Intestinal Microbiota Composition in Patients with Type 2 Diabetes and Effects of Oral Antidiabetics DOI Open Access
Ahmet Toygar Kalkan, Göknur Yorulmaz, Ayşen Akalın

et al.

Journal of Clinical Medicine, Journal Year: 2025, Volume and Issue: 14(8), P. 2786 - 2786

Published: April 17, 2025

Introduction: The cause–effect relationships between microbiota composition changes and type 2 diabetes (T2D) are complex, likely involving two-way interactions, require further elucidation. Few studies have examined the interactions of antidiabetic drugs with gut microbiota. This study’s goal was to evaluate patients at first diagnosis again after 12 weeks taking oral drugs. Methods: We performed a fecal analysis adult who recently received T2D healthy adults. compared compositions controls; we also evaluated from baseline treatment in total group receiving antidiabetics, as well subgroups metformin linagliptin. Results: alpha diversity beta indices were different controls. LEfSe showed that, genus level, Lactobacillus, Rothia, Collinsella, Eubacterium genera increased relative abundance while, species Rothia mucilaginosa, Collinsella aerofaciens, bioforme strains found be dominant group. Faecalibacterium level prausnitzii strain weeks. After intervention, significantly lower control At end 12th week, Gemmiger group, formicilis aerofaciens being level; Bacteroides Alistipes Prevotella stercorea finegoldii dominant. There no difference results linagliptin treatment. formicilis, Ruminococcus bromii, Lactobacillus ruminis predominant start treatment; however, weeks, became predominant. Conclusions: report that there is substantial change T2D. Oral treatments, especially metformin, some beneficial effects on composition. explored interaction microbiota; research will elucidate clinical impact these diabetes.

Language: Английский

Intestinal Microbiota Composition in Patients with Type 2 Diabetes and Effects of Oral Antidiabetics DOI Open Access
Ahmet Toygar Kalkan, Göknur Yorulmaz, Ayşen Akalın

et al.

Journal of Clinical Medicine, Journal Year: 2025, Volume and Issue: 14(8), P. 2786 - 2786

Published: April 17, 2025

Introduction: The cause–effect relationships between microbiota composition changes and type 2 diabetes (T2D) are complex, likely involving two-way interactions, require further elucidation. Few studies have examined the interactions of antidiabetic drugs with gut microbiota. This study’s goal was to evaluate patients at first diagnosis again after 12 weeks taking oral drugs. Methods: We performed a fecal analysis adult who recently received T2D healthy adults. compared compositions controls; we also evaluated from baseline treatment in total group receiving antidiabetics, as well subgroups metformin linagliptin. Results: alpha diversity beta indices were different controls. LEfSe showed that, genus level, Lactobacillus, Rothia, Collinsella, Eubacterium genera increased relative abundance while, species Rothia mucilaginosa, Collinsella aerofaciens, bioforme strains found be dominant group. Faecalibacterium level prausnitzii strain weeks. After intervention, significantly lower control At end 12th week, Gemmiger group, formicilis aerofaciens being level; Bacteroides Alistipes Prevotella stercorea finegoldii dominant. There no difference results linagliptin treatment. formicilis, Ruminococcus bromii, Lactobacillus ruminis predominant start treatment; however, weeks, became predominant. Conclusions: report that there is substantial change T2D. Oral treatments, especially metformin, some beneficial effects on composition. explored interaction microbiota; research will elucidate clinical impact these diabetes.

Language: Английский

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