Molecules, Journal Year: 2025, Volume and Issue: 30(3), P. 692 - 692
Published: Feb. 4, 2025
Phosphodiesterase 4 (PDE4) catalyzes cyclic adenosine monophosphate (cAMP) hydrolysis, playing a crucial role in the cAMP signaling pathway. is secondary messenger involved numerous physiological functions, such as inflammatory responses, immune neural activity, learning, and memory. PDE4 inhibition important for controlling anti-inflammatory neuroprotective effects. In this review, we provide comprehensive overview of molecular functions properties human PDE4s. The study presents detailed sequence information isoforms structural catalytic domain members family. We also review inhibitory effects inhibitors roflumilast cilomilast related to respiratory diseases PDE4. crystal structures complex with are analyzed. This provides useful future design novel inhibitors.
Language: Английский