Challenges in Humoral Immune Response to Adeno-Associated Viruses Determination DOI Open Access
Daria A. Naumova,

Tatyana Krokunova,

Denis Maksimov

et al.

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(2), P. 816 - 816

Published: Jan. 19, 2025

Adeno-associated viruses (AAVs) are non-pathogenic, replication-deficient that have gained widespread attention for their application as gene therapy vectors. While these vectors offer high transduction efficiency and long-term expression, the host immune response poses a significant challenge to clinical success. This review focuses on obstacles evaluating humoral AAVs. We discuss problems with validation of in vitro tests possible approaches overcome them. Using published data neutralizing titers AAV serotypes, we built first antigenic maps AAVs order visualize relationships between varying serotypes.

Language: Английский

Challenges in Humoral Immune Response to Adeno-Associated Viruses Determination DOI Open Access
Daria A. Naumova,

Tatyana Krokunova,

Denis Maksimov

et al.

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(2), P. 816 - 816

Published: Jan. 19, 2025

Adeno-associated viruses (AAVs) are non-pathogenic, replication-deficient that have gained widespread attention for their application as gene therapy vectors. While these vectors offer high transduction efficiency and long-term expression, the host immune response poses a significant challenge to clinical success. This review focuses on obstacles evaluating humoral AAVs. We discuss problems with validation of in vitro tests possible approaches overcome them. Using published data neutralizing titers AAV serotypes, we built first antigenic maps AAVs order visualize relationships between varying serotypes.

Language: Английский

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