Journal of Food Science and Technology, Journal Year: 2024, Volume and Issue: unknown
Published: Dec. 7, 2024
Language: Английский
Nutrients, Journal Year: 2024, Volume and Issue: 16(12), P. 1813 - 1813
Published: June 8, 2024
Background: Ashwagandha has been reported to reduce stress and attenuate cognitive decline associated with inflammation neurodegeneration in clinical populations. However, the effects as a potential nootropic nutrient younger populations are unclear. This study examined of liposomal ashwagandha supplementation on function, mood, markers health safety healthy young men women. Methods: 59 women (22.7 ± 7 yrs., 74.9 16 kg, 26.2 5 BMI) fasted for 12 h, donated fasting blood sample, were administered COMPASS function test battery (Word Recall, Word recognition, Choice Reaction Time Task, Picture Recognition, Digit Vigilance Corsi Block test, Stroop test) profile mood states (POMS). In randomized double-blind manner, participants 225 mg placebo (Gum Arabic) or (Withania somnifera) root leaf extract coated covering. After 60-min, repeated assessments. Participants continued (225 mg/d) 30 days then returned lab repeat experiment. Data analyzed using general linear model (GLM) univariate analysis measures pairwise comparisons mean changes from baseline 95% confidence intervals (CI). Results: improved acute and/or 30-day Recall (correct recalled attempts), (targets identified), Recognition (“yes” correct responses, overall reaction time), Color-Word (congruent words identified, POMS (tension fatigue) more consistently several differences observed between groups. Conclusion: Results support contentions that mg) may improve some memory, attention, vigilance, executive while decreasing perceptions tension fatigue individuals. Retrospectively registered trial ISRCTN58680760.
Language: Английский
Citations
10
Biochemical and Biophysical Research Communications, Journal Year: 2025, Volume and Issue: unknown, P. 151383 - 151383
Published: Jan. 1, 2025
Language: Английский
Citations
0
Current Pharmacology Reports, Journal Year: 2025, Volume and Issue: 11(1)
Published: Feb. 7, 2025
Language: Английский
Citations
0
Pharmaceuticals, Journal Year: 2025, Volume and Issue: 18(2), P. 261 - 261
Published: Feb. 15, 2025
Long-lasting brain fatigue is a consequence of stroke or traumatic injury associated with emotional, psychological, and physical overload, distress in hypertension, atherosclerosis, viral infection, aging-related chronic low-grade inflammatory disorders. The pathogenesis linked to disrupted neurotransmission, the glutamate-glutamine cycle imbalance, glucose metabolism, ATP energy supply, which are multiple molecular targets signaling pathways neuroendocrine-immune blood circulation systems. Regeneration damaged tissue long-lasting multistage process, including spontaneously regulating hypothalamus-pituitary (HPA) axis-controlled anabolic-catabolic homeostasis recover harmonized sympathoadrenal system (SAS)-mediated function, deregulated gene expression rehabilitation. driving mechanism spontaneous recovery regeneration cross-talk mediators neuronal, microglia, immunocompetent, endothelial cells collectively involved neurogenesis angiogenesis, plant adaptogens can target. Adaptogens small molecules origin that increase adaptability organisms stress by interaction HPA axis SAS (neuroendocrine-immune cardiovascular complex), targeting adaptive GPCR pathways. Two major groups comprise (i) phenolic phenethyl phenylpropanoid derivatives (ii) tetracyclic pentacyclic glycosides, whose chemical structure be distinguished as related correspondingly monoamine neurotransmitters (epinephrine, norepinephrine, dopamine) steroid hormones (cortisol, testosterone, estradiol). In this narrative review, we discuss multitarget integrated pharmacological activity botanical ischemic stroke, fatigue; time-dependent dual response physiological regulatory systems support overload; (iii) dose-dependent reversal (hormetic) effect adaptogens. This review shows adaptogenic concept cannot reduced rectified various effects on selected specific modes action without estimating their interactions within networks complex that, turn, regulates other (cardiovascular, gastrointestinal, reproductive systems) due numerous intra- extracellular communications feedback regulations. These result polyvalent pleiotropic adaptogens, essential for characterizing distinct types botanicals. They trigger defense leads extension limits resilience inducing mental For first time, justifies potential particularly hybrid preparation (BHP) Arctic Root Ashwagandha, providing rationale use individuals experiencing fatigue. provided insight into future research network pharmacology preventing rehabilitating following trauma, infections.
Language: Английский
Citations
0
South African Journal of Botany, Journal Year: 2025, Volume and Issue: 181, P. 315 - 338
Published: April 25, 2025
Language: Английский
Citations
0
International Journal of Food Science, Journal Year: 2025, Volume and Issue: 2025(1)
Published: Jan. 1, 2025
As awareness of the link between diet and health grows, people are increasingly prioritizing functional foods that offer additional benefits beyond basic nutrition. Ashwagandha, scientifically known as Withania somnifera (WS) , is a perennial plant which belongs to family Solanaceae, grows abundantly in subtropical regions world. Ashwagandha renowned Ayurvedic herb with diverse applications global dietary supplements traditional medicines. It has extensive medicinal potential Indian systems such (Ayurvedic, Unani, Siddha) contemporary medicine, recognized “Indian ginseng.” WS additive composed various phytochemicals active compounds withanolides, polyphenols, flavonoids, alkaloids, exhibit therapeutic properties, including anti‐inflammatory, anticancer, antistress, antioxidant, antimicrobial, antidiabetic, cardioprotective, hypoglycemic, hepatoprotective, immunomodulatory, rejuvenating effects. been proven be highly effective against numerous neurological psychological disorders. The incorporation ashwagandha into food enhances biological activity well making it valuable benefits. This review provides an updated analysis emphasizing its bioactive compounds, extraction techniques, applications. Unlike previous studies primarily focused on this highlights integration systems, addressing technological challenges, stability, commercial viability. Additionally, compiles advancements analytical offering insights enhancing bioavailability sensory optimization, thereby bridging herbal use modern science.
