Insight into the Functional Dynamics and Challenges of Exosomes in Pharmaceutical Innovation and Precision Medicine

Pharmaceutics, Journal Year: 2024, Volume and Issue: 16(6), P. 709 - 709

Published: May 24, 2024

Of all the numerous nanosized extracellular vesicles released by a cell, endosomal-originated exosomes are increasingly recognized as potential therapeutics, owing to their inherent stability, low immunogenicity, and targeted delivery capabilities. This review critically evaluates transformative of exosome-based modalities across pharmaceutical precision medicine landscapes. Because precise biomolecular cargo delivery, posited ideal candidates in drug enhancing regenerative strategies, advancing diagnostic technologies. Despite significant market growth projections exosome therapy, its utilization is encumbered substantial scientific regulatory challenges. These include lack universally accepted protocols for isolation complexities associated with navigating environment, particularly guidelines set forth U.S. Food Drug Administration (FDA). presents comprehensive overview current research trajectories aimed at addressing these impediments discusses prospective advancements that could substantiate clinical translation exosomal therapies. By providing analysis both capabilities hurdles therapeutic applications, this article aims inform direct future paradigms, thereby fostering integration systems into mainstream practice.

Language: Английский

---

The modification of conventional liposomes for targeted antimicrobial delivery to treat infectious diseases

Discover Nano, Journal Year: 2025, Volume and Issue: 20(1)

Published: Jan. 30, 2025

Some of the most crucial turning points in treatment strategies for some major infectious diseases including AIDS, malaria, and TB, have been reached with introduction antimicrobials vaccines. Drug resistance poor effectiveness are key limitations that need to be overcome. Conventional liposomes explored as a delivery system bioactives treat provide an efficient approach maximize therapeutic outcomes, drug stability, targetability, reduce side-effects antimicrobials, enhance vaccine performance where necessary. However, pathological understanding become more known, advanced liposomal technologies was born continue having profound effect on targeted chemotherapy diseases. This review therefore provides concise incursion into recent vogue formulations used An appraisal immunological, stimuli-responsive, biomimetic functionalized other novel modifications conventional is assimilated sync mutations resistant pathogens.

Language: Английский

---

The Optimization Design of Macrophage Membrane Camouflaging Liposomes for Alleviating Ischemic Stroke Injury through Intranasal Delivery

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(5), P. 2927 - 2927

Published: March 2, 2024

Ischemic stroke is associated with a high mortality rate, and effective treatment strategies are currently lacking. In this study, we aimed to develop novel nano delivery system treat ischemic via intranasal administration. A three-factor Box–Behnken experimental design was used optimize the formulation of liposomes co-loaded Panax notoginseng saponins (PNSs) Ginsenoside Rg3 (Rg3) (Lip-Rg3/PNS). Macrophage membranes were coated onto surface optimized target site brain. The double-loaded disguised by macrophage (MM-Lip-Rg3/PNS) spherical, in “shell–core” structure, encapsulation rates 81.41% (PNS) 93.81% (Rg3), showed good stability. vitro, MM-Lip-Rg3/PNS taken up brain endothelial cells clathrin-dependent endocytosis micropinocytosis pathways. Network pharmacology experiments predicted that could regulate multiple signaling pathways reducing apoptosis inflammatory responses. After 14 days MM-Lip-Rg3/PNS, survival weight, neurological score middle cerebral artery occlusion (MCAO) rats significantly improved. hematoxylin eosin (H&E) TUNEL staining results can reduce neuronal cell infiltration protect vivo biological have shown free Rg3, PNS, alleviate inflammation apoptosis, especially indicating biomimetic improve therapeutic effects drugs. Overall, potential targeted for therapy.

Language: Английский

---

Nanomedicines as a cutting-edge solution to combat antimicrobial resistance

RSC Advances, Journal Year: 2024, Volume and Issue: 14(45), P. 33568 - 33586

Published: Jan. 1, 2024

Antimicrobial mechanism of nanomaterials to combat AMR.

