently, it reduced apoptosis-related factors, Bax/Bcl-2 ratio Caspase -3 cleavage. These findings suggest that may represent promising candidate management

Language: Английский

Retinal Protective Effect of Mono-Ethyl Fumarate in Experimental Age-Related Macular Degeneration via Anti-Oxidative and Anti-Apoptotic Alterations DOI Open Access

Hara Lee,

Siqi Zhang,

Hong Ryul Ahn

et al.

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(4), P. 1413 - 1413

Published: Feb. 7, 2025

Age-related macular degeneration (AMD) is a leading cause of vision impairment in people over the age 60. Currently, FDA-approved drugs for AMD have various side effects, and there notable lack drug development dry AMD. This study aimed to explore therapeutic effects mono-ethyl fumarate (MEF) on MEF effectively protected ARPE-19 cells from cell death induced by combination A2E blue light exposure. In C57BL/6J mouse model retinal caused sodium iodate, played role preserving thickness maintaining layered structure retina. It was assessed via fundus imaging, optical coherence tomography, hematoxylin eosin staining. Treatment with significantly increased expression antioxidant proteins such as HO-1, NQO1, SOD1 cells. Additionally, treatment levels GPX4 Concurrently, it reduced apoptosis-related factors, Bax/Bcl-2 ratio Caspase -3 cleavage. These findings suggest that may represent promising candidate management

Language: Английский

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