Canola Oil Ameliorates Obesity by Suppressing Lipogenesis and Reprogramming the Gut Microbiota in Mice via the AMPK Pathway

Nutrients, Journal Year: 2024, Volume and Issue: 16(19), P. 3379 - 3379

Published: Oct. 4, 2024

Background: obesity is a worldwide problem that seriously endangers human health. Canola oil (Col) has been reported to regulate hepatic steatosis by influencing oxidative stress and lipid metabolism in Kunming mice. However, whether Col exhibits an anti-obesity effect altering the gut microbiota remains unknown. Methods: this study, we observed high-fat diet increased lipogenesis disorder C57BL/6J male mice, while administration of suppressed improved disorder. Results: results show markedly reduced final body weight subcutaneous adipose tissue mice fed (HFD) after 6 weeks administration. although did not effectively increase serum concentration HDL, found treatment with notably inhibited low-density lipoprotein (LDL), total cholesterol (TC), triglycerides (TGs) HFD Furthermore, ameliorated liver compared were only diet. We also significantly relative expression sterol regulatory element binding protein (SREBP1/2), peroxisome proliferator-activated receptor γ (PPARγ), insulin-induced genes (Insig1/2) proved be closely associated In addition, acetic acid was Col-treatment Further, noted contributed reprogramming intestinal microbiota. The abundances Akkermansia, Dubosiella, Alistipes enhanced under imply elevated phosphorylation level AMP-activated kinase (AMPK) pathway Conclusions: our study ameliorates suppresses underlying mechanisms are possibly microbiota, particular, acid-mediated via AMPK signaling pathway.

Language: Английский

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Advancing Nutraceuticals in a Promising Frontier in Modern Healthcare

Food and Humanity, Journal Year: 2024, Volume and Issue: unknown, P. 100462 - 100462

Published: Nov. 1, 2024

Language: Английский

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Chemical Composition and Nutritional Value of Flowers and Fruits of Cytisus striatus (Hill) Rothm

Plants, Journal Year: 2024, Volume and Issue: 13(15), P. 2121 - 2121

Published: July 31, 2024

In ancient times, the shoots of certain species within Cytisus genus were used as animal feed. striatus is a plentiful and widespread shrub that has long been utilized soil fertilizer in Iberian Peninsula. The flowers this have traditionally employed for medicinal purposes. However, nutritional value yellow broom fruits remains largely unexplored. study, fruit C. (Cytisus striatus) collected from natural shrubs at three different locations Portugal during same year. An analytical assessment their macro micronutrient content was conducted. Regarding composition, exhibited fibre 18% 42%, protein 21% 12%, lipid 2% 1%, carbohydrate 43% 14%, ash 4% 3%, respectively. Potassium most abundant mineral, with concentrations approximately 20,094 mg/kg 11,746 fruits, followed by calcium, phosphorus, magnesium. Compared to some edible these plant parts showed values similar such lavender, lupins, cowpea pod husks.

Language: Английский

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Therapeutic Potential of Bio-Based Baked Confectionaries

Published: Jan. 1, 2024

Language: Английский

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