Expert Review of Neurotherapeutics, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 20
Published: Dec. 20, 2024
Post-traumatic stress disorder (PTSD) can have debilitating effects on quality of life, and conventional treatments show mixed results. Neuromodulation is emerging as a promising approach for treating PTSD. This review examines current neuromodulatory PTSD, highlights methodologies, clinical outcomes, gaps in the literature to help guide future research.
Language: Английский
Frontiers in Surgery, Journal Year: 2025, Volume and Issue: 12
Published: April 1, 2025
Transcranial low-intensity focused ultrasound (FUS) enables noninvasive, targeted, and reversible blood-brain barrier (BBB) disruption, facilitating drug delivery liquid biopsy of the brain. Using fluorescein sodium (FNa) with macroscopic widefield fluorescence microscopic confocal laser endomicroscopy (CLE) imaging, we assessed BBB permeability after applying a frameless, electromagnetic-guided FUS system in porcine model confirmed established MRI protocol conventional histology. Both FNa imaging findings correlated contrast-enhanced MRI, providing direct evidence disruption. This approach demonstrates utility for evaluating preclinical studies.
Language: Английский
Citations
0
Investigative Radiology, Journal Year: 2024, Volume and Issue: unknown
Published: Aug. 20, 2024
Invasive open surgery used to be compulsory access tumor mass perform excision or resection. Development of minimally invasive laparoscopic procedures followed, as well catheter-based approaches, such stenting, endovascular surgery, chemoembolization, brachytherapy, which minimize side effects and reduce the risks patients. Completely noninvasive bring further benefits in terms reducing risk, procedure time, recovery potential infection, other effects. Focusing ultrasound waves from outside body specifically at disease site has proven a safe approach localized ablative hyperthermia, mechanical ablation, targeted drug delivery. Focused medical intervention was proposed decades ago, but it only became feasible plan, guide, monitor, control treatment with advanced radiological imaging capabilities. The purpose this review is describe capabilities approaches these tasks, emphasis on magnetic resonance ultrasound. Some already are clinical practice, more trial stage. Imaging fully integrated workflow includes following: (1) planning, definition target regions adjacent organs risk; (2) real-time monitoring via thermometry imaging, cavitation feedback, motion control, assure targeting safety normal tissues; (3) evaluation efficacy, assessment ablation physiological parameters, blood supply. This also focuses sonosensitive microparticles nanoparticles, microbubbles injected bloodstream. They enable energy deposition down microvascular level, induce vascular inflammation shutdown, accelerate clot dissolution, delivery interventions, including focal gene Especially exciting ability opening blood-brain barrier desired areas within brain. Overall, focused under image guidance rapidly developing, become choice interventional radiology tool treat cure
Language: Английский
Citations
2
Additive manufacturing, Journal Year: 2024, Volume and Issue: unknown, P. 104465 - 104465
Published: Oct. 1, 2024
Language: Английский
Citations
0
Expert Review of Neurotherapeutics, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 20
Published: Dec. 20, 2024
Post-traumatic stress disorder (PTSD) can have debilitating effects on quality of life, and conventional treatments show mixed results. Neuromodulation is emerging as a promising approach for treating PTSD. This review examines current neuromodulatory PTSD, highlights methodologies, clinical outcomes, gaps in the literature to help guide future research.
Language: Английский
Citations
0