The Role of Natural Deep Eutectic Solvents in a Hydrogel Formulation Containing Lidocaine

Pharmaceutics, Journal Year: 2025, Volume and Issue: 17(3), P. 324 - 324

Published: March 2, 2025

Background/Objectives: This study investigates the use of natural deep eutectic solvents (NADESs) in enhancing solubility and skin permeation a lidocaine base, lipophilic form, hydrogel systems. The aim was to develop an environmentally sustainable biocompatible alternative conventional formulations, improving dermal therapeutic efficacy. Methods: base dissolved hydrophilic NADES system composed choline chloride citric acid, facilitating enhanced solubility, likely through new molecular interactions. Then, pH-adjusted hydrogels were formulated optimized by employing 32 full factorial design. Raman nuclear magnetic resonance (NMR) spectroscopy applied evaluate stability optimal formulation. biopharmaceutical properties investigated using vitro drug release studies. In vivo tests assessed physiological parameters such as hydration transepidermal water loss. Results: developed NADES-containing significantly improved lidocaine. Skin studies demonstrated compared with ointment. These improvements, namely formulation its increased permeation, attributed dual effect NADES. Conclusions: represent promising green technology for formulating lidocaine-containing preparations. approach offers biocompatible, natural-based that can enhance bioavailability efficacy topical anesthetics.

Language: Английский

Novel Buccal Xanthan Gum–Hyaluronic Acid Eutectogels with Dual Anti-Inflammatory and Antimicrobial Properties

Gels, Journal Year: 2025, Volume and Issue: 11(3), P. 208 - 208

Published: March 15, 2025

Buccal drug delivery systems often struggle with poor solubility, limited adhesion, and rapid clearance, leading to suboptimal therapeutic outcomes. To address these limitations, we developed a novel hybrid eutectogel composed of xanthan gum (XTG), hyaluronic acid (HA), Natural Deep Eutectic Solvent (NADES) system (choline chloride, sorbitol, glycerol in 2:1:1 mole ratio), incorporating 2.5% ibuprofen (IBU) as model drug. The formulation was optimized using face-centered central composite design enhance the rheological, textural, release properties. eutectogels exhibited shear-thinning behavior (flow index, n = 0.26 ± 0.01), high mucoadhesion (adhesiveness: 2.297 0.142 N·s), sustained over 24 h, governed by Higuchi kinetics (release rate: 237.34 13.61 μg/cm2/min1/2). ex vivo residence time increased substantially NADES incorporation, reaching up 176.7 23.1 min. An anti-inflammatory evaluation showed that reduced λ-carrageenan-induced paw edema within 1 h its efficacy kaolin (p < 0.05), achieving comparable commercial 5% IBU gel, despite lower concentration. Additionally, presented minimum inhibitory concentration for Gram-positive bacteria 25 mg/mL, through direct contact, it microbial viability 100%. Its against Bacillus cereus, Enterococcus faecium, Klebsiella pneumoniae, combined significant properties, positions NADES-based promising multifunctional platform buccal delivery, particularly inflammatory conditions complicated bacterial infections.

Language: Английский

Understanding the solubility behaviour of ibuprofen and xylitol in natural deep eutectic systems through hansen solubility parameters and physicochemical properties

Journal of Molecular Liquids, Journal Year: 2025, Volume and Issue: unknown, P. 127544 - 127544

Published: April 1, 2025

Language: Английский