Challenges and considerations in liposomal hydrogels for the treatment of infection
Expert Opinion on Drug Delivery,
Journal Year:
2025,
Volume and Issue:
unknown, P. 1 - 22
Published: Jan. 10, 2025
Liposomal
hydrogels
are
novel
drug
delivery
systems
that
comprise
preformed
liposomes
incorporated
in
destined
for
mostly
localized
therapy,
herewith
antimicrobial
therapy.
The
formulation
benefits
from
versatility
of
as
lipid-based
nanocarriers
enable
various
antimicrobials
different
lipophilicities,
and
secondary
vehicle,
hydrogel,
assures
better
retention
time
at
the
infection
site.
Especially
an
era
alarming
resistance,
efficient
therapy
avoids
systemic
exposure
related
side
effects
is
crucial.
We
provide
overview
liposomal
were
developed
superior
infections
sites,
with
focus
on
skin
vaginal
infections.
review
summarizes
challenges
site
most
common
infection-causing
pathogens
offers
commentary
relevant
features
needs
to
optimize
increase
outcome.
discuss
impact
composition,
size,
choice
polymer-forming
hydrogel
outcome
based
literature
own
experience
field.
offer
improved
By
fine-tuning
well
properties,
formulations
performance
can
be
optimized
targeting
specific
Language: Английский
Substantial Effects of Carotenoids on Skin Health: A Mechanistic Perspective
Ressin Varghese,
No information about this author
Arnold Emerson,
No information about this author
Brigitte Vannier
No information about this author
et al.
Phytotherapy Research,
Journal Year:
2025,
Volume and Issue:
unknown
Published: March 30, 2025
ABSTRACT
There
has
been
an
upsurge
in
the
incidences
of
skin
disorders
and
their
mortalities
owing
to
various
environmental,
hormonal,
epigenetic
risk
factors.
Melanoma,
atopic
dermatitis,
psoriasis,
photoaging
associated
consequences
are
largely
observed
population
globally.
The
social
stigma,
economic
burden,
adverse
effects
from
chronic
medication
endured
by
patients
emphasize
necessity
more
effective
natural
therapeutics.
Carotenoids
economically
valuable
tetraterpenoid
pigments
synthesized
plants
microorganisms,
which
play
a
paramount
role
overall
growth
development.
Extensive
vitro
vivo
investigations
evidenced
that
phytopigments
like
carotenoids
target
multiple
intracellular
signaling
pathways
involving
mitogen‐activated
protein
kinases,
Janus
kinase/signal
transducers,
activators
transcription,
apoptotic,
autophagy
proteins
ameliorate
melanoma.
Besides,
curbed
activation
release
immunoregulatory
molecules
such
as
cytokines
chemokines
abrogate
immune
disorders,
photoaging,
consequences.
Here,
we
provide
holistic
discussion
on
pathophysiology
prominent
ameliorating
,
clinical
interventions.
We
also
advocate
requisite
formulating
carotenoid
medications
after
extensive
interventions
validation
for
mitigating
dysfunctions.
Language: Английский
Advancements in Early Diagnosis and Personalized Treatment Strategies for Skin Diseases: A Meta-Analysis of Interdisciplinary Approaches Combining Dermatology, Genetics, and Immunology
Research Square (Research Square),
Journal Year:
2025,
Volume and Issue:
unknown
Published: April 15, 2025
Abstract
Several
Skin
illnesses,
including
dermatological
disorders
psoriasis,
eczema,
and
skin
cancers,
remain
serious
issues
to
the
health
of
humankind.
Advances
in
diagnostic
technology,
treatment
practices,
cross-disciplinary
studies
recent
past
have
potential
revolutionize
management
these
diseases.
This
meta-analysis
is
aimed
explore
novel
developments
early
diagnosis
personalized
regimens
with
a
focus
on
integration
dermatology
genetics,
immunology,
other
clinical
sciences.
We
will
address
emerging
techniques,
such
as
AI-based
imaging,
biomarkers,
how
they
impact
identification
care
disease
its
earliest
form.
Besides,
we
examine
latest
medicine
treatments,
biologics
targeted
therapies,
which
been
promising
improve
outcomes
patients.
There
need
for
interdisciplinary
cooperation
between
genetics
order
maximize
protocols
advance
knowledge
biology.
review
also
assess
preventative
strategies,
genetic
testing,
lifestyle
modifications,
treatment,
mitigate
progression
chronic
disorders.
By
collating
data
across
disciplines,
this
research
yield
an
integrative
summary
practice
future
ultimately
enhance
quality
life
individuals
further
boundaries
science.
review,
way
that
global
initiatives
can
increase
access
new
therapies
ensure
technological
advancements
dermatologic
become
available
diverse
groups
people
be
discussed.
Bridging
gaps
healthcare
infrastructure,
especially
low-resource
environments,
vital
move
towards
alleviating
burden
disease.
Language: Английский
Explainable AI in Healthcare Imaging for Medical Diagnosis
Vandana Babbar,
No information about this author
Chetna Kaushal
No information about this author
Advances in computational intelligence and robotics book series,
Journal Year:
2025,
Volume and Issue:
unknown, P. 107 - 120
Published: March 7, 2025
The
most
cutting-edge
machine
learning
and
deep
techniques
in
the
healthcare
industry
are
presented
by
Digital
Revolution
of
AI,
with
an
emphasis
on
explainable
artificial
intelligence
(XAI).
This
chapter
examines
how
XAI
may
advance
medical
field
to
increase
end
users'
confidence.
It
covers
new
ideas
uses
XAI,
making
it
a
intellectual
resource
for
scholars
practitioners
interested
this
developing
provides
comprehensive
explanation
AI
precision
medicine,
including
all
aspects.
importance
Explainable
(XAI)
is
main
topic
discussion.
Also
offers
real-world
case
studies
examples
offer
useful
insights
into
use
medicine.
Language: Английский
Collagen as a biomaterial for skin wound healing: From structural characteristics to the production of devices for tissue engineering
The International Journal of Artificial Organs,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Feb. 2, 2025
Collagen
is
an
abundant
component
in
the
human
body
and
plays
a
fundamental
role
integrity
function
of
various
tissues,
including
skin,
bones,
joints,
connective
tissues.
This
natural
polymer
also
contributes
to
physiological
balance
individual
health.
Within
this
context,
article
reviews
structure
collagen,
describing
intrinsic
characteristics
that
range
from
its
molecular
composition
organization
into
bundles.
Additionally,
review
highlights
some
applications
collagen
tissue
engineering,
particularly
mimicry
skin’s
extracellular
matrix.
For
review,
searches
were
performed
PubMed,
Scopus,
Web
Sciences.
The
inclusion
criteria
established
based
on
relevance
studies
for
objectives
methodological
quality.
After
selection
articles,
critical
analysis
their
content
was
conducted
information
synthesized
presented
concisely.
Analysis
properties
revealed
key
importance
design
bioactive
materials
regenerative
applications.
However,
challenges
such
as
need
improvement
integration
implanted
better
understanding
underlying
biological
processes
remain.
Language: Английский