Hydrogels as Suitable miRNA Delivery Systems: A Review

Polymers, Journal Year: 2025, Volume and Issue: 17(7), P. 915 - 915

Published: March 28, 2025

The use of miRNA in therapeutics has, since its discovery 1993, attracted tremendous attention, and research this area has progressed rapidly. Since the advent RNA interference (RNAi), much about nucleic acid siRNA been elucidated. At same time, no miRNA-based drugs have passed phase II clinical trials. A significant obstacle to drug development is ease degradation relatively short half-life vivo miRNA. Hydrogels are networks cross-linked polymer chains with ability 'swell'. They shown remarkable capabilities that improve properties other researched carriers. In combination modification strategies inorganic carriers, hydrogel systems show promise for sustained delivery novel drugs. Although reported recently, focus predominantly on their wound-healing properties, a dearth information carrier abilities. This paper focuses more latest advancements developing hydrogels as system, emphasizing review will cover methods fabrication, efforts release, biomedical applications, future prospects.

Language: Английский

Nanostructured Lipid Carrier-Filled Hydrogel Beads for the Delivery of Curcumin: Digestion, Intestinal Permeation, and Antioxidant Bioactivity After Gastrointestinal Digestion

Pharmaceutics, Journal Year: 2025, Volume and Issue: 17(5), P. 541 - 541

Published: April 22, 2025

Background/Objectives: The aim of the present study was to develop nanostructured lipid carrier (NLC)-filled hydrogel beads for delivery curcumin in functional foods. Methods: Curcumin-loaded NLC-filled based on calcium alginate were developed using extrusion method. Various preparation parameters, physicochemical characteristics, gastrointestinal fates, and antioxidant bioactivities studied confirm feasibility this system. Results: NLCs successfully filled into with an encapsulation efficiency above 80%. stability test displayed that encapsulated within further enhanced when beads. During vitro digestion, lipolysis rate matrix release adjusted by ex vivo intestinal permeation indicated from digestion products curcumin-loaded NLC-hydrogel beads, prepared appropriate concentrations (0.5% 1%), significantly compared NLCs. Furthermore, (1% alginate) exhibited bioactivity those Conclusions: This demonstrated might be a promising system hydrophobic bioactive compounds food systems.

Language: Английский