Cannabis: Zone Aspects of Raw Plant Components in Sport—A Narrative Review

Nutrients, Journal Year: 2025, Volume and Issue: 17(5), P. 861 - 861

Published: Feb. 28, 2025

Objectives/Background: The Cannabis genus contain a mixture of cannabinoids and other minor components which have been studied so far. In this narrative review, we highlight the main aspects polarized discussion between abuse toxicity versus benefits compounds found in sativa plant. Methods: We investigated databases such as PubMed, Google Scholar, Web Science World Anti-doping Agency (WADA) documents for scientific publications that can elucidate heated related to negative addiction, organ damage improved sports performance medical benefits, particularly athletes, some are promising nutrients. Results: Scientific arguments bring forward harmful effects cannabinoids, ethical legislative their usage doping substances sports. present synthesis metabolism cannabis along with identification methods routine anti-doping tests. Numerous studies attest beneficial effects, could therapeutic advantage athletes case injuries. These recommend nutrients, well potential pharmacological agents. Conclusions Future Perspectives: From perspective both illegal use investigators sport, there many interpretations, presented discussed review. Despite recent on species, is very little research active especially large groups compared placebo. may complete current vision topic clarify hypotheses launched discussions

Language: Английский

Targeting the Endocannabinoidome: A Novel Approach to Managing Extraintestinal Complications in Inflammatory Bowel Disease

Pharmaceuticals, Journal Year: 2025, Volume and Issue: 18(4), P. 478 - 478

Published: March 27, 2025

Background: Inflammatory bowel disease (IBD) is a chronic inflammatory disorder marked by persistent gastrointestinal inflammation and spectrum of systemic effects, including extraintestinal manifestations (EIMs) that impact the joints, skin, liver, eyes. Conventional therapies primarily target intestinal inflammation, yet they frequently fail to ameliorate these complications. Recent investigations have highlighted complex interplay among immune system, gut, nervous system in IBD pathogenesis, thereby underscoring need for innovative therapeutic approaches. Methods: We conducted comprehensive literature search using databases such as PubMed, Scopus, Web Science, Science Direct, Google Scholar. Keywords “cannabinoids”, “endocannabinoid system”, “endocannabinoidome”, “inflammatory disease”, “extraintestinal manifestations” were used identify peer-reviewed original research review articles explore role endocannabinoidome (eCBome) IBD. Results: Emerging evidence suggests eCBome—a network comprising lipid mediators, receptors (e.g., CB1, CB2, GPR55, GPR35, PPARα, TRPV1), metabolic enzymes—plays critical modulating responses, maintaining gut barrier integrity, regulating inflammation. Targeting eCBome not only improves but also appears mitigate metabolic, neurological, complications arthritis, liver dysfunction, dermatological disorders. Conclusions: Modulation represents promising strategy management addressing both local components. These findings advocate further mechanistic studies develop targeted interventions leverage novel avenue

Language: Английский