Comprehensive Aerodynamic and Physicochemical Stability Evaluations of Nanocrystal-Based Dry Powder Inhalers: The Role of Mannitol and Leucine in Enhancing Performance DOI Creative Commons
Heba Banat, Attila Nagy, Árpád Farkas

et al.

Pharmaceutics, Journal Year: 2025, Volume and Issue: 17(4), P. 436 - 436

Published: March 28, 2025

Background: Nanocrystals, a carrier-free nanotechnology, offer significant advantages for pulmonary drug delivery by enhancing the dissolution and solubility of poorly soluble drugs while maintaining favorable biological properties low toxicity. This study aims to investigate aerodynamic performance stability nanocrystal-based dry powders (NC-DPs). Methods: Nanocrystalline suspensions were produced via wet media milling subjected studies before undergoing nano spray drying. A factorial design was employed optimize process parameters. The influence mannitol leucine, individually in combination, evaluated terms (Aerodynamic Particle Sizer (APS), silico modeling) physicochemical at room temperature (in desiccator) accelerated conditions (40 ± 2 °C, 75 5% relative humidity). Results: APS analysis revealed that leucine-containing (K-NC-Ls) exhibited smallest median (1.357 µm) geometric mean (1.335 particle sizes, dispersibility. However, results indicated highest exhaled fraction K-NC-L, highlighting need optimized excipient selection. Although showed lowest fraction, it mainly deposited extra-thoracic region silico. mannitol/leucine combination (K-NC-ML) high lung deposition Also, K-NC-ML demonstrated superior stability, with 6% reduction D[0.5] decrease span overtime. Furthermore, no changes crystallinity, thermal behavior, release, or mass diameter observed under stress conditions. Conclusions: These findings confirm combined incorporation leucine NC-DP formulations enhances performance, making promising approach delivery.

Language: Английский

Comprehensive Aerodynamic and Physicochemical Stability Evaluations of Nanocrystal-Based Dry Powder Inhalers: The Role of Mannitol and Leucine in Enhancing Performance DOI Creative Commons
Heba Banat, Attila Nagy, Árpád Farkas

et al.

Pharmaceutics, Journal Year: 2025, Volume and Issue: 17(4), P. 436 - 436

Published: March 28, 2025

Background: Nanocrystals, a carrier-free nanotechnology, offer significant advantages for pulmonary drug delivery by enhancing the dissolution and solubility of poorly soluble drugs while maintaining favorable biological properties low toxicity. This study aims to investigate aerodynamic performance stability nanocrystal-based dry powders (NC-DPs). Methods: Nanocrystalline suspensions were produced via wet media milling subjected studies before undergoing nano spray drying. A factorial design was employed optimize process parameters. The influence mannitol leucine, individually in combination, evaluated terms (Aerodynamic Particle Sizer (APS), silico modeling) physicochemical at room temperature (in desiccator) accelerated conditions (40 ± 2 °C, 75 5% relative humidity). Results: APS analysis revealed that leucine-containing (K-NC-Ls) exhibited smallest median (1.357 µm) geometric mean (1.335 particle sizes, dispersibility. However, results indicated highest exhaled fraction K-NC-L, highlighting need optimized excipient selection. Although showed lowest fraction, it mainly deposited extra-thoracic region silico. mannitol/leucine combination (K-NC-ML) high lung deposition Also, K-NC-ML demonstrated superior stability, with 6% reduction D[0.5] decrease span overtime. Furthermore, no changes crystallinity, thermal behavior, release, or mass diameter observed under stress conditions. Conclusions: These findings confirm combined incorporation leucine NC-DP formulations enhances performance, making promising approach delivery.

Language: Английский

Citations

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