Immune imbalance in Lupus Nephritis: The intersection of T-Cell and ferroptosis DOI Creative Commons

Yunhe Fan,

Kuai Ma,

Yumeng Lin

et al.

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: Dec. 12, 2024

Ferroptosis is a novel form of cell death characterized by unlimited accumulation iron-dependent lipid peroxides. It often accompanied disease, and the relationship between ferroptosis immune cells regulation has been attracting increasing attention. Initially, it was found in cancer research that inhibition regulatory T (Treg) promotion CD8+ jointly promoted formation an immune-tolerant environment tumors. T-cell subsequently to have immunoregulatory effects other diseases. As autoimmune disease imbalance, attracted attention for its potential regulating balance lupus nephritis. This article reviews metabolic processes within different subsets nephritis (LN), including follicular helper (TFH) cells, (Th)17 Th1 Th2 Treg reveals these cellular metabolisms not only facilitate imbalance but are also closely associated with occurrence ferroptosis. Consequently, we hypothesize targeting pathways could become direction effectively treating altering differentiation incidence

Language: Английский

Iron homeostasis and ferroptosis in human diseases: mechanisms and therapeutic prospects DOI Creative Commons

Qin Ru,

Yusheng Li,

Lin Chen

et al.

Signal Transduction and Targeted Therapy, Journal Year: 2024, Volume and Issue: 9(1)

Published: Oct. 14, 2024

Iron, an essential mineral in the body, is involved numerous physiological processes, making maintenance of iron homeostasis crucial for overall health. Both overload and deficiency can cause various disorders human diseases. Ferroptosis, a form cell death dependent on iron, characterized by extensive peroxidation lipids. Unlike other kinds classical unprogrammed death, ferroptosis primarily linked to disruptions metabolism, lipid peroxidation, antioxidant system imbalance. Ferroptosis regulated through transcription, translation, post-translational modifications, which affect cellular sensitivity ferroptosis. Over past decade or so, diseases have been as part their etiology, including cancers, metabolic disorders, autoimmune diseases, central nervous cardiovascular musculoskeletal Ferroptosis-related proteins become attractive targets many major that are currently incurable, some regulators shown therapeutic effects clinical trials although further validation potential needed. Therefore, in-depth analysis its molecular mechanisms may offer additional strategies prevention treatment. In this review, we discuss significance contribution etiology development along with evidence supporting targeting approach. Importantly, evaluate recent promising interventions, providing guidance future targeted treatment therapies against

Language: Английский

Citations

50
Iron metabolism in rheumatic diseases DOI Creative Commons

Aliakbar Givian,

Amin Azizan,

Ahmadreza Jamshidi

et al.

Journal of Translational Autoimmunity, Journal Year: 2025, Volume and Issue: 10, P. 100267 - 100267

Published: Jan. 5, 2025

Iron is a crucial element for living organism in terms of oxygen transport, hematopoiesis, enzymatic activity, mitochondrial respiratory chain function and also immune system function. The human being has evolved mechanism to regulate body iron. In some rheumatic diseases such as rheumatoid arthritis (RA), systemic lupus erythematous (SLE), sclerosis (SSc), ankylosing spondylitis (AS), gout, this balanced iron regulation impaired. Altered homeostasis can contribute disease progression through ROS production, fibrosis, inflammation, abnormal bone homeostasis, NETosis cell senescence. review, we have focused on the metabolism its role progression.

Language: Английский

Citations

0
Exploring the Potential of Mitochondria‐Targeted Drug Delivery for Enhanced Breast Cancer Therapy DOI Creative Commons
Yalda Ghazizadeh, Seyedeh Elnaz Sharifi-Ardani, Negin Tajik

et al.

