Chrysin Counteracts Sodium Hydroxide-Induced Alkali Esophageal Burn by Regulating Beclin-1/HO-1/NQO1, PERK/IRE1-α/ATF-6, Oxidative Stress, Inflammation, Apoptosis Signaling Pathways and Ki-67, EGF Expressions in Rats

Bratislavské lekárske listy/Bratislava medical journal, Journal Year: 2025, Volume and Issue: unknown

Published: April 14, 2025

Abstract Aim Alkali-esophageal burn due to ingestion of corrosive substances is an important clinical entity that can be seen in all age groups, especially children. Chrysin a natural flavonoid compound with wide range biological activities, including antioxidant, anti-inflammatory, antiapoptotic, and anticancer effects. This study aimed ascertain the preventive efficacy chrysin treatment alkali-esophageal burns. Materials Methods Rats were administered 0.2 ml 25% NaOH orally CHR at 25 50 mg/kg intraperitoneally for four days. The levels oxidative stress, ER inflammation, damage, apoptotic autophagic cell death esophageal tissues analyzed using biochemical molecular methods. Additionally, tissue structure function examined histological Results alleviated NaOH-induced increased stress by decreasing MDA increasing antioxidants. inflammation damage inhibiting NF-κB signaling pathway. decreased Caspase-3, Bax antiapoptotic Bcl-2. Moreover, reduced damage. facilitated restoration impaired structural integrity Ki-67 EGF levels, contributing healing process. Conclusion exhibited anti-autophagic, anti-oxidant properties alkali burns, as well effect on reducing injury. facilitates maintains integrity. Graphical abstract

Language: Английский

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Investigation of the attenuation effect of Licorice on the toxicity of Rhubarb using a P-gp lipid raft bioaffinity chromatography

Journal of Ethnopharmacology, Journal Year: 2025, Volume and Issue: 349, P. 119929 - 119929

Published: May 5, 2025

Language: Английский

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Could hesperetin ameliorate doxorubicin-induced nephrotoxicity in rats via its antioxidant, antiapoptotic, and anti-inflammatory properties?

Tissue and Cell, Journal Year: 2025, Volume and Issue: 96, P. 102951 - 102951

Published: May 2, 2025

Language: Английский

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Mitigating Oxidative Stress and Inflammation: The Protective Role of β-lapachone in Kidney Disease

Inflammation, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 18

Published: Jan. 1, 2025

Language: Английский

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