Carotenoids in Skin Photoaging: Unveiling Protective Effects, Molecular Insights, and Safety and Bioavailability Frontiers DOI Creative Commons

Yingchao Ma,

Chengxiang Li,

Wan-Ping Su

et al.

Antioxidants, Journal Year: 2025, Volume and Issue: 14(5), P. 577 - 577

Published: May 11, 2025

Skin photoaging, driven primarily by ultraviolet radiation, remains a critical dermatological concern. Carotenoids, class of natural pigments with potent antioxidant properties, have emerged as promising agents for preventing and mitigating photoaging. This review comprehensively integrates current understanding regarding the triggers skin oxidative stress their associated signal pathways, photoprotective roles mechanisms carotenoids, well bioavailability. Common C40 such β-carotene, lycopene, astaxanthin, lutein, zeaxanthin demonstrate remarkable activity, attributed to conjugated double bond structures. Many studies demonstrated that both oral topical administration these carotenoids can effectively alleviate Specifically, they play crucial role in promoting formation new barrier enhancing production collagen elastin, key structural proteins essential maintaining integrity elasticity. Mechanistically, combat photoaging scavenging reactive oxygen species modulating responsive including MAPK, Nrf2, NF-κB. Notably, we also anticipate anti-photoaging potential novel particular emphasis on bacterioruberin, C50 carotenoid derived from halophilic archaea. Bacterioruberin exhibits superior radical capacity, outperforming conventional carotenoids. Furthermore, when considering application aspects safe dosage, bioavailability, possible long term usage issues, allergies pigmentation disorders, must be taken into account. underscores mechanism providing strategies theoretical basis prevention treatment

Language: Английский

Carotenoids in Skin Photoaging: Unveiling Protective Effects, Molecular Insights, and Safety and Bioavailability Frontiers DOI Creative Commons

Yingchao Ma,

Chengxiang Li,

Wan-Ping Su

et al.

Antioxidants, Journal Year: 2025, Volume and Issue: 14(5), P. 577 - 577

Published: May 11, 2025

Skin photoaging, driven primarily by ultraviolet radiation, remains a critical dermatological concern. Carotenoids, class of natural pigments with potent antioxidant properties, have emerged as promising agents for preventing and mitigating photoaging. This review comprehensively integrates current understanding regarding the triggers skin oxidative stress their associated signal pathways, photoprotective roles mechanisms carotenoids, well bioavailability. Common C40 such β-carotene, lycopene, astaxanthin, lutein, zeaxanthin demonstrate remarkable activity, attributed to conjugated double bond structures. Many studies demonstrated that both oral topical administration these carotenoids can effectively alleviate Specifically, they play crucial role in promoting formation new barrier enhancing production collagen elastin, key structural proteins essential maintaining integrity elasticity. Mechanistically, combat photoaging scavenging reactive oxygen species modulating responsive including MAPK, Nrf2, NF-κB. Notably, we also anticipate anti-photoaging potential novel particular emphasis on bacterioruberin, C50 carotenoid derived from halophilic archaea. Bacterioruberin exhibits superior radical capacity, outperforming conventional carotenoids. Furthermore, when considering application aspects safe dosage, bioavailability, possible long term usage issues, allergies pigmentation disorders, must be taken into account. underscores mechanism providing strategies theoretical basis prevention treatment

Language: Английский

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