Treatment of lung diseases via nanoparticles and nanorobots: Are these viable alternatives to overcome current treatments?
Materials Today Bio,
Journal Year:
2025,
Volume and Issue:
31, P. 101616 - 101616
Published: Feb. 26, 2025
Language: Английский
Lessons Learned from the COVID-19 Pandemic: The Intranasal Administration as a route for treatment – A Patent Review
Pharmaceutical Development and Technology,
Journal Year:
2025,
Volume and Issue:
unknown, P. 1 - 33
Published: April 5, 2025
The
COVID-19
pandemic
exposed
the
fragility
of
today's
marketed
treatments
for
respiratory
infections.
As
a
primary
site
infection,
upper
airways
may
represent
key
access
route
control
and
treatment
these
conditions.
present
study
aims
to
explore
identify,
through
patent
review,
novelty
therapies
that
use
intranasal
drug
administration.
A
search
was
carried
out
in
Wipo
Espacenet,
using
descriptors
"COVID-19
OR
SARS-CoV
2"
AND
"treatment
therapy"
NOT
"vaccine
immunizing"
classification
"A61K9/0043".
Of
151
patents
identified,
we
excluded
73
duplicates,
36
documents
meet
criteria
adopted
exclusion
(not
nasally
administered
formulations,
vaccines,
post
treatments,
uncertain
administration
or
form).
We
identified
78
unique
on
databases,
which
42
were
selected
this
review.
revealed
pathway
not
only
repositioning
but
also
plant-derived
biological
molecules.
Overall,
new
formulations
variety
known
drugs
natural
products
incorporated
carrier
systems
devices
delivery
Thus,
remains
promising
strategy
delivery,
offering
direct
infection
warranting
further
exploration.
Language: Английский
Immune Modulation with Oral DNA/RNA Nanoparticles
Pharmaceutics,
Journal Year:
2025,
Volume and Issue:
17(5), P. 609 - 609
Published: May 4, 2025
The
oral
delivery
of
DNA/RNA
nanoparticles
represents
a
transformative
approach
in
immunotherapy
and
vaccine
development.
These
enable
targeted
immune
modulation
by
delivering
genetic
material
to
specific
cells
the
gut-associated
system,
triggering
both
mucosal
systemic
responses.
Unlike
parenteral
administration,
route
offers
unique
immunological
environment
that
supports
tolerance
activation,
depending
on
formulation
design.
This
review
explores
underlying
mechanisms
nanoparticles,
their
design
strategies,
recent
advances
application.
Emphasis
is
placed
strategies
overcome
physiological
barriers
such
as
acidic
pH,
enzymatic
degradation,
mucus
entrapment,
epithelial
tight
junctions.
Special
attention
given
role
lymphoid
tissue
mediating
responses
therapeutic
potential
these
systems
platforms,
food
allergies,
autoimmune
diseases,
chronic
inflammation.
Despite
challenges,
nanoparticle
support
translation
technologies
into
clinical
applications
for
immunomodulation
vaccination.
Language: Английский