Aloe vera Phytochemicals as Potential Antibacterial Agents Against Multidrug‐Resistant Pseudomonas aeruginosa DOI Creative Commons
Awadh Alanazi, Sonia Younas, Muhammad Umer Khan

et al.

International Journal of Microbiology, Journal Year: 2025, Volume and Issue: 2025(1)

Published: Jan. 1, 2025

Multidrug‐resistant (MDR) Pseudomonas aeruginosa poses a global challenge due to its high virulence and resistance mechanisms, which lead persistent infections. This study explored the efficacy of active compounds Aloe vera as alternative treatments against MDR P. isolates. A total 283 isolates were obtained from sputum throat samples. The antibiotic these was evaluated several classes. minimum inhibitory concentration (MIC) A. –derived phytochemicals individually assessed; lupeol found be potent phytochemical with lowest MIC (125 μ g/mL). physicochemical properties toxicity further using SwissADME, StopTox, Protox 3.0. Genetic analysis identified mutations in AmpC protein key factor resistance; consequently, molecular docking studies examined interactions between AmpC. Most exhibited pronounced resistance, while demonstrated favorable pharmacological strong binding amino acids Of phytochemicals, aloe‐emodin showed most promising antibacterial activity. These findings underscore potential for clinical application combating drug‐resistant bacterial

Language: Английский

Staphylococcus aureus: A Review of the Pathogenesis and Virulence Mechanisms DOI Creative Commons

Rahima Touaitia,

Assia Mairi, Nasir A. Ibrahim

et al.

Antibiotics, Journal Year: 2025, Volume and Issue: 14(5), P. 470 - 470

Published: May 6, 2025

Staphylococcus aureus is a formidable human pathogen responsible for infections ranging from superficial skin lesions to life-threatening systemic diseases. This review synthesizes current knowledge on its pathogenesis, emphasizing colonization dynamics, virulence mechanisms, biofilm formation, and antibiotic resistance. By analyzing studies PubMed, Scopus, Web of Science, we highlight the pathogen’s adaptability, driven by surface adhesins (e.g., ClfB, SasG), secreted toxins PVL, TSST-1), metabolic flexibility in iron acquisition amino acid utilization. Nasal, skin, oropharyngeal are reservoirs invasive infections, with persistence horizontal gene transfer exacerbating antimicrobial resistance, particularly methicillin-resistant S. (MRSA). The underscores clinical challenges multidrug-resistant strains, including vancomycin resistance decolonization strategies’ failure target single anatomical sites. Key discussions address host–microbiome interactions, immune evasion tactics, limitations therapies. Future directions advocate novel anti-virulence therapies, multi-epitope vaccines, AI-driven diagnostics combat evolving Strengthening global surveillance interdisciplinary collaboration critical mitigating public health burden aureus.

Language: Английский

Citations

0
Aloe vera Phytochemicals as Potential Antibacterial Agents Against Multidrug‐Resistant Pseudomonas aeruginosa DOI Creative Commons
Awadh Alanazi, Sonia Younas, Muhammad Umer Khan

et al.

International Journal of Microbiology, Journal Year: 2025, Volume and Issue: 2025(1)

Published: Jan. 1, 2025

Multidrug‐resistant (MDR) Pseudomonas aeruginosa poses a global challenge due to its high virulence and resistance mechanisms, which lead persistent infections. This study explored the efficacy of active compounds Aloe vera as alternative treatments against MDR P. isolates. A total 283 isolates were obtained from sputum throat samples. The antibiotic these was evaluated several classes. minimum inhibitory concentration (MIC) A. –derived phytochemicals individually assessed; lupeol found be potent phytochemical with lowest MIC (125 μ g/mL). physicochemical properties toxicity further using SwissADME, StopTox, Protox 3.0. Genetic analysis identified mutations in AmpC protein key factor resistance; consequently, molecular docking studies examined interactions between AmpC. Most exhibited pronounced resistance, while demonstrated favorable pharmacological strong binding amino acids Of phytochemicals, aloe‐emodin showed most promising antibacterial activity. These findings underscore potential for clinical application combating drug‐resistant bacterial

Language: Английский

Citations

0