Apremilast Cocrystals with Phenolic Coformers DOI Creative Commons
Yelizaveta Naumkina, Bohumil Kratochvíl, Е. И. Короткова

et al.

Molecules, Journal Year: 2024, Volume and Issue: 29(24), P. 6060 - 6060

Published: Dec. 23, 2024

Apremilast (APR) is an anti-inflammatory drug commonly used in the treatment of psoriasis. In efforts to enhance its solubility, several cocrystals with similar structural features have been developed. This study investigates cocrystallization APR four phenolic-type coformers: phenol, catechol, pyrogallol, and hydroxyquinol. These coformers differ number position their hydroxyl groups, melting points varying by as much 100 °C. Four novel cocrystal forms were synthesized, purified, characterized using X-Ray diffraction thermal analysis techniques. Surprisingly, resulting exhibited minimal differences points. The molecular packing appears limit network-forming potential a conclusion supported solved crystal structures, Hirshfeld surface analysis, differential scanning calorimetry (DSC) results.

Language: Английский

Pharmaceutical cocrystals: Unlocking the potential of challenging drug candidates DOI
Jidnyasa Pantwalawalkar, Niraj Kale, Sopan Nangare

et al.

Journal of Drug Delivery Science and Technology, Journal Year: 2024, Volume and Issue: unknown, P. 106572 - 106572

Published: Dec. 1, 2024

Language: Английский

Citations

2
Isostructural Levamisole Hydrochloride Ionic Cocrystal Solvates: High Z″ with a Low Melting Point DOI
Yi-Chen Yao, Zhe Jin, Minghuang Hong

et al.

Crystal Growth & Design, Journal Year: 2023, Volume and Issue: 24(1), P. 554 - 566

Published: Dec. 6, 2023

Levamisole hydrochloride cocrystallizes with hydroquinone in different solvates (methanol, ethanol, water, acetonitrile, and n-propanol), forming the changing Z″ cocrystal from 23 to 3.33. These cocrystals were characterized by using single-crystal powder X-ray diffraction thermal analysis. All consist of 2D planar sheets, which influence value melting point. The findings suggest a method for obtaining high Z crystals through suitable solvents. Topology analysis Hirshfeld surface conducted understand transformation. Further, quantum chemistry was demonstrated as significant tool explain extremely low point change solid forms.

Language: Английский

Citations

3
Optimization of Hot-Melt Extrusion Processing for the Synthesis of Ionic Cocrystals DOI
Dunja Šilić, Biserka Cetina‐Čižmek, Steven A. Ross

et al.

Crystal Growth & Design, Journal Year: 2023, Volume and Issue: 23(10), P. 7355 - 7364

Published: Sept. 18, 2023

Cocrystals are multicomponent crystalline forms that an appealing alternative to modify undesirable properties of drug substances, such as poor solubility and stability. Hot-melt extrusion (HME), a solvent-free, robust, scalable technology, has been proven be suitable approach for cocrystallization several drug-coformer pairs. However, HME mainly implemented the synthesis molecular cocrystals when most marketed products manufactured in form ionic cocrystals. In this study, extruded fluoxetine HCl-succinic acid was investigated using different screw configurations. Ionic by showed complete transformation pair with high purity, improved intrinsic dissolution rates, long-term storage stability compared their counterparts produced solvent evaporation.

Language: Английский

Citations

2
Supramolecular architectures in multicomponent crystals of imidazole-based drugs and trithiocyanuric acid DOI Creative Commons

Anna Ben,

Marta Hoelm, Lilianna Chęcińska

et al.

Acta Crystallographica Section B Structural Science Crystal Engineering and Materials, Journal Year: 2024, Volume and Issue: 80(4), P. 294 - 304

Published: July 1, 2024

The structures of three multicomponent crystals formed with imidazole-based drugs, namely metronidazole, ketoconazole and miconazole, in conjunction trithiocyanuric acid are characterized. Each the obtained adducts represents a different category crystalline molecular forms: cocrystal, salt cocrystal salt. structural analysis revealed that all cases, N—H...N hydrogen bond is responsible for formation acid–base pairs, regardless whether proton transfer occurs or not, these pairs combined to form unique supramolecular motifs by centrosymmetric N—H...S interactions between molecules. complex intermolecular forces acting characteristic patterns discussed from geometric energetic perspectives, involving Hirshfeld surface analysis, pairwise energy estimation, natural orbital calculations.

Language: Английский

Citations

0
Novel lithium ionic cocrystals with benzoic acid derivatives and L-proline: Synthesis, X-ray structures, IR spectrums, DSC analysis, and water solubility DOI
Yanping Li,

Hua Chen,

Jimin Lai

et al.

Journal of Molecular Structure, Journal Year: 2024, Volume and Issue: 1315, P. 138795 - 138795

Published: May 29, 2024

Language: Английский

Citations

0
Apremilast Cocrystals with Phenolic Coformers DOI Creative Commons
Yelizaveta Naumkina, Bohumil Kratochvíl, Е. И. Короткова

et al.

Molecules, Journal Year: 2024, Volume and Issue: 29(24), P. 6060 - 6060

Published: Dec. 23, 2024

Apremilast (APR) is an anti-inflammatory drug commonly used in the treatment of psoriasis. In efforts to enhance its solubility, several cocrystals with similar structural features have been developed. This study investigates cocrystallization APR four phenolic-type coformers: phenol, catechol, pyrogallol, and hydroxyquinol. These coformers differ number position their hydroxyl groups, melting points varying by as much 100 °C. Four novel cocrystal forms were synthesized, purified, characterized using X-Ray diffraction thermal analysis techniques. Surprisingly, resulting exhibited minimal differences points. The molecular packing appears limit network-forming potential a conclusion supported solved crystal structures, Hirshfeld surface analysis, differential scanning calorimetry (DSC) results.

Language: Английский

Citations

0