An Updated Review on the Nanocarriers Based Co‐Delivery System of Chemo Drug Doxorubicin and Phytocompounds DOI Open Access
Pratibha Pandey, Meenakshi Verma, Sorabh Lakhanpal

et al.

Polymers for Advanced Technologies, Journal Year: 2024, Volume and Issue: 36(1)

Published: Dec. 26, 2024

ABSTRACT Numerous issues and concerns are associated with current cancer therapeutics, such as multidrug resistance tumors, drug toxicity, severe side effects, financial burden. Phytocompounds from plants have garnered significant interest alternatives adjunct therapies to mitigate these effects owing their safety, efficacy, cost‐effectiveness. As demonstrated by a number of preclinical clinical investigations, phytocompounds combinations doxorubicin mediate anticancer modulating multiple signaling pathways linked immune system mobilization, apoptosis promotion, inhibition excessive cellular proliferation. However, continue encounter challenges related inadequate bioavailability, pharmacokinetics, metabolism. To address challenges, the utilization different types nanoparticles has become in nanomedicine for targeted delivery, enhancing retention time, reducing toxicity. This field study showcases remarkable amalgamation nanotechnology chemo‐drugs (doxorubicin). Thus, this review focuses on recent developments nanocarriers based delivery systems, particularly those intended simultaneous chemotherapy medicines, synthesizing existing knowledge filling research gaps. also discussed combined therapy chemotherapeutic drugs other nanotechnology‐based carriers treatment.

Language: Английский

Recent Advancements in Gallic Acid-Based Drug Delivery: Applications, Clinical Trials, and Future Directions DOI Creative Commons
Ranjit K. Harwansh, Rohitas Deshmukh,

V Shukla

et al.

Pharmaceutics, Journal Year: 2024, Volume and Issue: 16(9), P. 1202 - 1202

Published: Sept. 13, 2024

Gallic acid (GA) is a well-known herbal bioactive compound found in many herbs and foods like tea, wine, cashew nuts, hazelnuts, walnuts, plums, grapes, mangoes, blackberries, blueberries, strawberries. GA has been reported for several pharmacological activities, such as antioxidant, inflammatory, antineoplastic, antimicrobial, etc. Apart from its incredible therapeutic benefits, it associated with low permeability bioavailability issues, limiting their efficacy. belongs to BCS (Biopharmaceutics classification system) class III (high solubility probability). In this context, novel drug delivery approaches played vital role resolving these issues. Nanocarrier systems help improve moiety’s physical chemical stability by encapsulating them into lipidic or polymeric matrix core system. regard, researchers have developed wide range of nanocarrier GA, including liposomes, transfersomes, niosomes, dendrimers, phytosomes, micelles, nanoemulsions, metallic nanoparticles, solid lipid nanoparticles (SLNs), nanostructured carriers, polymer conjugates, the present review, different search engines Scopus, PubMed, ScienceDirect, Google Scholar referred acquiring recent information on theme work. Therefore, review paper aims emphasize systems, patents, clinical updates GA.

Language: Английский

Citations

6
Exploring the landscape of Lipid Nanoparticles (LNPs): A comprehensive review of LNPs types and biological sources of lipids DOI Creative Commons

Alanood S Alfutaimani,

N Alharbi,

Amirah Alahmari

et al.

International Journal of Pharmaceutics X, Journal Year: 2024, Volume and Issue: 8, P. 100305 - 100305

Published: Nov. 18, 2024

Language: Английский

Citations

6
Recent advances in lipid-based nanocarriers for advanced skin cancer therapy DOI

Mohd Shoab Ali,

Mohammad Ali Abdullah Almoyad, Shadma Wahab

et al.

International Journal of Pharmaceutics, Journal Year: 2025, Volume and Issue: unknown, P. 125203 - 125203

Published: Jan. 1, 2025

Language: Английский

Citations

0
Optimization of Chitosan-Coated Niosomes Encapsulating Doxycycline Hyclate for pH-Responsive Drug Release DOI Creative Commons
Carmen Maria Meoli, Domenico Riccardi, Lucia Baldino

et al.

Industrial & Engineering Chemistry Research, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 6, 2025

Language: Английский

Citations

0
Nanoparticle-Based Delivery Systems for Phytochemicals in Cancer Therapy: Molecular Mechanisms, Clinical Evidence, and Emerging Trends DOI
Mahmoud A.H. Mostafa, Hani M. J. Khojah

Drug Development and Industrial Pharmacy, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 31

Published: March 21, 2025

This review examines recent advancements in nanoparticle-based delivery systems for phytochemicals, focusing on their role overcoming multidrug resistance, improving therapeutic efficacy, and facilitating clinical translation. highlights advances nanoparticle-enabled phytochemical to enhance bioavailability, improve outcomes, enable targeted applications. By comparing various nanoparticle systems, formulation methods, efficacy data, it identifies gaps current research guides the development of more effective, next-generation phytochemical-loaded nanocarriers. A systematic literature published between 2000 2024 was conducted using PubMed, Scopus, Web Science. Articles cancer therapy were included. Compounds such as curcumin, resveratrol, quercetin, epigallocatechin gallate demonstrate enhanced anti-cancer when encapsulated nanoparticles, leading improved increased tumor cell targeting, reduced toxicity. Clinical trials indicate regression fewer adverse effects. Emerging approaches-such nanogels, hybrid combination therapies with immune checkpoint inhibitors-further refine treatment efficacy. Nanoparticle-based significantly potential making them promising candidates safer, effective treatments. However, challenges related regulatory guidelines, scalability, long-term safety must be addressed fully realize potential.

