Advanced Healthcare Materials,
Journal Year:
2024,
Volume and Issue:
13(27)
Published: July 15, 2024
Abstract
Hydrogel‐based
injectable
drug
delivery
systems
provide
temporally
and
spatially
controlled
release
with
reduced
adverse
effects
on
healthy
tissues.
Therefore,
they
represent
a
promising
therapeutic
option
for
unresectable
solid
tumor
entities.
In
this
study,
peptide‐starPEG/hyaluronic
acid‐based
physical
hydrogel
is
modified
ferrocene
to
programmable
orchestrated
by
matrix‐drug
interaction
local
reactive
oxygen
species
(ROS).
The
ROS‐responsive
(hiROSponse)
exhibits
adequate
biocompatibility
biodegradability,
which
are
important
clinical
applications.
HiROSponse
loaded
the
two
cytostatic
drugs
(hiROSponse
dox/ptx
)
doxorubicin
(dox)
paclitaxel
(ptx).
Dox
hydrophilic
compound
its
mainly
Fickian
diffusion,
while
hydrophobic
interactions
between
ptx
can
control
thus
be
regulated
oxidation
of
more
state
ferrocenium.
syngeneic
malignant
melanoma‐bearing
mouse
model,
hiROSponse
slows
growth
without
causing
side
doubles
relative
survival
probability.
Programmable
further
demonstrated
in
model
low
physiological
ROS
level,
where
dox
release,
dose
irradiation,
resulting
ROS‐triggered
lead
inhibition
increased
survival.
Langmuir,
Journal Year:
2024,
Volume and Issue:
40(23), P. 12226 - 12238
Published: May 30, 2024
We
have
red-shifted
the
light
absorbance
property
of
a
Re(I)-tricarbonyl
complex
via
distant
conjugation
ferrocene
moiety
and
developed
novel
ReFctp,
[Re(Fctp)(CO)3Cl],
where
Fctp
=
4′-ferrocenyl-2,2′:6′,2″-terpyridine.
ReFctp
showed
green
to
red
absorption
ability
blue
emission,
indicating
its
potential
for
photodynamic
therapy
(PDT)
application.
The
introduced
ferrocene-based
transitions,
which
lie
at
higher
wavelength
within
PDT
therapeutic
window.
time-dependent
density
functional
theory
excited
state
calculations
revealed
an
efficient
intersystem
crossing
is
helpful
PDT.
elicited
both
type
I
II
pathways
reactive
oxygen
species
(ROS)
generation
facilitated
NADH
(1,4-dihydro-nicotinamide
adenine
dinucleotide)
oxidation
upon
exposure
visible
light.
Importantly,
effective
penetration
through
layers
clinically
relevant
3D
multicellular
tumor
spheroids
localized
primarily
in
mitochondria
(Pearson's
correlation
coefficient,
PCC
0.65)
A549
cancer
cells.
produced
more
than
20
times
phototoxicity
(IC50
∼1.5
μM)
by
inducing
ROS
altering
mitochondrial
membrane
cells
nonferrocene
analogue
Retp,
[Re(CO)3(tp)Cl],
tp
2,2′:6′,2″-terpyridine.
induced
apoptotic
mode
cell
death
with
notable
photocytotoxicity
index
(PI,
PI
IC50dark/IC50light)
selectivity
(SI,
SI
normal
cell's
IC50dark/cancer
IC50light)
range
25–33.
Biomolecules,
Journal Year:
2025,
Volume and Issue:
15(2), P. 262 - 262
Published: Feb. 11, 2025
This
review
examines
representatives
of
organocyclophosphazenes
that
can
act
against
tumor
cells
the
ovaries,
prostate
gland,
mammary
and
colon,
etc.,
have
antimicrobial
action
mycobacteria
M.
tuberculosis,
Gram-positive
bacteria
B.
cereus,
Gram-negative
K.
pneumaniae,
fungi
genus
Candida,
other
microorganisms.
Cyclomatric
phosphazenes
be
used
as
carriers
physiologically
active
substances
in
field
detection,
well
gels
for
wound
surgery
drug
delivery
platforms.
In
gels,
cyclophosphazenes
are
cross-linking
agents.
Cyclophosphazenes
containing
multiple
bonds
organic
radicals
proposed
to
dentistry
additives
basic
dental
compositions.
Particular
attention
is
paid
cytotoxic
materials
their
advantages
over
commercial
substances.
The
presents
prospects
practical
application
various
functional
groups
(chalcone,
anthraquinone,
pyrrolidine,
morpholine,
ferrocene,
etc.)
pharmaceuticals.
may
interest
researchers
working
organoelement
chemistry,
medicine,
pharmacy.
Pharmaceutics,
Journal Year:
2024,
Volume and Issue:
16(12), P. 1530 - 1530
Published: Nov. 28, 2024
This
perspective
begins
with
an
overview
of
the
major
impact
that
dendron,
dendrimer,
and
dendritic
state
(DDDS)
discovery
has
made
on
traditional
polymer
science.
The
entire
DDDS
technology
is
underpinned
by
unprecedented
new
polymerization
strategy
referred
to
as
step-growth,
amplification-controlled
(SGACP).
SGACP
paradigm
allows
for
routine
common
monomers
organic
materials
into
precise
monodispersed,
macromolecules
(i.e.,
dendrons/dendrimers)
nanoscale
sizes
structure-controlled
features
match
rival
discrete
in
vivo
biopolymers
such
proteins
nucleic
acids
DNA,
siRNA,
mRNA,
etc.).
These
architectures
exhibit
intrinsic
properties
widely
recognized
define
a
fourth
architecture
class,
namely:
Category
(IV):
dendrons,
dendrimers,
random
hyperbranched
polymers
after
categories:
(I)
linear,
(II)
cross-linked,
(III)
simple-branched
types.
Historical
confusion
over
first
examples
structure
confirmed
verified
cascade,
arborol
syntheses,
while
associated
misuse
accepted
terminology
also
reviewed
clarified.
importance
classifying
all
dendrons
dendrimers
based
branch
cell
symmetry
significant
role
critical
nanoscale-design
parameters
(CNDPs)
optimizing
products
pharma/nanomedicine
applications
focus
enhancing
stealth,
non-complement
activation
presented.
followed
extraordinary
growth
observed
amphiphilic
dendron/dendrimer
syntheses
their
self-assembly
supramolecular
assemblies,
well
many
unique
demonstrated
pharma
nanomedicine,
especially
involving
siRNA
delivery
mRNA
vaccine
development.
concluded
optimistic
expectations
predicted
dendron
dendrimer
application
roles
pharma,
life
sciences.
