Molecules,
Journal Year:
2025,
Volume and Issue:
30(4), P. 967 - 967
Published: Feb. 19, 2025
Xanthone
dimers,
a
distinctive
class
of
natural
metabolites
renowned
for
their
unique
structures,
are
abundantly
present
in
diverse
array
angiosperms,
fungi,
and
lichens.
These
compounds
not
only
exhibit
remarkable
diversity
but
also
possess
broad
spectrum
biological
activities.
In
this
comprehensive
review
spanning
from
1966
to
2024,
we
synthesized
the
relevant
literature
delve
into
occurrence,
potency,
molecular
structure
chemical
xanthone
dimers.
The
aim
is
serve
as
an
insightful
reference
point
future
scientific
inquiries
dimers
potential
applications.
Molecular Medicine Reports,
Journal Year:
2024,
Volume and Issue:
30(6)
Published: Oct. 8, 2024
Alzheimer's
disease
(AD)
is
a
neurodegenerative
disorder
that
impairs
learning
and
memory,
with
high
rates
of
mortality.
Birch
bark
has
been
traditionally
used
in
the
treatment
various
skin
ailments.
Betulin
(BT)
key
compound
birch
exhibits
diverse
pharmacological
benefits
therapeutic
potential
AD.
However,
effects
molecular
mechanisms
BT
AD
remain
unclear.
The
present
study
aimed
to
predict
targets
AD,
determine
specific
underlying
through
network
pharmacology
analysis
experimental
validation.
PharmMapper
was
target
genes
BT,
four
databases
were
searched
screen
for
targets.
intersection
identified
using
jveen
website.
Drug‑disease
protein‑protein
interaction
networks
hub
obtained
visualized
Search
Tool
Retrieval
Interacting
Genes/Proteins
database
Cytoscape.
Database
Annotation,
Visualization
Integrated
Discovery
Gene
Ontology
(GO)
Kyoto
Encyclopedia
Genes
Genomes
(KEGG)
enrichment
analyses,
AutoDock
docking
genes.
Subsequently,
network‑predicted
verified
Journal of Biochemical and Molecular Toxicology,
Journal Year:
2024,
Volume and Issue:
38(10)
Published: Sept. 12, 2024
Abstract
One
of
the
main
factors
in
pathophysiology
amyotrophic
lateral
sclerosis
is
oxidative
stress.
Mangiferin
(MF),
a
natural
plant
polyphenol,
has
anti‐inflammatory
and
antioxidant
effects.
The
aim
our
study
was
to
investigate
protective
effects
mechanisms
MF
hSOD1‐G93A
ALS
cell
model.
Our
result
revealed
that
treatment
reduced
generation
reactive
oxygen
species
(ROS)
malondialdehyde
(MDA),
decreased
damage,
apoptosis.
Additionally,
it
observed
significantly
increased
synthesis
genes
hemeoxygenase‐1
NAD(P)H:
quinone
oxidoreductase
1,
which
are
downstream
Nrf2
signaling
pathway,
expression
activation
nuclear
factor
erythroid
2‐related
2
(Nrf2).
knockdown
greatly
promoted
apoptosis,
reversed
by
treatment.
To
summarize,
pathway
scavenged
MDA
ROS
protect
Aging and Health Research,
Journal Year:
2024,
Volume and Issue:
4(2), P. 100194 - 100194
Published: May 29, 2024
Formaldehyde
(FA)
is
a
highly
reactive
molecule
that
considered
as
community
concern
due
to
the
huge
human
exposure
in
industries,
dissection
unit
hospitals
and
academics.
Furthermore,
it
used
manufacturing
paper
plywood,
preservation
of
biological
specimens.
FA
present
normally
certain
concentration
brain
its
metabolism
plays
major
role
methylation
demethylation
DNA,
RNA
histones.
However,
excess
reduces
cognitive
function
causes
dementia
especially
aging
brain.
Recent
studies
investigated
link
between
age-related
impairment
through
NMDA-receptor
dysregulation
other
mechanisms
including
amyloid-β
(Aβ)
accumulation,
alterations
alcohol
dehydrogenase-5
(ALDH5)
Tau
dysmetabolism
aggregation
which
serves
Alzheimer's
disease
(AD).
hypothesis
agreed
when
Aβ
accumulate
extracellular
space,
prevents
medications
are
dissolved
interstitial
fluid
from
permeating
injured
cortical
neurons
leads
death.
Although
treatment
AD
with
phototherapy
has
been
achieved
before
involves
destruction
deposit;
however,
reducing
amount
derivatives
remains
golden
step
prevention.