Language: Английский
Citations
0
Physiologia Plantarum, Journal Year: 2024, Volume and Issue: 176(5)
Published: Sept. 1, 2024
Abstract Pathogenesis‐related proteins (PR), including osmotins, play a vital role in plant defense, being activated response to diverse biotic and abiotic stresses. Despite their significance, the mechanistic insights into of osmotins defense have not been extensively explored. The present study explores cloning characterization osmotin gene ( WsOsm ) from Withania somnifera , aiming illuminate its mechanisms. Quantitative real‐time PCR analysis revealed significant induction various phytohormones e.g. abscisic acid, salicylic methyl jasmonate, brassinosteroids, ethrel, as well stresses like heat, cold, salt, drought. To further elucidate 's functional role, we overexpressed Nicotiana tabacum resulting heightened resistance against Alternaria solani pathogen. Additionally, observed enhancements shoot length, root biomass transgenic tobacco plants compared wild plants. Notably, WsOsm‐ overexpressing seedlings demonstrated improved salt drought stress tolerance, particularly at seedling stage. Confocal histological H 2 O biochemical studies antioxidant enzyme activities higher levels lines, indicating enhanced defense. Furthermore, pull‐down assay mass spectrometry potential interaction between defensin, known antifungal PR protein (WsDF). This suggests novel mediating responses by interacting with other proteins. Overall, these findings pave way for future applications developing stress‐tolerant crops improving strategies pathogens.
Language: Английский
Citations
3
Journal of Clinical Medicine, Journal Year: 2024, Volume and Issue: 13(14), P. 4088 - 4088
Published: July 12, 2024
Background and Objectives: Fibromyalgia is a multifaceted frequently misunderstood chronic pain disease marked by widespread musculoskeletal cognitive/somatic dysfunction. This trial aims to contribute the existing knowledge on treating fibromyalgia (FM) with medical cannabis (Cannabis sativa L.) explore safer more effective administration method. The goal provide evidence-based findings that can guide alternative treatment options for FM patients assessing pilot study. Materials Methods: was performed at therapy unit of San Carlo Hospital (Potenza, Italy) administrating 30 100 mg/day Bedrocan® (Bedrocan International, Veendam, Netherlands) as decoction. Numerical Rating Scale (NRS) SF-12 short-form health questionnaire were used evaluate intensity quality life beginning study 6th-month follow-up. A systematic review all clinical studies investigating use reduce also undertaken place this in context evidence base. Results: Pain evaluated NRS lowered from median 8 [95% CI 7.66–8.54] baseline 4 (95% 3.28–4.79) after 6 months follow-up (p-value < 0.001; t-test). Similarly, significant physical mental state improvement, questionnaire, found 96.67% 82.33% patients, respectively 44.11–51.13 state, 53.48–58.69 assessed follow-up; p-value analysis literature identified 10 trials concerning cannabis. Conclusions: Considering results present review, it possible assume may be considered an who do not respond conventional pharmacological therapy.
Language: Английский
Citations
1
International Journal of Basic & Clinical Pharmacology, Journal Year: 2024, Volume and Issue: 13(4), P. 475 - 485
Published: June 25, 2024
Background: KaraCalm™ is a novel polyherbal formulation obtained from the combination of Valeriana officinalis extract, Passiflora incarnata Ocimum sanctum Ziziphus jujuba Rosmarinus and Nigella sativa extract. The objective present investigation was to assess efficacy safety manage stress improve sleep in healthy subjects randomized, double-blind, placebo-controlled clinical study. Methods: A total 60 volunteers were randomized into two groups, with 30 group placebo group. Participants asked take 500 mg or once daily for 56 days. As primary outcomes, analysis performed by using Actiwatch, while level evaluated Perceived Stress Scale (PSS) scores baseline end study period. Serum cortisol, hs-CRP period assessed as secondary endpoints. Results: An increase overall quality observed compared measured time, onset latency, wake after minutes, number awakenings. There also reduction PSS study, indicating reduced levels. significant cortisol hs-C-reactive protein (CRP) levels further supported effectiveness reducing stress. no change analyses patients intervention when start end. Conclusions: can be considered safe effective dietary herbal Supplement reduce quality.
Language: Английский
Citations
0
IntechOpen eBooks, Journal Year: 2024, Volume and Issue: unknown
Published: Aug. 30, 2024
Alzheimer’s disease (AD) is an age-related neurodegenerative disorder characterized by memory deficits. It associated with the presence of intracellular neurofibrillary tangles (NFTs) and extracellular amyloid beta plaques, loss neuronal subpopulations, cholinergic fibers, microglial inactivation. According to studies, from year 2000–2020, death toll attributed AD increased 146.2%, its major causes are neurodegeneration oxidative stress (OS). Currently, available treatment options limited, there no cure for disease. In Asia, such as in China India, herbal medicines have been used diseases thousands years, which has recently attracted considerable attention due development curative drugs AD. this chapter, we first summarized pathogenic factors secondly, that extensively investigated both models clinical trials. Also, specified potential targets herbs view signaling pathways implicated inflammatory pathogenesis. We consider knowledge can be favorable disease-modifying
Language: Английский
Citations
0