International Journal of Breast Cancer, Journal Year: 2025, Volume and Issue: 2025(1)

Published: Jan. 1, 2025

Breast cancer stands as the utmost prevalent malignancy in women, impacting epithelial tissue of breast and often displaying resistance to effective treatment due its diverse molecular histological features. Current modalities may exhibit decreasing efficacy over time can lead disease progression. The mitochondria, a crucial organelle responsible for cellular metabolism energy supply, stand highly sensitive both heat reactive oxygen species, presenting an assuring target photodynamic photothermal therapies (PTTs) cure. employment nanodrug carriers combination deliveries holds promise addressing challenges related drug degradation off-target toxicity. By circumventing reticuloendothelial system, nanocarriers bolster drug's bioavailability at intended site ensure controlled codelivery multiple drugs, thereby maintaining normal pharmacokinetic features regular pharmacodynamic characteristics different therapeutic mechanisms. precision this innovative technology have revolutionized delivery, substantially enhancing effectiveness. In pursuit targeting mitochondrial modifications cells, various such therapy (PDT), PTT, chemodynamic (CDT) been explored. These improved efficiency mitochondria-targeted their advantageous properties minimal toxicity, noninvasiveness, reduced resistance, safer profile. Our review article provides exhaustive overview alterations environment BC, impact on BC development, potential targets treatment, nanotherapeutic approaches limitations these approaches.

Language: Английский

Citations

0
FSP1 regulates ferroptosis and mitochondrial function during mouse oocyte maturation DOI

Hongzhen Ruan,

Huifen Xiang, Yajing Liu

et al.

Experimental Cell Research, Journal Year: 2025, Volume and Issue: unknown, P. 114524 - 114524

Published: March 1, 2025

Language: Английский

Citations

0
Identification of key regulatory factors for m6A in myasthenia gravis and characteristics of the immune characteristics DOI Creative Commons

Yaoqi Wu,

Xiaoqing Cai,

Yingying Jiao

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 20, 2024

Abstract Myasthenia gravis (MG), a rare autoimmune disorder, presents complex pathogenesis involving various immune molecules. The modification of N6-methyladenosine (m6A) regulates diverse metabolic and immunopathological processes; however, its role in MG remains unclear. We downloaded dataset GSE85452 from the GEO database to identify differentially expressed genes regulated by m6A. Random Forest (RF) method was utilized pivotal regulatory associated with m6A modification. Subsequently, prognostic model crafted confirmed using this gene set. Patients were stratified according expression levels these key genes. Additionally, MG-specific signatures delineated examining cell infiltration patterns their correlations. Further functional annotation, protein-protein interaction mapping, molecular docking analyses performed on biomarkers, leading discovery three that exhibited significant differential within dataset: RBM15, CBLL1, YTHDF1.The random forest algorithm as MG, validated constructing clinical prediction model. Based expression, we divided patients into two groups, revealing distinct varying abundances. also discovered 61 phenotype conducted an in-depth exploration biological roles. YTHDF1 found positively correlated CD56dim natural killer cells, T type 1 helper cells. These stable diagnostic m6A-related markers both validation cohorts. Our findings suggest for MG. analysis may elucidate roles microenvironment

Language: Английский

Citations

0
Immune imbalance in Lupus Nephritis: The intersection of T-Cell and ferroptosis DOI Creative Commons

Yunhe Fan,

Kuai Ma,

Yumeng Lin

et al.

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: Dec. 12, 2024

Ferroptosis is a novel form of cell death characterized by unlimited accumulation iron-dependent lipid peroxides. It often accompanied disease, and the relationship between ferroptosis immune cells regulation has been attracting increasing attention. Initially, it was found in cancer research that inhibition regulatory T (Treg) promotion CD8+ jointly promoted formation an immune-tolerant environment tumors. T-cell subsequently to have immunoregulatory effects other diseases. As autoimmune disease imbalance, attracted attention for its potential regulating balance lupus nephritis. This article reviews metabolic processes within different subsets nephritis (LN), including follicular helper (TFH) cells, (Th)17 Th1 Th2 Treg reveals these cellular metabolisms not only facilitate imbalance but are also closely associated with occurrence ferroptosis. Consequently, we hypothesize targeting pathways could become direction effectively treating altering differentiation incidence

Language: Английский

Citations

0