The Journal of Physical Chemistry B,
Journal Year:
2024,
Volume and Issue:
128(16), P. 3833 - 3843
Published: April 11, 2024
The
construction
of
the
stratum
corneum
(SC)
is
crucial
to
problems
transdermal
drug
delivery.
SC
consists
keratinocyte
layers
and
lipid
matrix
surrounding
it.
Among
them,
barrier
for
many
exogenous
molecules,
mainly
composed
ceramides
(CERs),
free
fatty
acids
(FFA),
cholesterol
(CHOL).
In
this
work,
we
developed
single-component
(CERs,
CER-NS,
CER-EOS)
six
three-component
models,
each
model
was
simulated
by
using
GROMOS-54A7
force
field.
Short-period
phase
(SPP)
long-period
(LPP)
systems
were
established
separately,
area
per
(APL),
thickness,
order
carbon
chain
(S
Pharmaceutics,
Journal Year:
2024,
Volume and Issue:
16(2), P. 222 - 222
Published: Feb. 3, 2024
Colchicine
(COL),
a
widely
used
natural
drug,
has
potent
anti-inflammatory
effects;
however,
as
narrow
therapeutic
index
its
clinical
application
is
limited
by
serious
gastrointestinal
adverse
effects,
and
only
oral
formulations
are
currently
marketed
worldwide.
Recent
studies
have
shown
that
transdermal,
injection,
drug
delivery
the
three
main
strategies
for
COL.
This
article
elaborates
on
research
progress
of
different
in
terms
toxicity
reduction
efficacy
enhancement,
depicting
transdermal
route
can
avoid
first-pass
effect
traumatic
pain
associated
with
injection
routes,
respectively.
Therefore,
such
dosage
form
holds
significant
promise
requires
development
further
to
investigate
effective
COL
formulations.
In
addition,
permeation-promoting
technologies
utilized
systems
briefly
discussed.
expected
provide
scientific
ideas
theoretical
guidance
future
exploration
strategies.
Cosmetics,
Journal Year:
2024,
Volume and Issue:
11(2), P. 51 - 51
Published: April 2, 2024
Microneedling,
also
known
as
percutaneous
collagen
induction,
using
microneedling
devices
and
fabricated
microneedle
patches,
has
been
widely
employed
in
cosmetic
applications
for
acne
scar
treatment,
skin
care,
hair
loss,
melasma,
rejuvenation,
cancer.
The
micro-channels
formed
by
through
the
stratum
corneum
facilitate
delivery
of
agents
stimulate
elastin
production
inducing
wound-healing
cascade,
keeping
shiny
wrinkle-free.
Several
agents,
such
ascorbic
acid,
hyaluronic
retinoids,
niacinamide,
peptides,
have
delivered
microneedling.
This
review
aims
to
highlight
use
patches
facilitating
layers.
Moreover,
differences
between
devices,
commonly
used
alone
or
combinational
treatments
with
topical
formulations,
are
explored.
Furthermore,
safety
terms
irritation,
pain
sensation,
systemic
infection,
chemical
biological
materials
fabrication
microneedles
is
discussed.
PLOS Digital Health,
Journal Year:
2024,
Volume and Issue:
3(4), P. e0000483 - e0000483
Published: April 3, 2024
The
transdermal
route
of
drug
administration
has
gained
popularity
for
its
convenience
and
bypassing
the
first-pass
metabolism.
Accurate
skin
permeability
prediction
is
crucial
successful
delivery
(TDD).
In
this
study,
we
address
critical
need
to
enhance
TDD.
A
dataset
comprising
441
records
140
molecules
with
diverse
LogKp
values
was
characterized.
descriptor
calculation
yielded
145
relevant
descriptors.
Machine
learning
models,
including
MLR,
RF,
XGBoost,
CatBoost,
LGBM,
ANN,
were
employed
regression
analysis.
Notably,
gradient
boosting
models
outperformed
others,
demonstrating
superior
predictive
accuracy.
Key
descriptors
influencing
permeability,
such
as
hydrophobicity,
hydrogen
bond
donors,
acceptors,
topological
polar
surface
area,
identified
visualized.
Cluster
analysis
applied
FDA-approved
(2326
compounds)
revealed
four
distinct
clusters
significant
differences
in
molecular
characteristics.
Predicted
these
offered
insights
into
variations
among
drugs.
Furthermore,
an
investigation
patterns
across
83
classes
drugs
based
on
ATC
code
showcased
differences,
providing
valuable
information
development
strategies.
study
underscores
importance
accurate
TDD,
emphasizing
performance
nonlinear
machine
models.
key
contribute
a
nuanced
understanding
characteristics
These
findings
offer
actionable
design,
formulation,
prioritization
optimum
properties,
potentially
reducing
reliance
costly
experimental
testing.
Future
research
directions
include
offering
promising
applications
pharmaceutical
formulation
within
burgeoning
field
computer-aided
design.
The Journal of Physical Chemistry B,
Journal Year:
2024,
Volume and Issue:
128(16), P. 3833 - 3843
Published: April 11, 2024
The
construction
of
the
stratum
corneum
(SC)
is
crucial
to
problems
transdermal
drug
delivery.
SC
consists
keratinocyte
layers
and
lipid
matrix
surrounding
it.
Among
them,
barrier
for
many
exogenous
molecules,
mainly
composed
ceramides
(CERs),
free
fatty
acids
(FFA),
cholesterol
(CHOL).
In
this
work,
we
developed
single-component
(CERs,
CER-NS,
CER-EOS)
six
three-component
models,
each
model
was
simulated
by
using
GROMOS-54A7
force
field.
Short-period
phase
(SPP)
long-period
(LPP)
systems
were
established
separately,
area
per
(APL),
thickness,
order
carbon
chain
(S
