Indomethacin-encapsulated PLGA nanoparticles improve therapeutic efficacy by increasing apoptosis and reducing motility in glioblastoma cells DOI
Ferhat Bostanci, Aslıhan Şengelen, Yunus Aksüt

et al.

Pharmaceutical Development and Technology, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 18

Published: Dec. 31, 2024

Glioblastoma, with a low survival rate, is an aggressive and difficult-to-treat lethal type of brain cancer. Indomethacin (IND), non-steroidal anti-inflammatory drug, has antitumoral activity in many cancers, including gliomas. However, its poor aqueous solubility critical issue. Nanomaterials are crucial tools for overcoming problems facilitating drug delivery. Herein, polymeric nanoparticle system, poly(lactic-co-glycolic acid) (PLGA) was used to encapsulate IND. Although PLGA FDA-approved copolymer delivery, no trials IND-loaded PLGA-NPs have been conducted treat tumors. Encapsulation success revealed by DLS, zeta potential, TEM, FTIR analysis; IND/PLGA-NPs had nanoscale particle size (160.6 nm), narrow distribution (0.230, PDI), good stability (-23.9 mV). Fluorescence imaging showed that can penetrate U-87MG cells. Short-term/one-hour treatment bound-IND increased the free-IND effect gliomas ⁓10 times/48h 12.39 times/72h. Even against long-term exposure IND, IND/PLGA-NP highly marked result; IC

Language: Английский

Indomethacin-encapsulated PLGA nanoparticles improve therapeutic efficacy by increasing apoptosis and reducing motility in glioblastoma cells DOI
Ferhat Bostanci, Aslıhan Şengelen, Yunus Aksüt

et al.

Pharmaceutical Development and Technology, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 18

Published: Dec. 31, 2024

Glioblastoma, with a low survival rate, is an aggressive and difficult-to-treat lethal type of brain cancer. Indomethacin (IND), non-steroidal anti-inflammatory drug, has antitumoral activity in many cancers, including gliomas. However, its poor aqueous solubility critical issue. Nanomaterials are crucial tools for overcoming problems facilitating drug delivery. Herein, polymeric nanoparticle system, poly(lactic-co-glycolic acid) (PLGA) was used to encapsulate IND. Although PLGA FDA-approved copolymer delivery, no trials IND-loaded PLGA-NPs have been conducted treat tumors. Encapsulation success revealed by DLS, zeta potential, TEM, FTIR analysis; IND/PLGA-NPs had nanoscale particle size (160.6 nm), narrow distribution (0.230, PDI), good stability (-23.9 mV). Fluorescence imaging showed that can penetrate U-87MG cells. Short-term/one-hour treatment bound-IND increased the free-IND effect gliomas ⁓10 times/48h 12.39 times/72h. Even against long-term exposure IND, IND/PLGA-NP highly marked result; IC

Language: Английский

Citations

0