Dual-Modulation Design to Develop ER-Targeting NIR Pyroptosis Inducers with Type I PDT Efficacy and Amplified Antitumor Immunity DOI
Yan Ma,

Mengfan Han,

Hanchen Zhu

et al.

Analytical Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: June 2, 2025

Recently, immunogenic cell death (ICD) activated by phototherapy has attracted increasing attention in anticancer immunotherapy. Pyroptosis, a lysogenic and inflammatory form of distinct from apoptosis, is considered to enhance the ICD process tumor cells. Endoplasmic reticulum (ER)-targeted pyroptosis induced reported promote release cytokines DAMPs amplify response as result. However, specific stable tracking ER more difficult than that other organelles. In this work, we introduce dual-modulation strategy regulate effect ER-targeting unit p-toluenesulfonamide twisting conjugation motif on modification heptamethine cyanine. A dimer dye (T780T-ER) with structure four molecules ultimately optimized, which can specifically target good stability efficient Type I PDT capability. Under PDT/PTT stimulation, T780T-ER activates sufficient causes DAMPs. vivo, promoted strengthened antitumor immunity are confirmed against growth primary distant tumors. Summarily, study highlights importance multiple-modulation developing ER-targeted photosensitizers proposes molecule an stress-dependent inducer

Language: Английский

Dual-Modulation Design to Develop ER-Targeting NIR Pyroptosis Inducers with Type I PDT Efficacy and Amplified Antitumor Immunity DOI
Yan Ma,

Mengfan Han,

Hanchen Zhu

et al.

Analytical Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: June 2, 2025

Recently, immunogenic cell death (ICD) activated by phototherapy has attracted increasing attention in anticancer immunotherapy. Pyroptosis, a lysogenic and inflammatory form of distinct from apoptosis, is considered to enhance the ICD process tumor cells. Endoplasmic reticulum (ER)-targeted pyroptosis induced reported promote release cytokines DAMPs amplify response as result. However, specific stable tracking ER more difficult than that other organelles. In this work, we introduce dual-modulation strategy regulate effect ER-targeting unit p-toluenesulfonamide twisting conjugation motif on modification heptamethine cyanine. A dimer dye (T780T-ER) with structure four molecules ultimately optimized, which can specifically target good stability efficient Type I PDT capability. Under PDT/PTT stimulation, T780T-ER activates sufficient causes DAMPs. vivo, promoted strengthened antitumor immunity are confirmed against growth primary distant tumors. Summarily, study highlights importance multiple-modulation developing ER-targeted photosensitizers proposes molecule an stress-dependent inducer

Language: Английский

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