Journal of Pharmaceutical Innovation, Journal Year: 2025, Volume and Issue: 20(2)
Published: March 6, 2025
Language: Английский
Journal of Pharmaceutical Innovation, Journal Year: 2025, Volume and Issue: 20(2)
Published: March 6, 2025
Language: Английский
Journal of Pharmaceutical Analysis, Journal Year: 2025, Volume and Issue: unknown, P. 101248 - 101248
Published: Feb. 1, 2025
Language: Английский
Citations
0International Journal of Pharmaceutics, Journal Year: 2025, Volume and Issue: 673, P. 125415 - 125415
Published: Feb. 27, 2025
Language: Английский
Citations
0Journal of Medicinal Chemistry, Journal Year: 2025, Volume and Issue: unknown
Published: March 4, 2025
Mas-related G protein-coupled receptor X2 (MrgX2) plays a key role in pseudoallergy reactions; thus, it is of great significance to screen compounds with antipseudoallergy activity via MrgX2. Cell membrane chromatography (CMC) demonstrates potential drug screening, but requires further optimization improve its specificity and stability. In this study, new CMC system incorporating His-tag-oriented immobilized proteins was constructed MrgX2 antagonists. Single His-tag-fused extracted intactly covalently bond divinyl sulfone-modified amino silica gel obtain bioaffinity composites. The characterized composites were utilized establish MrgX2-His-tag@VS/CMC Compound Z-3578 screened from compound library 3010 revealed efficient vitro vivo conclusion, the oriented-immobilized will provide an analytical tool for screening active precursors.
Language: Английский
Citations
0Trends in Food Science & Technology, Journal Year: 2025, Volume and Issue: unknown, P. 104961 - 104961
Published: March 1, 2025
Language: Английский
Citations
0Journal of Pharmaceutical Innovation, Journal Year: 2025, Volume and Issue: 20(2)
Published: March 6, 2025
Language: Английский
Citations
0