Immune Modulation with Oral DNA/RNA Nanoparticles DOI Creative Commons
Ulpan Kart, Aigul Raimbekova, Sergey Yegorov

et al.

Pharmaceutics, Journal Year: 2025, Volume and Issue: 17(5), P. 609 - 609

Published: May 4, 2025

The oral delivery of DNA/RNA nanoparticles represents a transformative approach in immunotherapy and vaccine development. These enable targeted immune modulation by delivering genetic material to specific cells the gut-associated system, triggering both mucosal systemic responses. Unlike parenteral administration, route offers unique immunological environment that supports tolerance activation, depending on formulation design. This review explores underlying mechanisms nanoparticles, their design strategies, recent advances application. Emphasis is placed strategies overcome physiological barriers such as acidic pH, enzymatic degradation, mucus entrapment, epithelial tight junctions. Special attention given role lymphoid tissue mediating responses therapeutic potential these systems platforms, food allergies, autoimmune diseases, chronic inflammation. Despite challenges, nanoparticle support translation technologies into clinical applications for immunomodulation vaccination.

Language: Английский

Treatment of lung diseases via nanoparticles and nanorobots: Are these viable alternatives to overcome current treatments? DOI Creative Commons
Meekha George, Rabah Boukherroub,

Amitav Sanyal

et al.

Materials Today Bio, Journal Year: 2025, Volume and Issue: 31, P. 101616 - 101616

Published: Feb. 26, 2025

Language: Английский

Citations

1

Lessons Learned from the COVID-19 Pandemic: The Intranasal Administration as a route for treatment – A Patent Review DOI

Nicole Menezes Pinto,

Marcos Rafael das Chagas Mendonça, Jeferson da Silva dos Santos

et al.

Pharmaceutical Development and Technology, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 33

Published: April 5, 2025

The COVID-19 pandemic exposed the fragility of today's marketed treatments for respiratory infections. As a primary site infection, upper airways may represent key access route control and treatment these conditions. present study aims to explore identify, through patent review, novelty therapies that use intranasal drug administration. A search was carried out in Wipo Espacenet, using descriptors "COVID-19 OR SARS-CoV 2" AND "treatment therapy" NOT "vaccine immunizing" classification "A61K9/0043". Of 151 patents identified, we excluded 73 duplicates, 36 documents meet criteria adopted exclusion (not nasally administered formulations, vaccines, post treatments, uncertain administration or form). We identified 78 unique on databases, which 42 were selected this review. revealed pathway not only repositioning but also plant-derived biological molecules. Overall, new formulations variety known drugs natural products incorporated carrier systems devices delivery Thus, remains promising strategy delivery, offering direct infection warranting further exploration.

Language: Английский

Citations

0

Immune Modulation with Oral DNA/RNA Nanoparticles DOI Creative Commons
Ulpan Kart, Aigul Raimbekova, Sergey Yegorov

et al.

Pharmaceutics, Journal Year: 2025, Volume and Issue: 17(5), P. 609 - 609

Published: May 4, 2025

The oral delivery of DNA/RNA nanoparticles represents a transformative approach in immunotherapy and vaccine development. These enable targeted immune modulation by delivering genetic material to specific cells the gut-associated system, triggering both mucosal systemic responses. Unlike parenteral administration, route offers unique immunological environment that supports tolerance activation, depending on formulation design. This review explores underlying mechanisms nanoparticles, their design strategies, recent advances application. Emphasis is placed strategies overcome physiological barriers such as acidic pH, enzymatic degradation, mucus entrapment, epithelial tight junctions. Special attention given role lymphoid tissue mediating responses therapeutic potential these systems platforms, food allergies, autoimmune diseases, chronic inflammation. Despite challenges, nanoparticle support translation technologies into clinical applications for immunomodulation vaccination.

Language: Английский

Citations

0