Language: Английский

Citations

0
Lipid-based Nanoparticles: Strategy for Targeted Cancer Therapy DOI Creative Commons
Ashish Singh Chauhan, Pallavi Chand, Tarun Parashar

et al.

BIO Integration, Journal Year: 2025, Volume and Issue: 6(1)

Published: Jan. 1, 2025

Lipid-based Nanoparticles (LBNPs) have emerged as a transformative approach in cancer treatment, offering innovative drug delivery solutions that enhance therapeutic efficacy while minimizing adverse effects. By exploring the characterization, classification, synthesis, targeting strategies, and advantages of LBNPs, this study highlights how LBNPs been used to overcome limitations traditional chemotherapy improve patient outcomes. As nanotechnology revolutionizes therapy, emergence promising strategy for targeted has led optimism regarding future treatment. This review extensively assesses structure, categories, production methods, benefits, recent advancements treating cancer. It also current challenges possible directions. is aimed at providing comprehensive understanding LBNPs’ potential therapy. Liposomes, nanostructured lipid carriers, solid nanoparticles, lipid-polymer hybrid nanoparticles are all types each with unique features interest These particles can be synthesized through various procedures, such bulk nanoprecipitation, solvent-based emulsification, or microfluidics. Passive systems, active responsive platforms direct tumors. Consequently, provide an improved release pattern minimizes side effects enhancing efficacy. With combination offer hopeful Continued research expected outcomes overall quality life care.

Language: Английский

Citations

0
Lipid nanoparticles for treatment of glioblastoma multiforme: current status of research and clinical translation DOI Creative Commons
Mugdha Kulkarni, Karthik Nadendla, Ananth Pai

et al.

Journal of Drug Delivery Science and Technology, Journal Year: 2025, Volume and Issue: unknown, P. 106891 - 106891

Published: April 1, 2025

Language: Английский

Citations

0
Chitosan-encapsulated lipid-based nanovesicles for therapeutic applications and tissue engineering: A Review DOI Creative Commons

Pegah Vosoughi,

Seyed Morteza Naghib,

Taha Jafari

et al.

Carbohydrate Polymer Technologies and Applications, Journal Year: 2025, Volume and Issue: unknown, P. 100805 - 100805

Published: April 1, 2025

Language: Английский

Citations

0
Sustainable Nanomedicine: Enhancement of Asplatin’s Cytotoxicity In Vitro and In Vivo Using Green-Synthesized Zinc Oxide Nanoparticles Formed via Microwave-Assisted and Gambogic Acid-Mediated Processes DOI Creative Commons
Hatem A. F. M. Hassan, Nada K. Sedky, Mohamed S. Nafie

et al.

Molecules, Journal Year: 2024, Volume and Issue: 29(22), P. 5327 - 5327

Published: Nov. 12, 2024

Chemoresistance encountered using conventional chemotherapy demands novel treatment approaches. Asplatin (Asp), a platinum (IV) prodrug designed to release cisplatin and aspirin in reductive environment, has demonstrated high cytotoxicity at reduced drug resistance. Herein, we investigated the ability of green-synthesized nanocarriers enhance Asp’s efficacy. Zinc oxide nanoparticles (ZnO-NPs) were synthesized green microwave-assisted method with reducing capping agent gambogic acid (GA). These then loaded Asp, yielding Asp@ZnO-NPs. Transmission electron microscopy was utilized study morphological features ZnO-NPs. Cell viability studies conducted on MDA-MB-231 breast cancer cells Asp@ZnO-NPs significantly decrease half-maximal inhibitory concentration (IC50) (5 ± 1 µg/mL). This further flow cytometric analysis that revealed capacity increase late apoptotic fractions. Furthermore, vivo carried out solid Ehrlich carcinoma-bearing mice showed significant tumor volume reduction (156.3 7.6 mm3), compared Asp alone (202.3 8.4 mm3) untreated controls (342.6 10.3 mm3). The histopathological increased necrosis Asp@ZnO-NPs-treated group. Asp@ZnO-NPs, an eco-friendly approach, enhanced anticancer activity, offering sustainable solution for potent formulations.

Language: Английский

Citations

1
An Updated Review on the Nanocarriers Based Co‐Delivery System of Chemo Drug Doxorubicin and Phytocompounds DOI Open Access
Pratibha Pandey, Meenakshi Verma, Sorabh Lakhanpal

et al.

Polymers for Advanced Technologies, Journal Year: 2024, Volume and Issue: 36(1)

Published: Dec. 26, 2024

ABSTRACT Numerous issues and concerns are associated with current cancer therapeutics, such as multidrug resistance tumors, drug toxicity, severe side effects, financial burden. Phytocompounds from plants have garnered significant interest alternatives adjunct therapies to mitigate these effects owing their safety, efficacy, cost‐effectiveness. As demonstrated by a number of preclinical clinical investigations, phytocompounds combinations doxorubicin mediate anticancer modulating multiple signaling pathways linked immune system mobilization, apoptosis promotion, inhibition excessive cellular proliferation. However, continue encounter challenges related inadequate bioavailability, pharmacokinetics, metabolism. To address challenges, the utilization different types nanoparticles has become in nanomedicine for targeted delivery, enhancing retention time, reducing toxicity. This field study showcases remarkable amalgamation nanotechnology chemo‐drugs (doxorubicin). Thus, this review focuses on recent developments nanocarriers based delivery systems, particularly those intended simultaneous chemotherapy medicines, synthesizing existing knowledge filling research gaps. also discussed combined therapy chemotherapeutic drugs other nanotechnology‐based carriers treatment.

Language: Английский

Citations

1