Deciphering the Dilemma: Anticoagulation for Heart Failure With Preserved Ejection Fraction (HFpEF)

Cureus, Journal Year: 2023, Volume and Issue: unknown

Published: Aug. 10, 2023

Impairment in ventricular relaxation and preserved left ejection fraction are the two main features of heart failure with (HFpEF) a difficult clinical condition. Therapeutic choices for HFpEF patients still scarce despite its rising frequency negative effects on morbidity mortality, necessitating creative methods to enhance results. The increased thromboembolic risk seen these individuals raises questions about relevance anticoagulation therapy HFpEF. Although has been shown be beneficial decreased (HFrEF) other high-risk cardiovascular disorders, efficacy safety present challenging therapeutic challenge. Anticoagulants have subject trials HFpEF, but results conflicting, giving clinicians only little information which make decisions. decision-making process is made more by worries potential bleeding hazards, particularly susceptible elderly comorbidities. link between anticoagulant medication thoroughly analyzed this narrative review. In cardiac fibrosis endothelial dysfunction create prothrombotic milieu, as highlighted passage. Also covered recent developments innovative biomarker research cutting-edge imaging techniques, may provide ways spot who might benefit from anticoagulation. This conundrum resolved using precision medicine strategies based classification individualized choices. review emphasizes need establish best use within framework personalized shared decision-making. To successfully manage reduce consequences patients, it essential perform well-designed studies advance our understanding pathophysiology These ultimately improve prognosis quality life people suffer mysterious ailment.

Language: Английский

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Implementing CYP2C19-guided clopidogrel therapy: a scoping review of pharmacogenomic testing services

The Pharmacogenomics Journal, Journal Year: 2025, Volume and Issue: 25(3)

Published: April 25, 2025

Abstract Pharmacogenomic testing for CYP2C19 helps personalise clopidogrel therapy and reduces the risk of experiencing a secondary myocardial infarction in individuals with impaired function. Routine testing, however, is uncommon it proposed that key requirements processes services are poorly understood. This scoping review aimed to explore literature identify their commonalities inform design delivery future services. In total, 37 eligible studies describing across hospital community settings were retrieved. Key elements included multi-disciplinary approach involving physicians pharmacists, provision pre-implementation training education, electronic communication test results. Result integration into clinical decision support systems improved practical application pharmacogenomic testing. The identification may be used by institutions looking deliver guide therapy.

Language: Английский

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The Critical Role of Pharmacists in the Clinical Delivery of Pharmacogenetics in the U.S

Pharmacy, Journal Year: 2023, Volume and Issue: 11(5), P. 144 - 144

Published: Sept. 10, 2023

Since the rebirth of pharmacogenomics (PGx) in 1990s and 2000s, with new discoveries genetic variation underlying adverse drug response analytical technologies such as sequencing microarrays, there has been much interest clinical application PGx testing. The early involvement pharmacists studies establishment organizations to support dissemination information about variants have naturally resulted leaders implementation. This paper presents an overview evolving role pharmacists, discusses potential challenges future paths, primarily focused U.S. Pharmacists positioned themselves testing, will prepare next generation utilize testing their scope practice.

Language: Английский

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The Potential Roles of Pharmacists in the Clinical Implementation of Pharmacogenomics

Pharmacy, Journal Year: 2023, Volume and Issue: 11(6), P. 180 - 180

Published: Nov. 19, 2023

The field of pharmacogenomics is at the forefront a healthcare revolution, promising to usher in new era precision medicine [...].

Language: Английский

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