Language: Английский

---

Nanocurcumin in myocardial infarction therapy: emerging trends and future directions

Frontiers in Bioengineering and Biotechnology, Journal Year: 2025, Volume and Issue: 12

Published: Jan. 8, 2025

Myocardial infarction (MI) is the leading cause of morbidity and mortality worldwide. Curcumin has been observed to significantly reduce pathological processes associated with MI. Its clinical application limited due its low bioavailability, rapid degradation, poor solubility. Advancements in nanotechnology can be used enhance therapeutic potentials nano-formulation enhances solubility, stability, allowing more precise delivery ischemic cardiac tissue. nanoparticles have successfully infarct size, maintain heart function by modulating essential molecular pathways liposomal formulations provide sustained release higher tissue penetration improved pharmacokinetics enhanced efficacy. Preclinical studies revealed that nanocurcumin drastically lower oxidative stress indicators, inflammatory cytokines, damage. Micelles composed polymers demonstrated high biocompatibility targeting capabilities increased cardio-protective effects. Research trials are for comprehensive analysis efficacy curcumin-based nano-therapeutics cardiovascular condition lowering risk

Language: Английский

---

Green and sustainable separation processes for environmental and chemical engineering

Elsevier eBooks, Journal Year: 2025, Volume and Issue: unknown, P. 457 - 479

Published: Jan. 1, 2025

Language: Английский

---

Integrating engineered nanomaterials with extracellular vesicles: advancing targeted drug delivery and biomedical applications

Frontiers in Nanotechnology, Journal Year: 2025, Volume and Issue: 6

Published: Jan. 22, 2025

Extracellular vesicles (EVs), natural membrane-bound structures released by cells, offer a promising platform for precise and targeted delivery of therapeutic payloads, including drugs nanoparticles. This comprehensive review explores the integration engineered nanomaterials with EVs to advance drug systems. It covers various aspects this integration, techniques synthesizing, loading, characterizing, applying within EVs. Methodologies integrating diverse nanocarriers like nanoparticles, liposomes, quantum dots into are discussed, along characterization methods such as electron microscopy light scattering. Attention is also given considerations biological compatibility, safety assessments, strategies surface modification enhance targeting precision. Highlighting applications, delivery, cancer therapy, vaccine development, underscores potential EV-nanomaterial hybrids leverage EVs’ innate capabilities versatility nanomaterials. However, it addresses challenges scalability, standardization, that must be overcome facilitate clinical translation these biomedical solutions.

Language: Английский

---

Challenges and Future Prospects in the Development of Biomimetic Materials for Tissue Engineering and Regenerative Medicine

˜The œminerals, metals & materials series, Journal Year: 2025, Volume and Issue: unknown, P. 683 - 692

Published: Jan. 1, 2025

Language: Английский

---

Global trends and research hotspots in nanodrug delivery systems for breast cancer therapy: a bibliometric analysis (2013–2023)

Discover Oncology, Journal Year: 2025, Volume and Issue: 16(1)

Published: March 6, 2025

Nanomedicine offers fresh approaches for breast cancer treatment, countering traditional limitations. The nanodrug delivery system's precision and biocompatibility hold promise, yet integration hurdles remain. This study reviews nano systems in therapy from 2013 to 2023, guiding future research directions. In this study, we conducted a comprehensive search on Web of Science database (Guilin Medical University purchase edition) downloaded literature related the field published between 2023. We analyzed these publications using R software, VOSviewer, CiteSpace software. reviewed 2632 documents, showing steady publication increase peaking at 408 2022. China, USA, India, Iran were prominent publishing. Chinese Academy Sciences Tabriz key collaboration centers. Notably, Journal Controlled Release Biomaterials ranked among top 10 journals citations, establishing their representation. Key terms like "breast cancer," "nanoparticles," "drug delivery," "in-vitro," "delivery" widely used. Research focused optimizing drug targeting, utilizing tumor microenvironment delivery, improving efficiency. system, as an innovative approach, numerous advantages has garnered global attention researchers. provides analysis status hotspots within realm therapy, offering valuable insights domain.

Language: Английский

---

Advancing Eco-friendly Biomedicine: Sustainable Nanocomposites as Platforms for Genetic Vaccines

Published: Jan. 1, 2025

Language: Английский

---