Scaffold for the Minimally Invasive Repair of Soft Tissue Inspired by Soggy Shrunk Puffed Food DOI Creative Commons
Yong He

Research Square (Research Square), Journal Year: 2023, Volume and Issue: unknown

Published: Aug. 4, 2023

Abstract Minimally invasive injection of tissue engineering scaffolds has been gaining attention due to featuring several advantages requiring a small incision, entailing simple operation procedure, and involving quick recovery. However, it remains challenge because larger must pass through an extremely thin needle. Herein, inspired by the phenomenon that puffed food becomes soggy shrinks when exposed air, novel scaffold treatment method is proposed; namely, lyophilization & dampening (L&D) treatment, which reduces printed hydrogel volume around 90%. Lyophilization can remove water inside scaffolds; Dampening is, placing freeze-dried into vapor atmosphere, make shrunk suitable size for minimally injection. Moreover, unlike existing air-dried technique feature high mechanical modulus, developed herein low modulus (2.88 kPa), thus minimizing foreign body sensation after implantation. Furthermore, injected rapidly swell their original act as regeneration media. Accordingly, specialized tool namely “BioGun” designed ("BioBullet”). This strategy would potentially overcome technical bottlenecks limiting clinical soft defect repair.

Language: Английский

Tissue engineering in otology: a review of achievements DOI
Reza Kaboodkhani, Davood Mehrabani, Armaghan Moghaddam

et al.

Journal of Biomaterials Science Polymer Edition, Journal Year: 2024, Volume and Issue: 35(7), P. 1105 - 1153

Published: Feb. 22, 2024

Tissue engineering application in otology spans a distance from the pinna to auditory nerve covered with specialized tissues and functions such as sense of hearing aesthetics. It holds potential address barriers lack donor tissue, poor tissue match, transplant rejection through provision new healthy similar host possesses capacity renew, regenerate, repair in-vivo was shown be bypasses for any need immunosuppression. This review aims investigate evaluate achievements challenges external, middle inner ear sections. Since gaining recent knowledge training on use different scaffolds is essential specialists who look recovery function aesthetics patients, it this how utilizing cell transplantation, regenerative medicine can provide advancements fit patients' needs.

Language: Английский

Citations

0
Photopolymerizable materials for biocompatible implantable matrices DOI Creative Commons

IS Rudik,

AV Mironov,

В. С. Кузнецова

et al.

Bulletin of Russian State Medical University, Journal Year: 2024, Volume and Issue: 2024(4)

Published: Aug. 1, 2024

The review considers photopolymerizable compositions based on biocompatible polymers for regenerative medicine. Assessment of the physical-mechanical and biological properties polymeric matrices, polyethyleneglycol, lactic acid, collagen, hyaluronic as well effectiveness toxicity various photoinitiator supplements has been performed. Mechanical degradation rate matrices are ensured by selection proportions methacrylated mono-, oligo-, these consist of, while their largely depends systems used. It concluded that it is necessary to search develop methods obtain using compounds capable initiating radical polymerization with lower toxic effect.

Language: Английский

Citations

0
A Simplified Method for the Preparation of Highly Conductive and Flexible Silk Nanofibrils/MXene Membrane DOI Open Access
B.Z. Ding, Chao Teng, Yanxiang Wang

et al.

Materials, Journal Year: 2023, Volume and Issue: 16(21), P. 6960 - 6960

Published: Oct. 30, 2023

Silk nanofibers (SNF) have great applications in high-performance functional nanocomposites due to their excellent mechanical properties, biocompatibility, and degradability. However, the preparation of SNF by traditional methods often requires use some environmentally harmful or toxic reagents, limiting its application green chemistry. In this paper, we successfully prepared using natural silk as raw material solvent stripping technology adjusting concentration solution ratio (the diameter about 120 nm). Using above SNFs materials, membranes were vacuum filtration technology. addition, an SNF/MXene nanocomposite with humidity sensitivity simply coating MXene nanosheets fibers. The conductivity can approach 1400.6 S m−1 strength (51.34 MPa). high conductivity, degradability be potentially applied field electromagnetic interference (EMI) shielding, providing a feasible for development materials.

Language: Английский

Citations

1
Scaffold for the Minimally Invasive Repair of Soft Tissue Inspired by Soggy Shrunk Puffed Food DOI Creative Commons
Yong He

Research Square (Research Square), Journal Year: 2023, Volume and Issue: unknown

Published: Aug. 4, 2023

Abstract Minimally invasive injection of tissue engineering scaffolds has been gaining attention due to featuring several advantages requiring a small incision, entailing simple operation procedure, and involving quick recovery. However, it remains challenge because larger must pass through an extremely thin needle. Herein, inspired by the phenomenon that puffed food becomes soggy shrinks when exposed air, novel scaffold treatment method is proposed; namely, lyophilization & dampening (L&D) treatment, which reduces printed hydrogel volume around 90%. Lyophilization can remove water inside scaffolds; Dampening is, placing freeze-dried into vapor atmosphere, make shrunk suitable size for minimally injection. Moreover, unlike existing air-dried technique feature high mechanical modulus, developed herein low modulus (2.88 kPa), thus minimizing foreign body sensation after implantation. Furthermore, injected rapidly swell their original act as regeneration media. Accordingly, specialized tool namely “BioGun” designed ("BioBullet”). This strategy would potentially overcome technical bottlenecks limiting clinical soft defect repair.

Language: Английский

Citations

0